Are Collagenous Colitis and Lymphocytic Colitis Distinct Syndromes?

1995 ◽  
Vol 13 (5) ◽  
pp. 301-311 ◽  
Author(s):  
Kay Jackson
Keyword(s):  
Collagenous Colitis ◽  
Lymphocytic Colitis

Sa1017 A COMPARISON OF LYMPHOCYTIC COLITIS AND COLLAGENOUS COLITIS

2020 ◽  
Vol 158 (6) ◽  
pp. S-243-S-244
Author(s):  
Syed Bilal Pasha ◽  
Samantha Dyroff ◽  
Tao Zhang ◽  
Henok Woldu ◽  
Deepthi S. Rao ◽  
...  
Keyword(s):  
Collagenous Colitis ◽  
Lymphocytic Colitis

scholarly journals Familial Microscopic Colitis

2001 ◽  
Vol 15 (5) ◽  
pp. 341-343 ◽  
Author(s):  
Ayman Assad Abdo ◽  
Peter Jeffrey Zetler ◽  
Lawrence S Halparin
Keyword(s):  
Chronic Diarrhea ◽  
Present Report ◽  
Disease Process ◽  
Collagenous Colitis ◽  
Microscopic Colitis ◽  
Familial Occurrence ◽  
Lymphocytic Colitis ◽  
The Third ◽  
Inflammatory Conditions ◽  
Colonic Biopsy

Collagenous and lymphocytic colitis are two inflammatory conditions of the colon that are often collectively referred to as microscopic colitis. The present report describes what is believed to be the third published case of familial microscopic colitis. A 55-year-old woman who suffered from chronic diarrhea was diagnosed with lymphocytic colitis on colonic biopsy. Subsequently, her 36-year-old daughter was diagnosed with collagenous colitis. The familial occurrence of these diseases may support an immunological hypothesis for their etiology. In addition, it supports the assumption that collagenous and lymphocytic colitis are two manifestations of the same disease process rather than two completely separate entities. The familial tendency of this disease may make a case for early colonoscopy and biopsy in relatives of patients diagnosed with microscopic colitis if they present with suggestive symptoms.

scholarly journals Prevalence of Celiac Disease in Collagenous and Lymphocytic Colitis

2000 ◽  
Vol 14 (11) ◽  
pp. 919-921 ◽  
Author(s):  
Helen Rachel Gillett ◽  
Hugh James Freeman
Keyword(s):  
Celiac Disease ◽  
Small Bowel ◽  
Tissue Transglutaminase ◽  
Immunoglobulin A ◽  
Collagenous Colitis ◽  
Lymphocytic Colitis ◽  
Small Bowel Biopsy ◽  
Major Antigen ◽  
Immunofluorescent Technique ◽  
Endomysium Antibody

Both collagenous and lymphocytic colitis have been described in patients with celiac disease, suggesting an association between the conditions. Over the past few years, the availability, sensitivity and specificity of serological markers for celiac disease have improved - the most recent advancement being the description of tissue transglutaminase as the major antigen for endomysium antibody. A quantitative ELISA was used to measure titres of immunoglobulin A (IgA) antibody to tissue transglutaminase (tTG) along with an immunofluorescent technique for IgA endomysium antibody (EmA) in 15 patients with lymphocytic colitis and eight with collagenous colitis to determine whether celiac disease latency could be detected. One patient with lymphocytic colitis demonstrated both elevated titres of tTG antibody and positive EmA, and small bowel biopsy confirmed celiac disease. One patient with collagenous colitis had a slightly elevated titre of tTG antibody with a negative EmA, and results of a small bowel biopsy were normal. Three other patients with lymphocytic colitis were already treated for previously diagnosed celiac disease. The prevalence of celiac disease occurring in lymphocytic colitis was found to be 27%, but no cases of celiac disease in association with collagenous colitis were found.

scholarly journals Lymphocytic colitis: clinical presentation and long term course

Gut ◽  
1998 ◽  
Vol 43 (5) ◽  
pp. 629-633 ◽  
Author(s):  
B Mullhaupt ◽  
U Güller ◽  
M Anabitarte ◽  
R Güller ◽  
M Fried
Keyword(s):  
Colonic Mucosa ◽  
Clinical Presentation ◽  
Collagenous Colitis ◽  
Endoscopic Examination ◽  
Watery Diarrhoea ◽  
Lymphocytic Colitis ◽  
Radiological Findings ◽  
Benign Course

Background—Lymphocytic colitis is characterised by chronic watery diarrhoea with normal endoscopic or radiological findings and microscopic evidence of pronounced infiltration of the colonic mucosa with lymphocytes.Aim—To investigate the long term clinical and histological evolution of the disease in a large group of patients with well characterised lymphocytic colitis.Methods—Between 1986 and 1995 the histological diagnosis of lymphocytic colitis was obtained in 35 patients; 27 of these agreed to a follow up examination. All clinical, endoscopic, and histopathological records were reviewed at that time and the patients had a second endoscopic examination with follow up biopsies.Results—The patients initially presented with the typical findings of lymphocytic colitis. After a mean (SD) follow up of 37.8 (27.5) months, diarrhoea subsided in 25 (93%) and histological normalisation was observed in 22 (82%) of the 27 patients. Progression from lymphocytic colitis to collagenous colitis was not observed.Conclusions—Lymphocytic colitis is characterised by a benign course with resolution of diarrhoea and normalisation of histology in over 80% of patients within 38 months. Considering the benign course of the disease, the potential benefit of any drug treatment should be carefully weighed against its potential side effects.

