Effect of Variations in Fat and Linoleic Acid Intake on the Calcium, Magnesium and Iron Balance of Young Men

1983 ◽  
Vol 27 (5) ◽  
pp. 361-369 ◽  
Author(s):  
Wim van Dokkum ◽  
Frances A. Cloughley ◽  
Karin F.A.M. Hulshof ◽  
Luc A.M. Oosterveen
Keyword(s):  
Linoleic Acid ◽  
Young Men ◽  
Acid Intake ◽  
Linoleic Acid Intake ◽  
Calcium Magnesium

Linoleic acid and breast cancer risk: a meta-analysis

2015 ◽  
Vol 19 (8) ◽  
pp. 1457-1463 ◽  
Author(s):  
Yunping Zhou ◽  
Tao Wang ◽  
Shenyong Zhai ◽  
Wei Li ◽  
Qiang Meng
Keyword(s):  
Breast Cancer ◽  
Linoleic Acid ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Random Effect ◽  
Case Control Studies ◽  
Acid Intake ◽  
Linoleic Acid Intake ◽  
Study Heterogeneity

AbstractObjectivePrior studies on linoleic acid, the predominant n-6 fatty acid, and breast cancer risk have generated inconsistent results. We performed a meta-analysis to summarize the evidence regarding the relationship of dietary and serum linoleic acid with breast cancer risk.DesignPertinent studies were identified by a search of PubMed and EMBASE. The fixed- or random-effect pooled measure was selected based on between-study heterogeneity.ResultsEight prospective cohort studies and four prospective nested case–control studies, involving 10 410 breast cancer events from 358 955 adult females across different countries, were included in present study. Compared with the lowest level of linoleic acid, the pooled relative risk (RR; 95 % CI) of breast cancer was 0·98 (0·93, 1·04) for the highest level of linoleic acid. The pooled RR (95 % CI) for dietary and serum linoleic acid were 0·99 (0·92, 1·06) and 0·98 (0·88, 1·08), respectively. The RR (95 % CI) of breast cancer was 0·97 (0·91, 1·04), 0·95 (0·85, 1·07), 0·96 (0·86, 1·07), 0·98 (0·87, 1·10) and 0·99 (0·85, 1·14) for linoleic acid intake of 5, 10, 15, 20 and 25 g/d, respectively. The risk of breast cancer decreased by 1 % (RR=0·99; 95 % CI 0·93, 1·05) for every 10 g/d increment in linoleic acid intake.ConclusionsThis meta-analysis indicated that both dietary linoleic acid intake and serum linoleic acid level were associated with decreased risk of breast cancer, although none of the associations were statistically significant. Further investigations are warranted.

scholarly journals Associations Between Linoleic Acid Intake and Incident Type 2 Diabetes Among U.S. Men and Women

Diabetes Care ◽  
2019 ◽  
Vol 42 (8) ◽  
pp. 1406-1413 ◽  
Author(s):  
Geng Zong ◽  
Gang Liu ◽  
Walter C. Willett ◽  
Anne J. Wanders ◽  
Marjan Alssema ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Linoleic Acid ◽  
Men And Women ◽  
Incident Type ◽  
Acid Intake ◽  
Linoleic Acid Intake ◽  
Incident Type 2 Diabetes

scholarly journals Linoleic acid intake, plasma cholesterol and 10-year incidence of CHD in 20 000 middle-aged men and women in the Netherlands

2011 ◽  
Vol 107 (7) ◽  
pp. 1070-1076 ◽  
Author(s):  
Janette de Goede ◽  
Johanna M. Geleijnse ◽  
Jolanda M. A. Boer ◽  
Daan Kromhout ◽  
W. M. Monique Verschuren
Keyword(s):  
Linoleic Acid ◽  
The Netherlands ◽  
Plasma Cholesterol ◽  
Hdl Cholesterol ◽  
Carbohydrate Intake ◽  
Men And Women ◽  
Mortality And Morbidity ◽  
Acid Intake ◽  
Hazard Ratios ◽  
Linoleic Acid Intake

We studied the associations of a difference in linoleic acid or carbohydrate intake with plasma cholesterol levels and risk of CHD in a prospective cohort study in the Netherlands. Data on diet (FFQ) and plasma total and HDL-cholesterol were available at baseline (1993–7) of 20 069 men and women, aged 20–65 years, who were initially free of CVD. Incidence of CHD was assessed through linkage with mortality and morbidity registers. During an average of 10 years of follow-up, 280 CHD events occurred. The intake of linoleic acid ranged from 3·6 to 8·0 % of energy (en%), whereas carbohydrate intake ranged from 47·6 to 42·5 en% across quintiles of linoleic acid intake. Linoleic acid intake was inversely associated with total cholesterol and HDL-cholesterol in women but not in men. Linoleic acid intake was not associated with the ratio of total to HDL-cholesterol. No association was observed between linoleic acid intake and CHD incidence, with hazard ratios varying between 0·83 and 1·00 (all P>0·05) compared to the bottom quintile. We conclude that a 4–5 en% difference in linoleic acid or carbohydrate intake did not translate into either a different ratio of total to HDL-cholesterol or a different CHD incidence.

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