Pathology of Chronic Humoral Rejection

2008 ◽  
pp. 75-86 ◽  
Author(s):  
Robert B. Colvin
Keyword(s):  
Humoral Rejection

scholarly journals Is ABO-Incompatible Living Donor Liver Transplantation Really a Good Alternative for Pediatric Recipients?

Children ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 600
Author(s):  
Catherine de Magnée ◽  
Louise Brunée ◽  
Roberto Tambucci ◽  
Aurore Pire ◽  
Isabelle Scheers ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Solid Organ Transplantation ◽  
Solid Organ ◽  
Humoral Rejection ◽  
Donor Liver ◽  
Retrospective Case ◽  
Donor Liver Transplantation ◽  
Antibody Mediated Rejection

Background: ABO-incompatible (ABOi) living donor liver transplantation (LDLT) has been proposed to compensate for donor shortage. To date, few studies have reported detailed ABOi LDLT results in large series of pediatric patients. C4d complement deposition in graft capillaries has been reported to be associated with antibody-mediated rejection in solid organ transplantation. Methods: A retrospective case–control study was conducted, comparing clinical outcomes of each of 34 consecutive pediatric ABOi LDLT recipients with those of 2 non-ABOi pairs (n = 68), matched according to pre-transplant diagnostic criteria, age, and date of transplantation. In addition, we studied the C4d immunostaining pattern in 22 ABOi and in 36 non-ABOi recipients whose liver biopsy was performed within the first 4 post-transplant weeks for suspected acute rejection. Results: The incidence of biliary complications was higher in ABOi recipients (p < 0.05), as were the incidence of acute humoral rejection (p < 0.01) and the incidence of retransplantation (p < 0.05). All children who required retransplantation were older than 1 year at the time of ABOi LDLT. Positive C4d immunostaining was observed in 13/22 (59%) ABOi recipients versus 3/36 (8.3%) non-ABOi recipients (p < 0.0001). Conclusions: ABOi LDLT is a feasible option for pediatric end-stage liver disease but carries increased risks for the recipient, especially for children older than 1 year, even with a specific preparation protocol. C4d immunostaining may be a hallmark of acute humoral rejection in ABOi liver transplantation.

ACUTE HUMORAL REJECTION AFTER HEART TRANSPLANTATION

1988 ◽  
Vol 46 (4) ◽  
pp. 603-604 ◽  
Author(s):  
GEORGE JAMBROES ◽  
JAN C. C. BORLEFFS ◽  
PIETER J. SLOOTWEG ◽  
FRITS H. J. GMELIG MEYLING ◽  
GIJSBERT C. DE GAST
Keyword(s):  
Heart Transplantation ◽  
Humoral Rejection

scholarly journals Rat-to-Chinese tree shrew heart transplantation is a novel small animal model to study non-Gal-mediated discordant xenograft humoral rejection

2015 ◽  
Vol 22 (6) ◽  
pp. 468-475 ◽  
Author(s):  
WeiLi Chen ◽  
Yuan Wu ◽  
Akira Shimizu ◽  
YinLong Lian ◽  
Masayuki Tasaki ◽  
...  
Keyword(s):  
Animal Model ◽  
Heart Transplantation ◽  
Tree Shrew ◽  
Small Animal ◽  
Humoral Rejection ◽  
Small Animal Model

Impact of rituximab therapy for treatment of acute humoral rejection

2009 ◽  
Vol 23 (1) ◽  
pp. 63-73 ◽  
Author(s):  
Z. Kaposztas ◽  
H. Podder ◽  
S. Mauiyyedi ◽  
O. Illoh ◽  
R. Kerman ◽  
...  
Keyword(s):  
Humoral Rejection

scholarly journals Polyreactive Antibodies Developing Amidst Humoral Rejection of Human Kidney Grafts Bind Apoptotic Cells and Activate Complement

2013 ◽  
Vol 13 (10) ◽  
pp. 2590-2600 ◽  
Author(s):  
F. Porcheray ◽  
J. W. Fraser ◽  
B. Gao ◽  
A. McColl ◽  
J. DeVito ◽  
...  
Keyword(s):  
Human Kidney ◽  
Apoptotic Cells ◽  
Humoral Rejection ◽  
Polyreactive Antibodies

