Alpha-fetoprotein, carcinoembryonic antigen, and carbohydrate antigen 19-9-producing gallbladder cancer

1996 ◽  
Vol 31 (5) ◽  
pp. 742-746 ◽  
Author(s):  
Tsuyoshi Ono ◽  
Masafumi Komatsu ◽  
Takao Hoshino ◽  
Tohru Ishii ◽  
Tomoo Fujii ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Carcinoembryonic Antigen ◽  
Carbohydrate Antigen ◽  
Alpha Fetoprotein

scholarly journals Limits of serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 as the diagnosis of gallbladder cancer

2021 ◽  
Vol 25 (1) ◽  
pp. S309-S309
Author(s):  
Jae Seung KANG ◽  
Yoo Jin CHOI ◽  
Yoonhyeong BYUN ◽  
Youngmin HAN ◽  
Jung Min LEE ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Carcinoembryonic Antigen ◽  
Carbohydrate Antigen ◽  
Serum Carcinoembryonic Antigen

Tumor Markers in Uremia: Carcinoembryonic Antigen, Neuron-Specific Enolase, Carbohydrate Antigen CA-50 and α-Fetoprotein

1986 ◽  
Vol 6 (6) ◽  
pp. 458-463 ◽  
Author(s):  
Natale G. DeSanto ◽  
Saturnina Veneroso ◽  
Giuseppe Capodicasa ◽  
Antonello Crisci ◽  
Carmelo Giordano
Keyword(s):  
Carcinoembryonic Antigen ◽  
Tumor Markers ◽  
Neuron Specific Enolase ◽  
Carbohydrate Antigen ◽  
Alpha Fetoprotein ◽  
Ca 50

scholarly journals Limits of serum carcinoembryonic antigen and carbohydrate antigen 19-9 as the diagnosis of gallbladder cancer

2021 ◽  
Vol 101 (5) ◽  
pp. 266
Author(s):  
Jae Seung Kang ◽  
Su Young Hong ◽  
Youngmin Han ◽  
Hee Ju Sohn ◽  
Mirang Lee ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Carcinoembryonic Antigen ◽  
Carbohydrate Antigen ◽  
Serum Carcinoembryonic Antigen

scholarly journals Diagnostic Value of Serum Tumor Markers (Carcinoembryonic Antigen and Carbohydrate Antigen 19-9) in Gallbladder Cancer

HPB ◽  
2019 ◽  
Vol 21 ◽  
pp. S271-S272
Author(s):  
Su Young Hong ◽  
Hongbeom Kim ◽  
Youngmin Han ◽  
Yoonhyeong Byun ◽  
Eun Joo Kim ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Carcinoembryonic Antigen ◽  
Tumor Markers ◽  
Diagnostic Value ◽  
Carbohydrate Antigen ◽  
Serum Tumor Markers

scholarly journals Role of Tumour Markers Carbohydrate Antigen 19-9, Carcinoembryonic Antigen, & Alpha Fetoprotein in Carcinoma Gall Bladder

2021 ◽  
Vol 10 (10) ◽  
pp. 719-723
Author(s):  
Saurabh Rai ◽  
Chandra Shekhar ◽  
Osman Musa ◽  
Nisar Ansari ◽  
Rahul Agrawal ◽  
...  
Keyword(s):  
Gall Bladder ◽  
Carcinoembryonic Antigen ◽  
Bladder Carcinoma ◽  
Carbohydrate Antigen ◽  
Tumour Markers ◽  
Alpha Fetoprotein ◽  
Advanced Stage ◽  
Gall Bladder Carcinoma ◽  
Carcinoma Gall Bladder

BACKGROUND Gallbladder cancer is recognised as an irreversible malignancy with a high fatality rate. The highest incidence of gall bladder carcinoma is seen in India and Chile, and relatively low level in many Western countries. Gall bladder carcinoma has an extremely poor prognosis, increasing incidence, and diagnosed at an advanced stage despite recent advances in diagnostic modalities. Considering the high rate of mortality attributable mainly to late detection of disease at an advanced stage, early diagnosis remains to be one of the most important determinants of the outcome. This study was conducted to assess the role of tumour markers, namely carbohydrate antigen (CA 19-9), carcinoembryonic antigen (CEA) and alpha fetoprotein (AFP) in the diagnosis of gall bladder carcinoma. We wanted to assess the diagnostic role of tumour markers in carcinoma gall bladder. METHODS Patients with radiologically and histopathologically confirmed diagnosis of carcinoma gall bladder were invited to participate in the study. A thorough history was taken, and relevant examination done as per protocol. All necessary laboratory and radiologic investigations were done according to study design. Assessment of the tumour markers CA19-9, CEA and AFP was done, and values compared with carcinoma gall bladder patients. RESULTS The diagnostic value of tumour markers has been studied in context with histopathological grade as all the cases were histopathologically proven cases of carcinoma gall bladder (Ca GB). CONCLUSIONS The present study showed that CA 19-9 was most effective with regard to its ability to differentiate between different grades of gall bladder carcinoma. KEY WORDS CA 19-9, CEA, AFP, Carcinoma Gallbladder

scholarly journals Prognostic Value of Carcinoembryonic Antigen (CEA) and Carbohydrate Antigen 19-9 (CA 19-9) in Gallbladder Cancer; 65 IU/mL of CA 19-9 Is the New Cut-Off Value for Prognosis

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1089
Author(s):  
Myongjin Kim ◽  
Hongbeom Kim ◽  
Youngmin Han ◽  
Heeju Sohn ◽  
Jae Seung Kang ◽  
...  
Keyword(s):  
Overall Survival ◽  
Multivariate Analysis ◽  
Prognostic Factors ◽  
Tumor Marker ◽  
Gallbladder Cancer ◽  
Carcinoembryonic Antigen ◽  
Carbohydrate Antigen ◽  
Optimal Thresholds ◽  
The Relationship ◽  
Tree Method

Due to the lack of appropriate tumor markers with optimal cut-off values to predict the prognosis of gallbladder cancer (GBC), this study aimed to demonstrate the relationship between prognosis and the levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9), and to determine optimal thresholds. In total, 539 patients diagnosed with GBC were examined. The relationship between tumor marker levels and overall survival (OS) was analyzed. The C-tree method was used to suggest tumor marker thresholds, and multivariate analysis was conducted to identify prognostic factors for overall survival. The mean age of the patients was 65.3 years, and the 5-year overall survival rate in all patients was 68.9%. Following the C-tree method, the optimal cut-off value was set at 5 IU/mL for CEA and at 65 IU/mL for CA 19-9. Multivariate analysis revealed that age, CA 19-9 level, operative method, T stage, and N stage were significant prognostic factors for OS. Consequently, CA 19-9 had a stronger association with prognosis than CEA, and 65 IU/mL for CA 19-9 may be suggestive in evaluating the prognosis of GBC. Moreover, it could be an effective indicator for determining the surgical extent necessary and the need for adjuvant treatment.

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