Tumor Markers in Uremia: Carcinoembryonic Antigen, Neuron-Specific Enolase, Carbohydrate Antigen CA-50 and α-Fetoprotein

1986 ◽  
Vol 6 (6) ◽  
pp. 458-463 ◽  
Author(s):  
Natale G. DeSanto ◽  
Saturnina Veneroso ◽  
Giuseppe Capodicasa ◽  
Antonello Crisci ◽  
Carmelo Giordano
Keyword(s):  
Carcinoembryonic Antigen ◽  
Tumor Markers ◽  
Neuron Specific Enolase ◽  
Carbohydrate Antigen ◽  
Alpha Fetoprotein ◽  
Ca 50

Tumor Markers in Patients with Chronic Renal Failure

1990 ◽  
Vol 5 (2) ◽  
pp. 85-88 ◽  
Author(s):  
X. Filella ◽  
A. Cases ◽  
R. Molina ◽  
J. Jo ◽  
J.L. Bedini ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Tumor Markers ◽  
Specific Antigen ◽  
Neuron Specific Enolase ◽  
Serum Levels ◽  
Carbohydrate Antigen ◽  
Ca 125 ◽  
Renal Metabolism ◽  
Ca 50

In order to evaluate the specificity of tumor markers in chronic renal failure, we have determined serum levels of carcinoembryonic antigen (CEA), carbohydrate antigen 19.9 (CA 19.9), carbohydrate antigen 50 (CA 50), alfafetoprotein (AFP), neuron-specific enolase (NSE), prostatic acid phosphatase (PAP), prostatic specific antigen (PSA), squamous cell carcinoma antigen (SCC), carbohydrate antigen 15.3 (CA 15.3) and carbohydrate antigen 125 (CA 125) in 30 patients with cronic renal failure and in 36 hemodialyzed patients without clinical evidence of neoplasia. CEA, CA 50, NSE and SCC frequently show increased serum levels, suggesting a renal metabolism, while others remain, generally, within the normal levels.

Alpha-fetoprotein, carcinoembryonic antigen, and carbohydrate antigen 19-9-producing gallbladder cancer

1996 ◽  
Vol 31 (5) ◽  
pp. 742-746 ◽  
Author(s):  
Tsuyoshi Ono ◽  
Masafumi Komatsu ◽  
Takao Hoshino ◽  
Tohru Ishii ◽  
Tomoo Fujii ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Carcinoembryonic Antigen ◽  
Carbohydrate Antigen ◽  
Alpha Fetoprotein

scholarly journals Prospective Evaluation of Carcinoembryonic Antigen (CEA) and Carbohydrate Antigen 15.3 (CA 15.3) in Patients with Primary Locoregional Breast Cancer

2010 ◽  
Vol 56 (7) ◽  
pp. 1148-1157 ◽  
Author(s):  
Rafael Molina ◽  
Jose M Auge ◽  
Blanca Farrus ◽  
Gabriel Zanón ◽  
Jaume Pahisa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Carcinoembryonic Antigen ◽  
Tumor Markers ◽  
Primary Breast Cancer ◽  
Disease Free Survival ◽  
Carbohydrate Antigen ◽  
Nodal Involvement ◽  
Total Group ◽  
Ca 15.3

Abstract Background: The utility of carcinoembryonic antigen (CEA) and carbohydrate antigen 15.3 (CA 15.3) as prognostic factors in primary breast cancer is unclear. Methods: We prospectively studied CEA and CA 15.3 in the sera of 2062 patients with untreated primary breast cancer diagnosed between 1984 and 2008. Results: Increased CEA (>5 μg/L) and CA 15.3 (>30 kU/L) concentrations were found in 12.7% and 19.6% of the patients, respectively, and 1 or both tumor markers were increased in 28% (570 of 2062). Increases in each tumor marker correlated with larger tumor sizes and nodal involvement. Tumor size, estrogen receptor (ER), and CEA were independent prognostic factors by multivariate analysis in the total group [disease free survival (DFS) and overall survival (OS)] as well as in node-positive (NP) and node-negative (NN) patients. Nodal involvement and histological grade were independent prognostic factors in the total group as well as in NP patients. By contrast, adjuvant treatment and CA 15.3 were independent prognostic factors only in NN patients (DFS and OS). All patients with CEA >7.5 μg/L had recurrence during follow-up. Use of both tumor markers allowed discrimination of the groups of risk in T1 NN patients: 56.3% of recurrences were seen when 1 or both tumor markers were increased, whereas only 9.4% of recurrences were seen in T1 NN patients without increases of either marker. Conclusions: CEA and CA 15.3 are useful prognostic factors in NP and NN breast cancer patients. CEA >7.5 μg/L is associated with a high probability of subclinical metastases.

Comparison of Serum Tumor Markers for Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma

2010 ◽  
Vol 76 (11) ◽  
pp. 1210-1213 ◽  
Author(s):  
Lian-Yuan Tao ◽  
Lei Cai ◽  
Xiao-Dong He ◽  
Wei Liu ◽  
Qiang Qu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carcinoembryonic Antigen ◽  
Tumor Markers ◽  
Intrahepatic Cholangiocarcinoma ◽  
High Specificity ◽  
Serum Levels ◽  
Diagnostic Value ◽  
Carbohydrate Antigen ◽  
Serum Tumor Markers ◽  
Preoperative Serum

Serum tumor markers such as alpha-fetoprotein (AFP), carcinoembryonic antigen, carbohydrate antigen (CA) 19-9, CA242, and CA50 were analyzed to evaluate their diagnostic values in single and combined tests for distinguishing intrahepatic cholangiocarcinoma (ICC) from hepatocellular carcinoma (HCC). Preoperative serum levels of AFP, carcinoembryonic antigen, CA19-9, CA242, and CA50 were measured in 45 ICC and 76 HCC patients. The serum levels and the positive rate of AFP, CA19-9, and CA242 were significantly different between the ICC patients and HCC patients. Although AFP (—) was the most sensitive assay for distinguishing ICC from HCC (91.1%), its specificity was significantly lower than that of CA242 (+) and CA19-9 (+). The combination of AFP (-) and CA242 (+) afforded a high specificity of 94.3 per cent and showed highest accuracy (78.5%). Evaluation of patients without liver cirrhosis also showed similar results. The diagnostic value of CA242 (+) is better than that of CA19-9 (+) and AFP (-) in distinguishing ICC from HCC. Combined detection of AFP (—) and CA242 (+) can improve the specificity and accuracy of diagnosing ICC.

scholarly journals Biological variation of serum neuron-specific enolase and carbohydrate antigen 724 tumor markers

2017 ◽  
Vol 32 (4) ◽  
pp. e22327 ◽  
Author(s):  
Shuo Wang ◽  
Min Zhao ◽  
Runqing Mu ◽  
Xin Zhang ◽  
Ke Yun ◽  
...  
Keyword(s):  
Tumor Markers ◽  
Neuron Specific Enolase ◽  
Carbohydrate Antigen ◽  
Biological Variation ◽  
Serum Neuron Specific Enolase
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