scholarly journals Affinities of Adrenergic Drugs for α2-Adrenoceptors in Dog Saphenous Vein in Comparison with Those in Rat Brain or Human Platelets

1985 ◽  
Vol 22 (3) ◽  
pp. 127-138
Author(s):  
Keizo Sogabe ◽  
Hisakuni Hashimoto ◽  
Mitsuyoshi Nakashima
Keyword(s):  
Rat Brain ◽  
Saphenous Vein ◽  
Human Platelets ◽  
Dog Saphenous Vein ◽  
Adrenergic Drugs

scholarly journals Characterization of α2-adrenoceptors in human platelets, dog saphenous vein and rat brain

1984 ◽  
Vol 36 ◽  
pp. 309
Author(s):  
Keizo Sogabe ◽  
Hisakuni Hashimoto ◽  
Yoshiharu Takeguchi ◽  
Mitsuyoshi Nakashima
Keyword(s):  
Rat Brain ◽  
Saphenous Vein ◽  
Human Platelets ◽  
Dog Saphenous Vein ◽  
Α2 Adrenoceptors

Perinatal influence of β-adrenergic drugs on the noradrenergic system of the rat brain

1993 ◽  
Vol 24 (5) ◽  
pp. 1069-1078 ◽  
Author(s):  
Erna B.H.W. Erdtsieck-Ernste ◽  
Matthijs G.P. Feenstra ◽  
Gerard J. Boer
Keyword(s):  
Rat Brain ◽  
Noradrenergic System ◽  
Adrenergic Drugs

Neurochemical and Pharmacological Properties of Tianeptine, A Novel Antidepressant

1992 ◽  
Vol 160 (S15) ◽  
pp. 56-60 ◽  
Author(s):  
C. Labrid ◽  
E. Mocaër ◽  
A. Kamoun
Keyword(s):  
Rat Brain ◽  
Ex Vivo ◽  
Animal Experiments ◽  
Pyramidal Cells ◽  
Human Platelets ◽  
Clinical Findings ◽  
Tricyclic Antidepressant ◽  
Laboratory Animals ◽  
5 Ht Uptake

Tianeptine is a tricyclic antidepressant with an unusual chemical structure (a long lateral chain grafted on to a substituted dibenzothiazepin nucleus), and with biochemical and animal-behavioural properties which are strikingly different from those of classical tricyclics. Unlike the latter, which decrease serotonin (5-HT) uptake, acute and chronic tianeptine treatment enhances 5-HT uptake in rat brain and in rat and human platelets ex vivo. In vivo, tianeptine potentiates the depletion of rat brain 5-HT by 4-methyl-alpha-ethyl metatyramine and increases rat hippocampal 5-HIAA; 5-HT uptake inhibitors (e.g. fluoxetine) have opposite effects. On iontophoretic injection into CA1 pyramidal cells, tianeptine shortens the period of neuronal hypoactivity caused by GABA or 5-HT, whereas other tricyclics prolong it, and it enhances attention, learning, and memory in laboratory animals, while classical tricyclics have opposite effects. However, the relationships between these effects of tianeptine in animal experiments and their relevance to clinical findings remain to be determined.

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