Long-term sensitization in Aplysia: biophysical correlates in tail sensory neurons

Science ◽  
1987 ◽  
Vol 235 (4789) ◽  
pp. 685-687 ◽  
Author(s):  
K. Scholz ◽  
J. Byrne
Keyword(s):  
Sensory Neurons

Sensory Neurons With Activated Caspase-3 Survive Long-Term Experimental Diabetes

Diabetes ◽  
2003 ◽  
Vol 52 (9) ◽  
pp. 2363-2371 ◽  
Author(s):  
C. Cheng ◽  
D. W. Zochodne
Keyword(s):  
Sensory Neurons ◽  
Caspase 3 ◽  
Experimental Diabetes

scholarly journals Induction of long-term facilitation in Aplysia sensory neurons by local application of serotonin to remote synapses

1993 ◽  
Vol 90 (23) ◽  
pp. 11411-11415 ◽  
Author(s):  
G A Clark ◽  
E R Kandel
Keyword(s):  
Gene Expression ◽  
Sensory Neurons ◽  
Cell Body ◽  
Sensory Cells ◽  
Target Cells ◽  
Synaptic Terminals ◽  
Dissociated Cell Culture ◽  
Synaptic Changes ◽  
Long Term Facilitation

Long-term synaptic facilitation at the connections of Aplysia sensory neurons onto their target cells involves alterations in gene expression. How then are the relevant cellular signals for the induction and expression of long-term synaptic changes conveyed between the nucleus and remote synaptic terminals? We have explored this question using a set of remote, peripheral terminals of siphon sensory cells, which are approximately 3 cm from the sensory cell body in the abdominal ganglion. We found that these remote synapses, like the proximal synapses previously studied in dissociated cell culture, can exhibit long-term facilitation 24 hr after cell-wide serotonin application. Furthermore, serotonin applications restricted to the remote synaptic terminals nevertheless produced long-term facilitation, indicating that signals generated in synaptic regions can trigger the long-term process, perhaps via retrograde signals to the nucleus to modify gene expression, followed by anterograde signals back to the terminal. Serotonin applications restricted to the cell body and proximal synapses of the sensory neuron also produced long-term facilitation at remote synapses, although to a lesser extent, suggesting that long-term facilitation is expressed cell-wide, but that superimposed on this cell-wide facilitation there appears to be a component that is synapse-specific.

Long-term cell culture of electrically active sensory neurons free of glial cells

1977 ◽  
Vol 5 (3-4) ◽  
pp. 153-157 ◽  
Author(s):  
Ellen Rieske ◽  
Georg W. Kreutzberg
Keyword(s):  
Cell Culture ◽  
Sensory Neurons ◽  
Glial Cells

Cyclic GMP pathway is critical for inducing long–term sensitization of nociceptive sensory neurons

10.1038/4520 ◽  
1999 ◽  
Vol 2 (1) ◽  
pp. 18-23 ◽  
Author(s):  
Matthew R. Lewin ◽  
Edgar T. Walters
Keyword(s):  
Sensory Neurons ◽  
Cyclic Gmp

A regulatory subunit of the cAMP-dependent protein kinase down-regulated in aplysia sensory neurons during long-term sensitization

Neuron ◽  
1992 ◽  
Vol 8 (2) ◽  
pp. 387-397 ◽  
Author(s):  
Peter J. Bergold ◽  
Sven A. Beushausen ◽  
Todd C. Sacktor ◽  
Stephen Cheley ◽  
Hagan Bayley ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Sensory Neurons ◽  
Regulatory Subunit ◽  
Dependent Protein Kinase ◽  
Camp Dependent Protein Kinase ◽  
Dependent Protein

Long-term depression of Aplysia sensorimotor synapses in cell culture: inductive role of a rise in postsynaptic calcium

1996 ◽  
Vol 76 (3) ◽  
pp. 2111-2114 ◽  
Author(s):  
X. Y. Lin ◽  
D. L. Glanzman
Keyword(s):  
Cell Culture ◽  
Synaptic Plasticity ◽  
Sensory Neurons ◽  
Tetraacetic Acid ◽  
Short Term ◽  
Long Term Depression ◽  
Central Synapses ◽  
Postsynaptic Calcium

1. Activation of sensory neurons at 2 Hz for 15 min induces long-term depression (LTD) of isolated Aplysia sensorimotor synapses in cell culture. 2. Prior infusion of the Ca2+ chelator 1,2-bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid (BAPTA) into the postsynaptic motor neuron blocks the induction of LTD, but not short-term synaptic depression. 3. Invertebrate central synapses possess the capacity for LTD. This form of long-term synaptic plasticity may play an important role in learning in Aplysia.

scholarly journals ApTrkl, a Trk-like Receptor, Mediates Serotonin- Dependent ERK Activation and Long-Term Facilitation in Aplysia Sensory Neurons

Neuron ◽  
2004 ◽  
Vol 44 (4) ◽  
pp. 715-728 ◽  
Author(s):  
Jake Ormond ◽  
Jonathan Hislop ◽  
Yali Zhao ◽  
Neil Webb ◽  
Francois Vaillaincourt ◽  
...  
Keyword(s):  
Sensory Neurons ◽  
Erk Activation ◽  
Long Term Facilitation
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