Immunology of Cellular and Humoral Rejection after Cardiac Transplantation

2001 ◽  
pp. 21-47
Author(s):  
Marlene L. Rose ◽  
Sudhir Kushwaha ◽  
Deirdre Cunningham
Keyword(s):  
Cardiac Transplantation ◽  
Humoral Rejection

scholarly journals MO065DIAGNOSTIC CRITERIA OF HUMORAL REJECTION IN RENAL TRANSPLANT RECIPIENTS WITH PRE-EXISTING ANTI-HLA ANTIBODIES BASED ON SENTINEL SKIN FLAP BIOPSY

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Denis Sadouski ◽  
Aleh Kalachyk ◽  
Alexadr Nosik ◽  
Aliaksei Narbin ◽  
Anna Startsava ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Vascular Bundle ◽  
Renal Allograft ◽  
Skin Flap ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Humoral Rejection ◽  
Hla Antibodies ◽  
Kidney Allograft

Abstract Background and Aims Twenty years of transplantation of composite vascularised allografts have revealed the high immunogenicity of the constituent parts, especially the skin.Several researchers have proposed the use of vascular stalk flaps, which allow to performe skin biopsy and diagnose rejection without biopsy of the transplanted solid organ.Pre-existing anti-HLA antibodies represent a serious immunological barrier to successful kidney transplantation.We are not aware of any studies on the diagnosis of antibody-associated acute kidney allograft rejection from deceased donors in recipients with pre-existing antibodies, based on morphological examination of a sentinel skin flap on a vascular stalk. The Aim: To determine the morphological features of humoral rejection in renal transplant recipients with pre-existing anti-HLA antibodies based on sentinel skin flap biopsy. Method Three skin-kidney allografts recipients underwent skin flap biopsy on 2nd day after transplantation. A kidney allograft biopsy was performed on day 7, 30, 60, 90.The results of morphological studies are presented using the Banff classification of renal allograft and skin allograft pathology. All recipients were female; 35, 44, and 57 years old. Two patients were re-transplanted and the main cause of CKD was chronic glomerulonephritis. The third patient, with congenital abnormality of the urinary tract, received her first graft.Pre-existing anti-HLA antibody levels before transplantation were 50%, 60%, 80%, respectively. Results All recipients showed signs of humoral rejection of the skin flap with thrombosis of the feeding vascular bundle, phlebitis, predominantly intimal arteritis with median necrosis, detachment and areactive necrosis of epidermis and epithelium of skin appendages. Clinical rejection, similar to the algorithm proposed by Etra J.W. et al. to assess preclinical skin rejection in an animal model (2019), was interpreted as G2 in two cases and G3 in one case. The Banff classification of the skin flap offers a qualitative assessment of certain biopsy parameters, while the kidney graft has qualitative-quantitative criteria for assessing rejection. When comparing the two classifications, a quantitative gradation of pathological changes in the skin flap according to the parameter of intimal arteritis (v) and immunoreactivity of the C4d marker similar to renal rejection was possible. In histological examination of skin flap biopsies, the degree of vasculitis was assessed in a large feeding artery: in all three cases this parameter was equal to v3. C4d expression was analyzed in the endothelium of microcirculatory blood vessels of the dermis and hypodermis: C4d1 in one case and C4d3 in the other two. The analysis of renal allograft biopsies revealed signs of humoral rejection (v1) only at day 30 in two recipients whose C4d expression in the skin and hypodermis was strong (C4d3). Conclusion Antibody-mediated rejection of a vascularized sentinel skin flap in recipients with combined skin-kidney transplantation is characterized by vasculitis affecting a core vascular bundle in the form of endarteritis with necrosis of media,phlebitis and associated thrombosis.Further studies are required to determine the feasibility of using a vascular stalked skin flap in the diagnosis of humoral rejection after renal transplantation.

228: Optimizing Aerosolized Tacrolimus To Prevent Cellular and Humoral Rejection

2008 ◽  
Vol 27 (2) ◽  
pp. S142-S143 ◽  
Author(s):  
S. Schrepfer ◽  
T. Deuse ◽  
J. Fink ◽  
M. Haddad ◽  
R.C. Robbins
Keyword(s):  
Humoral Rejection

C4d DEPOSITION IN PERITUBULAR CAPILLARIES OF RENAL ALLOGRAFTS: THE MORPHOLOGY AND IMMUNOPHENOTYPE OF ACUTE HUMORAL REJECTION.

2000 ◽  
Vol 69 (Supplement) ◽  
pp. S402 ◽  
Author(s):  
S. Mauiyyedi ◽  
M. Crespo ◽  
M. Pascual ◽  
A. B. Collins ◽  
S. Saidman ◽  
...  
Keyword(s):  
Humoral Rejection ◽  
Renal Allografts ◽  
Peritubular Capillaries
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