Do Resistance Vessel Abnormalities Contribute to the Elevated Blood Pressure of Spontaneously-Hypertensive Rats?

1983 ◽  
Vol 20 (1) ◽  
pp. 1-22 ◽  
Author(s):  
M.J. Mulvany
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Elevated Blood Pressure ◽  
Elevated Blood ◽  
Hypertensive Rats ◽  
Resistance Vessel ◽  
Spontaneously Hypertensive

Effect of Chronic Clonidine Treatment and its Abrupt Cessation on Mean Blood Pressure of Rats with a Normal or An Elevated Blood Pressure

1979 ◽  
Vol 57 (2) ◽  
pp. 195-201 ◽  
Author(s):  
J. Atkinson ◽  
Nicole Boillat ◽  
Roselyne Pera-Bally ◽  
Lise Peters-Haefeli ◽  
E. J. Kirchertz
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Early Stage ◽  
Mean Blood Pressure ◽  
Average Dose ◽  
Elevated Blood ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Induced Hypertension ◽  
Drinking Fluid

1. Clonidine (6 mg of base/1 of water) was given as drinking fluid to normotensive rats or rats with established or early hypertension. 2. Spontaneous hypertensive rats (6 months old: average dose of clonidine, 0·6 mg 24 h−1 kg−1) showed a sustained fall in blood pressure over 3 weeks. 3. The same clonidine solution given for 6 weeks to two-kidney Goldblatt rats with early-stage hypertension (average dose of clonidine: 1 mg 24 h−1 kg−1) or spontaneously hypertensive rats (clonidine dose: 1 mg) induced a fall in mean blood pressure, but no change in normotensive rats. 4. Replacement of clonidine by water induced hypertension and lability which led to death in hypertensive but not in normotensive rats.

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