High-Molecular-Weight Adiponectin and Leptin Levels in Cord Blood Are Associated with Anthropometric Measurements at Birth

2008 ◽  
Vol 70 (5) ◽  
pp. 268-272 ◽  
Author(s):  
Makoto Inoue ◽  
Kazuo Itabashi ◽  
Yuya Nakano ◽  
Yasuko Nakano ◽  
Takashi Tobe
Keyword(s):  
Molecular Weight ◽  
Cord Blood ◽  
High Molecular Weight ◽  
Anthropometric Measurements ◽  
High Molecular Weight Adiponectin

scholarly journals Correlation of High-Molecular-Weight Adiponectin and Leptin Concentrations with Anthropometric Parameters and Insulin Sensitivity in Newborns

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Jia Zheng ◽  
Xinhua Xiao ◽  
Qian Zhang ◽  
Lili Mao ◽  
Ming Li ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Insulin Sensitivity ◽  
Cord Blood ◽  
High Molecular Weight ◽  
Linear Regression Analysis ◽  
Anthropometric Measurements ◽  
Multivariate Linear Regression Analysis ◽  
High Molecular Weight Adiponectin ◽  
College Hospital ◽  
Hmw Adiponectin

Objective. High-molecular-weight adiponectin (HMW-adiponectin) and leptin are two important adipokines. The aim of this study was to examine the association between the two adipokines and anthropometric measurements of neonates at birth. Furthermore, we would like to explore whether HMW-adiponectin and leptin correlate with insulin sensitivity in neonates.Methods. Venous cord blood samples were obtained from 266 full-term healthy neonates consecutively born at Peking Union Medical College Hospital. HMW-adiponectin, leptin, blood glucose, and insulin concentrations were measured.Results. HMW-adiponectin and leptin were significantly higher in females compared with males (P=0.031andP=0.000, resp.). Univariate correlation analysis showed that leptin concentrations in cord blood were positively associated with gestational age, birth weight, body length, ponderal index, placenta weight, insulin, and insulin sensitivity (allP<0.001). However, there was no correlation between cord blood HMW-adiponectin levels and foetal anthropometric measurements or foetal insulin sensitivity indicators (allP>0.05). Multivariate linear regression analysis indicated that leptin (B=-0.126,P=0.045) in cord blood was independently associated with insulin sensitivity.Conclusions. Leptin concentrations, but not HMW-adiponectin, were positively associated with foetal anthropometric measurements. Leptin concentrations are significantly associated with foetal insulin sensitivity, and there were no significant correlations between HMW-adiponectin levels and foetal insulin sensitivity.

Sexual dimorphism of high molecular weight adiponectin in cord blood

2009 ◽  
Vol 70 (3) ◽  
pp. 500-501 ◽  
Author(s):  
Sue Mei Lau ◽  
Tien Ming Hng ◽  
Brad de Vries ◽  
Mark McLean ◽  
N Wah Cheung
Keyword(s):  
Molecular Weight ◽  
Sexual Dimorphism ◽  
Cord Blood ◽  
High Molecular Weight ◽  
High Molecular Weight Adiponectin

scholarly journals Associations between Maternal and Fetal Levels of Total Adiponectin, High Molecular Weight Adiponectin, Selected Somatomedins, and Birth Weight of Infants of Smoking and Non-Smoking Mothers

2020 ◽  
Vol 17 (13) ◽  
pp. 4781 ◽  
Author(s):  
Magdalena Chełchowska ◽  
Joanna Gajewska ◽  
Tomasz M. Maciejewski ◽  
Joanna Mazur ◽  
Mariusz Ołtarzewski ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Birth Weight ◽  
Growth Factor ◽  
Cord Blood ◽  
High Molecular Weight ◽  
Umbilical Cord Blood ◽  
High Molecular Weight Adiponectin ◽  
Hmw Adiponectin ◽  
Total Adiponectin ◽  
Igf I

