Quantitative Evaluation of Anticancer Agents against Human Melanoma Cells Implanted in Nude Mice

Pathobiology ◽  
1986 ◽  
Vol 54 (3) ◽  
pp. 149-154 ◽  
Author(s):  
Arnold Lockshin ◽  
Beppino C. Giovanella ◽  
John S. Stehlin, Jr.
Keyword(s):  
Quantitative Evaluation ◽  
Nude Mice ◽  
Anticancer Agents ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cells

Selective growth of human melanoma cells in the brain parenchyma of nude mice

1996 ◽  
Vol 6 (5) ◽  
pp. 363-371 ◽  
Author(s):  
T Fujimaki ◽  
J E Price ◽  
D Fan ◽  
C D Bucana ◽  
K Itoh ◽  
...  
Keyword(s):  
Nude Mice ◽  
Melanoma Cells ◽  
Brain Parenchyma ◽  
Human Melanoma ◽  
Selective Growth ◽  
Human Melanoma Cells ◽  
The Brain

scholarly journals The chemokine RANTES is secreted by human melanoma cells and is associated with enhanced tumour formation in nude mice

1999 ◽  
Vol 79 (7-8) ◽  
pp. 1025-1031 ◽  
Author(s):  
U Mrowietz ◽  
U Schwenk ◽  
S Maune ◽  
J Bartels ◽  
M Küpper ◽  
...  
Keyword(s):  
Nude Mice ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cells ◽  
Tumour Formation

scholarly journals Synthetic Peptide ΔM4-Induced Cell Death Associated with Cytoplasmic Membrane Disruption, Mitochondrial Dysfunction and Cell Cycle Arrest in Human Melanoma Cells

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5684
Author(s):  
Gloria A. Santa-González ◽  
Edwin Patiño-González ◽  
Marcela Manrique-Moreno
Keyword(s):  
Cell Cycle ◽  
Skin Cancer ◽  
Anticancer Agents ◽  
Synthetic Peptide ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Membrane Disruption ◽  
Iodide Uptake ◽  
Human Melanoma Cells ◽  
Wide Range

Melanoma is the most dangerous and lethal form of skin cancer, due to its ability to spread to different organs if it is not treated at an early stage. Conventional chemotherapeutics are failing as a result of drug resistance and weak tumor selectivity. Therefore, efforts to evaluate novel molecules for the treatment of skin cancer are necessary. Antimicrobial peptides have become attractive anticancer agents because they execute their biological activity with features such as a high potency of action, a wide range of targets, and high target specificity and selectivity. In the present study, the antiproliferative activity of the synthetic peptide ΔM4 on A375 human melanoma cells and spontaneously immortalized HaCaT human keratinocytes was investigated. The cytotoxic effect of ΔM4 treatment was evaluated through propidium iodide uptake by flow cytometry. The results indicated selective toxicity in A375 cells and, in order to further investigate the mode of action, assays were carried out to evaluate morphological changes, mitochondrial function, and cell cycle progression. The findings indicated that ΔM4 exerts its antitumoral effects by multitarget action, causing cell membrane disruption, a change in the mitochondrial transmembrane potential, an increase of reactive oxygen species, and cell cycle accumulation in S-phase. Further exploration of the peptide may be helpful in the design of novel anticancer peptides.

Attenuation of telomerase activity does not increase sensitivity of human melanoma cells to anticancer agents

2000 ◽  
Vol 36 (16) ◽  
pp. 2137-2145 ◽  
Author(s):  
M. Folini ◽  
C. De Marco ◽  
L. Orlandi ◽  
M.G. Daidone ◽  
N. Zaffaroni
Keyword(s):  
Anticancer Agents ◽  
Telomerase Activity ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cells

Anti-cachectic effect of ghrelin in nude mice bearing human melanoma cells

2003 ◽  
Vol 301 (2) ◽  
pp. 275-279 ◽  
Author(s):  
Takeshi Hanada ◽  
Koji Toshinai ◽  
Naoko Kajimura ◽  
Noriko Nara-Ashizawa ◽  
Toshihiko Tsukada ◽  
...  
Keyword(s):  
Nude Mice ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cells

scholarly journals Antigen expression of metastasizing and non-metastasizing human melanoma cells xenografted into nude mice

1991 ◽  
Vol 9 (3) ◽  
pp. 259-272 ◽  
Author(s):  
G. N. P. Van Muijen ◽  
L. M. H. A. Cornelissen ◽  
C. F. J. Jansen ◽  
C. G. Figdor ◽  
J. P. Johnson ◽  
...  
Keyword(s):  
Nude Mice ◽  
Antigen Expression ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cells
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