Response of Alkaline Phosphatase to Zinc Repletion in Hypozincemic Hemodialysis Patients

1985 ◽  
Vol 3 (4) ◽  
pp. 192-198 ◽  
Author(s):  
G. Stammler ◽  
P. Klooker ◽  
J. Bommer ◽  
T. Ziegler ◽  
W. Fiehn ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Hemodialysis Patients ◽  
Zinc Repletion

scholarly journals Parathormone and bone-specific alkaline phosphatase for the follow-up of bone turnover in hemodialysis patients: Is it so simple?

2013 ◽  
Vol 417 ◽  
pp. 35-38 ◽  
Author(s):  
Pierre Delanaye ◽  
Bernard E. Dubois ◽  
François Jouret ◽  
Jean-Marie Krzesinski ◽  
Olivier Moranne ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Turnover ◽  
Hemodialysis Patients ◽  
Specific Alkaline Phosphatase ◽  
Bone Specific Alkaline Phosphatase

scholarly journals Comparison between bone alkaline phosphatase immunoassay and electrophoresis technique in hemodialysis patients

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Neda Milinković ◽  
Marija Sarić Matutinović ◽  
Svetlana Pejanović ◽  
Svetlana Ignjatović
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Alkaline Phosphatase ◽  
Hemodialysis Patients ◽  
Cusum Test ◽  
Agar Gel ◽  
Agar Gel Electrophoresis ◽  
Automated Methods ◽  
Electrophoresis Technique ◽  
Total Alkaline ◽  
Good Agreement

Summary Background Problem of the variability between the different methods using for bone alkaline phosphatase (bALP) determination greately influences the clinical significance of bALP as direct marker of bone metabolism. The aim of this study was to compare immunoassay with electrophoresis technique for bALP determination. Methods We measured bALP in 71 patients on hemodialysis with agar gel electrophoresis (ISO-PAL, SEBIA) and immunoassay (OSTASE, Beckman Coulter). Results The analyzed methods showed significant correlation (Spearman’s rho: 0.776, P < 0.01), but we found statistically significant (P < 0.01) positive bias (27%) for the results measured by immunoassay. In support of this, using electrophoresis technique we have detected presence of the intestinal isoenzymes of alkaline phosphatase in 55% of patients with median value of 30% of the total alkaline phoshatase and presence of liver-2 alkaline phosphatase isoform in 42% of patients with median value of 16.6%. The Kendall’s W of 0.787 (P<0.0001) revealed significant concordance between two analysed methods. Cusum test showed no significant deviation from linearity (P=0.850). Conclusions Despite good agreement between immunoassay methods and electrophoresis technique for bALP determination, interchangeability between these two methods is questionable. Although immunoassays are increasingly used, as fully automated methods, in a large number of laboratories and become routine methods for bALP determination, it should be beared in mind, besides various interferences, also the heterogeneity of the bALP itself, especially in patients on hemodialysis.

scholarly journals Multiple forms of alkaline phosphatase in plasma of hemodialysis patients

1991 ◽  
Vol 37 (6) ◽  
pp. 783-784 ◽  
Author(s):  
Marc E De Broe ◽  
Viviane O Van Hoof
Keyword(s):  
Alkaline Phosphatase ◽  
Hemodialysis Patients ◽  
Multiple Forms

Clinical and Radiological Features of Bone Disease in Long-Term (15 or more years) Hemodialysis Patients

1993 ◽  
Vol 16 (10) ◽  
pp. 704-710 ◽  
Author(s):  
P.L. Bedani ◽  
C. Orzincolo ◽  
A. Storari ◽  
L. Perini ◽  
S. Soffritti ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Parathyroid Hormone ◽  
Hemodialysis Patients ◽  
X Rays ◽  
Hip Joints ◽  
Radiological Features ◽  
Calcium Phosphorus ◽  
Long Term Survivors ◽  
Dialytic Treatment

Fifteen patients on regular dialytic treatment for more than 15 years were given X-rays of the skull, spine, shoulders, wrists, pelvis and knees with the purpose of studying the principal skeletal and articular alterations due or not due to the uraemic status. Serum calcium, phosphorus, parathyroid hormone, alkaline phosphatase and basal aluminium were recorded. Osteopenia was evident in all the patients. Ten of whom (67%) showed alterations due to hyperparathyroidism. Nine patients presented the marks of dialysis spondyloarthropathy; in 14/15 cases geodes were present in the wrists, humeral heads or hip-joints; in ten patients there were multiple amyloid lesions. Two patients with serum basal aluminum above 100 μg/L showed the typical radiographic marks of osteomalacia. The majority of the long-term survivors showed multifactorial osteo-articular alterations resulting mainly from the combination of hyperparathyroidism and dialysis-related amyloidosis. The less frequent joint alterations were represented by arthrosis, enthesopathy and Chondrocalcinosis. Disability and decreased articular mobility resulted in being mainly due to amyloid osteo-arthropathy.

Bone Alkaline Phosphatase besides Intact Parathyroid Hormone in Hemodialysis Patients – Any Advantage?

2005 ◽  
Vol 101 (3) ◽  
pp. c122-c127 ◽  
Author(s):  
Cristina Jorge ◽  
Célia Gil ◽  
Marília Possante ◽  
Eugénia Silva ◽  
Rui Andrade ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Parathyroid Hormone ◽  
Bone Alkaline Phosphatase ◽  
Hemodialysis Patients ◽  
Intact Parathyroid Hormone
Sign in / Sign up

Export Citation Format

Share Document