Serial Changes in Serum Levels of Pancreatic Isoamylase, Trypsin and Elastase 1 after Surgical Interventions to the Pancreas

1993 ◽  
Vol 10 (5) ◽  
pp. 240-244
Author(s):  
Kazuhiro Iwase ◽  
Tetsuto Takao ◽  
Hirotoshi Watanabe ◽  
Yasuhiro Tanaka ◽  
Tetsuo Kido ◽  
...  
Keyword(s):  
Serum Levels ◽  
Surgical Interventions ◽  
Elastase 1 ◽  
Pancreatic Isoamylase

Elastase-1 vs trypsin, lipase and amylase serum levels in pancreatic diseases

1987 ◽  
Vol 2 (5-6) ◽  
pp. 361-370 ◽  
Author(s):  
Luigi Benini ◽  
Paolo Rizzotti ◽  
Bruna Vaona ◽  
Carlo Sembenini ◽  
Giorgio Brocco ◽  
...  
Keyword(s):  
Serum Levels ◽  
Pancreatic Diseases ◽  
Elastase 1

scholarly journals Effect of Anesthesia/Surgery on Gut Microbiota and Fecal Metabolites and Their Relationship With Cognitive Dysfunction

2021 ◽  
Vol 15 ◽  
Author(s):  
Xinrong Lian ◽  
Qianmei Zhu ◽  
Li Sun ◽  
Yaozhong Cheng
Keyword(s):  
Gut Microbiota ◽  
Cognitive Dysfunction ◽  
Kynurenic Acid ◽  
Serum Levels ◽  
Inflammatory Factors ◽  
Morris Water Maze Test ◽  
Liquid Chromatography Mass Spectrometry ◽  
Surgical Interventions ◽  
The Central Nervous System ◽  
Cognitive Disturbance

Aims: Post-operative cognitive dysfunction (POCD) is the decline in cognitive function of the central nervous system (CNS) after anesthesia/surgery. The present study explored whether anesthesia/surgery altered gut microbiota and fecal metabolites, examining their associations with risk factors of cognitive dysfunction in aged mice.Methods: Sixteen-month-old C57BL/6 mice underwent abdominal surgery under isoflurane anesthesia to establish an animal model of POCD. The Morris water maze test (MWMT) was used as an indicator of memory after surgery. The effects of anesthesia/surgical interventions on gut microbiota, fecal metabolites, hippocampus, and serum levels of inflammatory factors were examined.Results: The anesthesia/surgery induced more serious POCD behavior, increasing brain interleukin (IL)-6, and IL-1β levels than sham control mice. The relative abundance of bacterial genera Bacteroidales_unclassified, Mucispirillum, and Clostridiales_unclassified declined, whereas that of Escherichia–Shigella, actinomyces, Ruminococcus_gnavus_group, and Lachnospiraceae_FCS020_group were enriched after anesthesia/surgery compared to the baseline controls. Liquid chromatography–mass spectrometry (LC–MS) showed that the metabolites differed between post-anesthesia+surgery (post_A + S) and baseline samples and were associated with the fecal metabolism of tryptophan, kynurenic acid, N-oleoyl γ-aminobutyric acid (GABA), 2-indolecarboxylic acid, and glutamic acid. Furthermore, the differential metabolites were associated with alterations in the abundance of specific bacteria. These results indicate that the POCD intervention may be achieved by targeting specific bacteria associated with neurotransmitter metabolism.Conclusions: A transient cognitive disturbance induced by anesthesia/surgery may be associated with unfavorable alterations in gut microbiota and fecal metabolites, thereby contributing to the POCD development.

scholarly journals The effect of serum D-dimer levels on the cognitive outcome of patients with moderate traumatic brain injury

2021 ◽  
Vol 36 (1) ◽  
Author(s):  
Mohammed F.A Ali ◽  
Ahmed M.F Ghoul ◽  
Mohamed I Refaat
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Statistical Significance ◽  
Elevated Serum ◽  
Serum Levels ◽  
Cognitive Outcome ◽  
Treatment Protocols ◽  
Surgical Interventions ◽  
Moderate Traumatic Brain Injury ◽  
D Dimer

Abstract Background Cognitive impairment after traumatic brain injury (TBI) is a main source of morbidity for affected individuals, their family members, and their community. There are numerous serum biomarkers, which are elevated after TBI; one of these is D-dimer. Several studies have related that trauma-related coagulopathy, marked by elevated D-dimer levels, is associated with poor prognosis. Objective The aim of this study was to find if there is a correlation between elevated serum levels of D-dimer and impairment of final cognitive outcome in case suffering of Moderate TBI. Patients and method This is a prospective cohort study with a random sample of 87 patients suffering from moderate TBI. Serum level of D-dimer was requested for all cases after confirming the diagnosis of moderate TBI with post-traumatic GCS 9–12. Head trauma treatment protocols were followed according to each case diagnosis and then at the time of discharge cognitive outcome was assessed for all cases. Neurocognition was assessed by Montreal cognitive assessment-Basic (MoCA-B). Results Eighty-seven cases were included in this trial with a mean age 28 years. 48.3% of cases were treated conservatively while the remaining 51.7% needed surgical interventions for different pathologies. Seventy-five cases had elevated levels of serum D-dimer (86.2%) whereas only 12 cases have within normal levels (13.8%). A twofold increase in the serum D-dimer level was found in 41% of cases, while 34.5% of cases had three- to sixfold increases, and 10% of cases had more than sixfold increase. The mean MoCA-B score was 24 points (range 13–27). Correlating the D-dimer levels statistically with the MoCA scores, age, admission and discharge GCS, and durations of hospital stay did not show any statistical significance with any of these variables. Conclusion The role played by D-dimer in the pathophysiology of cognitive deficits and its correlation with post moderate TBI cognitive outcome was not proven.

Nucleolar Segregation and Chronic Methanol Intoxication

1969 ◽  
Vol 27 ◽  
pp. 360-361
Author(s):  
Julio H. Garcia ◽  
Janice P. Van Zandt
Keyword(s):  
Body Weight ◽  
Methyl Alcohol ◽  
Rhesus Monkeys ◽  
Repeated Administration ◽  
Serum Levels ◽  
Methanol Intoxication ◽  
Intragastric Tube ◽  
Nucleolar Segregation

Repeated administration of methyl alcohol to Rhesus monkeys (Maccaca mulata) by intragastric tube resulted in ultrastructural abnormalities of hepatocytes, which persisted in one animal twelve weeks after discontinuation of the methyl alcohol regime. With dosages ranging between 3.0 to 6.0 gms. of methanol per kg. of body weight, the serum levels attained within a few hours averaged approximately 475 mg. per cent.

Assessment of pancreatic exocrine function in preterms by measurement of fecal elastase 1

2001 ◽  
Vol 120 (5) ◽  
pp. A214-A214
Author(s):  
M VENTRUCCI ◽  
V PAOLETTI ◽  
L CORVAGLIA ◽  
M CAPRETTI ◽  
M MIDDONNO ◽  
...  
Keyword(s):  
Pancreatic Exocrine Function ◽  
Exocrine Function ◽  
Fecal Elastase ◽  
Elastase 1 ◽  
Pancreatic Exocrine

Serum levels of E2 and hCG rise at a faster rate in pregnancies arising from the replacement of fresh rather than frozen embryos

1998 ◽  
Vol 5 (1) ◽  
pp. 142A-142A
Author(s):  
S SPANDORFER ◽  
A KOWALIK ◽  
H LIU ◽  
G SCHATTMAN ◽  
L VEECK ◽  
...  
Keyword(s):  
Serum Levels ◽  
Frozen Embryos
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