COLLAGENOUS COLITIS AND LYMPHOCYTIC COLITIS

1994 ◽  
Vol 45 (1) ◽  
pp. 105-118 ◽  
Author(s):  
John M. Zeroogian, M.D ◽  
Sanjiv Chopra, M.D
Keyword(s):  
Collagenous Colitis ◽  
Lymphocytic Colitis

scholarly journals Lymphocytic colitis: a distinct clinical entity? A clinicopathological confrontation of lymphocytic and collagenous colitis

Gut ◽  
1999 ◽  
Vol 45 (3) ◽  
pp. 375-381 ◽  
Author(s):  
F Baert ◽  
K Wouters ◽  
G D’Haens ◽  
P Hoang ◽  
S Naegels ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Clinical Features ◽  
Collagenous Colitis ◽  
Lymphocytic Colitis ◽  
Histological Findings ◽  
Drug Induced ◽  
Duration Of Symptoms ◽  
Histological Features ◽  
Autoimmune Conditions ◽  
Inflammatory Drugs

BACKGROUND AND AIMSIt is not known whether lymphocytic colitis and collagenous colitis represent different clinical entities or constitute part of a spectrum of disease.METHODSDetailed clinical features and histological findings were compared in a large series of patients with confirmed lymphocytic and collagenous colitis.RESULTSHistological diagnosis was confirmed in 96 patients with collagenous colitis and 80 with lymphocytic colitis. Twenty eight per cent of patients with collagenous colitis and 26% of patients with lymphocytic colitis had overlapping but less pronounced histological features. Both groups were equal in terms of age, use of aspirin and non-steroidal anti-inflammatory drugs, associated autoimmune conditions, arthritis, diarrhoea, and abdominal pain. The male:female ratio was 27:73 for collagenous colitis and 45:55 for lymphocytic colitis (p=0.013). Twenty five per cent of patients with collagenous colitis compared with 14% of patients with lymphocytic colitis were active smokers; only 8.3% of patients with collagenous colitis had stopped smoking compared with 23% of patients with lymphocytic colitis (p=0.013). Drug induced disease was suspected for ticlopidine (two collagenous colitis, four lymphocytic colitis) and flutamide (four lymphocytic colitis). Mean duration of symptoms before diagnosis was two months for lymphocytic colitis and four months for collagenous colitis. Overall prognosis was generally mild; 84% of patients with lymphocytic colitis and 74% of patients with collagenous colitis reported resolution or significant improvement (p=0.033).CONCLUSIONSCollagenous and lymphocytic colitis are similar but not identical. Patients with lymphocytic colitis present somewhat earlier and are less likely to be active smokers. Symptoms are milder and more likely to disappear in lymphocytic colitis. Ticlopidine and flutamide should be added to the list of drugs inducing colitis.

scholarly journals Perinuclear Antineutrophil Cytoplasmic Antibodies in Collagenous or Lymphocytic Colitis with or without Celiac Disease

1997 ◽  
Vol 11 (5) ◽  
pp. 417-420 ◽  
Author(s):  
Hugh James Freeman
Keyword(s):  
Ulcerative Colitis ◽  
Risk Factor ◽  
Celiac Disease ◽  
Sclerosing Cholangitis ◽  
Collagenous Colitis ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Lymphocytic Colitis ◽  
Heterogeneous Nature ◽  
Assay Result ◽  
First Time

Microscopic forms of colitis, including lymphocytic and collagenous colitis, have been observed in both those with and without celiac disease. Although perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) occur in most patients with ulcerative colitis, investigations in microscopic, particularly lymphocytic, colitis are still needed. In this study atypical p-ANCA was evaluated in 55 patients, including 27 with celiac disease alone, 13 with celiac disease and concomitant lymphocytic colitis, and 15 with microscopic forms of colitis, including lymphocytic and collagenous colitis. Nine patients (16.3%) had atypical p-ANCA, including six with celiac disease and three with a microscopic form of colitis alone. Although five of the six positive celiac disease patients had lymphocytic colitis, all three celiac disease patients with associated primary sclerosing cholangitis - a separate risk factor for a positive assay result - were serologically positive for atypical p-ANCA. These results indicate for the first time that this serological marker may occur in histologically defined celiac disease with or without concomitant lymphocytic colitis. Furthermore, these results suggest that the pathogenesis of ulcerative colitis differs from that of lymphocytic colitis and further emphasizes the heterogeneous nature of these newly recognized types of colonic inflammatory mucosal disorders.

Sign in / Sign up

Export Citation Format

Share Document