The aim of the study was to determine the relationships between maternal smoking, total adiponectin, high molecular weight adiponectin (HMW adiponectin), selected somatomedins, and the birth weight of newborns. A total of 78 women with a healthy, singleton pregnancy, 41 active smokers and 37 non-smokers, and their offspring were studied. Total and HMW adiponectin, insulin-like growth factor I (IGF-I), and insulin-like growth factor binding protein-1 (IGFBP-1) and 2 (IGFBP-2) were determined in maternal and cord blood by enzyme-link immunosorbent assay. Serum levels of total and HMW adiponectin were lower in smokers compared to the tobacco abstinent in both the mothers (p = 0.013; p = 0.006) and the infants (p = 0.001; p = 0.047). In smoking women and their children, serum concentrations of IGF-I were significantly lower (p = 0.014; p = 0.042), IGFBP-1 significantly higher (p = 0.009; p = 0.039), and IGFBP-2 did not differ from that observed in the non-smoking group. In multivariate analysis performed on the whole group of mothers, the highest impact of serum cotinine and IGFBP-2 levels were indicated for adiponectin and cotinine and the number of cigarettes/day for HMW adiponectin concentration. In correlation analysis estimated separately for smokers and non-smokers, neonatal birth weight was positively associated with total and HMW adiponectin concentrations in umbilical cord blood. Birth weight was also inversely associated with IGFBP-1 and positively correlated with IGF-I levels in maternal serum as well as in cord blood (r = −0.317, p = 0.005; r = −0.294, p = 0.004; r = 0.245, p = 0.031; r = 0.271, p = 0.009, respectively). The present study showed the levels of total and HMW adiponectin in umbilical cord blood may have a significant effect on fetal development. Both IGF-I and IGFBP-1 concentrations also play an essential role in fetal growth, which is an important predictor of birth weight. Cigarette smoking during pregnancy negatively affected adiponectin and the insulin growth factor profile in the serum of women and the cord blood and may be the reason for the lower birth weight of the smokers newborns compared with the nonsmokers offspring.

scholarly journals Acute and Short-term Chronic Testosterone Fluctuation Effects on Glucose Homeostasis, Insulin Sensitivity, and Adiponectin: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

2014 ◽  
Vol 99 (6) ◽  
pp. E1088-E1096 ◽  
Author(s):  
Christian Høst ◽  
Lars C. Gormsen ◽  
David M. Hougaard ◽  
Jens S. Christiansen ◽  
Steen B. Pedersen ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Glucose Metabolism ◽  
Crossover Study ◽  
High Molecular Weight ◽  
Glucose Disposal ◽  
Short Term ◽  
High Molecular Weight Adiponectin ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Total Glucose

Context: Low levels of adiponectin and T in men have been shown to predict development of the metabolic syndrome, but the effects of T on glucose metabolism are incompletely understood and may be influenced either directly or indirectly through changes in body composition or in levels of adiponectin. Objective: The aim of the study was to test whether T exerts its effects on glucose metabolism directly or indirectly. Design, Setting, and Participants: In a randomized, double-blind, placebo-controlled, crossover study, 12 healthy young males were studied on four separate occasions. They received GnRH agonist treatment 1 month before 3 of 4 trial days to induce castrate levels of T. On trial days, T gel containing either high or low physiological T dose or placebo was applied to the body. On a fourth trial day, participants constituted their own eugonadal controls. Intervention: Each study comprised a 5-hour basal period and a 3-hour hyperinsulinemic euglycemic clamp. Main Outcome Measures: We measured the effect of acute T on peripheral glucose disposal, total adiponectin and subforms, and other indices of glucose metabolism. Results: Short-term hypogonadism was associated with increased high molecular weight adiponectin levels (P &lt; .03) and increased oxidative glucose disposal (P = .03) but not total glucose disposal (P = .07). Acute T treatment was an independent suppressor of high molecular weight adiponectin levels (P = .04) but did not affect total glucose disposal (P = .17). Conclusions: These data show that T can act through putative fast nongenomic pathways to affect adiponectin levels in humans. The early hypogonadal state is characterized by a marked shift in fuel oxidation from lipids toward glucose, which may rely partly on buffering capabilities of adiponectin.

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