scholarly journals Correlation of High-Molecular-Weight Adiponectin and Leptin Concentrations with Anthropometric Parameters and Insulin Sensitivity in Newborns

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Jia Zheng ◽  
Xinhua Xiao ◽  
Qian Zhang ◽  
Lili Mao ◽  
Ming Li ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Insulin Sensitivity ◽  
Cord Blood ◽  
High Molecular Weight ◽  
Linear Regression Analysis ◽  
Anthropometric Measurements ◽  
Multivariate Linear Regression Analysis ◽  
High Molecular Weight Adiponectin ◽  
College Hospital ◽  
Hmw Adiponectin

Objective. High-molecular-weight adiponectin (HMW-adiponectin) and leptin are two important adipokines. The aim of this study was to examine the association between the two adipokines and anthropometric measurements of neonates at birth. Furthermore, we would like to explore whether HMW-adiponectin and leptin correlate with insulin sensitivity in neonates.Methods. Venous cord blood samples were obtained from 266 full-term healthy neonates consecutively born at Peking Union Medical College Hospital. HMW-adiponectin, leptin, blood glucose, and insulin concentrations were measured.Results. HMW-adiponectin and leptin were significantly higher in females compared with males (P=0.031andP=0.000, resp.). Univariate correlation analysis showed that leptin concentrations in cord blood were positively associated with gestational age, birth weight, body length, ponderal index, placenta weight, insulin, and insulin sensitivity (allP<0.001). However, there was no correlation between cord blood HMW-adiponectin levels and foetal anthropometric measurements or foetal insulin sensitivity indicators (allP>0.05). Multivariate linear regression analysis indicated that leptin (B=-0.126,P=0.045) in cord blood was independently associated with insulin sensitivity.Conclusions. Leptin concentrations, but not HMW-adiponectin, were positively associated with foetal anthropometric measurements. Leptin concentrations are significantly associated with foetal insulin sensitivity, and there were no significant correlations between HMW-adiponectin levels and foetal insulin sensitivity.

High-Molecular-Weight Adiponectin and Leptin Levels in Cord Blood Are Associated with Anthropometric Measurements at Birth

2008 ◽  
Vol 70 (5) ◽  
pp. 268-272 ◽  
Author(s):  
Makoto Inoue ◽  
Kazuo Itabashi ◽  
Yuya Nakano ◽  
Yasuko Nakano ◽  
Takashi Tobe
Keyword(s):  
Molecular Weight ◽  
Cord Blood ◽  
High Molecular Weight ◽  
Anthropometric Measurements ◽  
High Molecular Weight Adiponectin

scholarly journals Circulating high-molecular-weight adiponectin is upregulated in preeclampsia and is related to insulin sensitivity and renal function

2008 ◽  
Vol 158 (2) ◽  
pp. 197-201 ◽  
Author(s):  
Mathias Fasshauer ◽  
Theresa Waldeyer ◽  
Jeannette Seeger ◽  
Susanne Schrey ◽  
Thomas Ebert ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Renal Function ◽  
Insulin Sensitivity ◽  
High Molecular Weight ◽  
Active Form ◽  
Biologically Active ◽  
Serum Concentrations ◽  
High Molecular Weight Adiponectin ◽  
Hmw Adiponectin ◽  
Total Adiponectin

ObjectivePreeclampsia (PE) is a serious cardiovascular complication in pregnancy which is associated with an increased future metabolic and cardiovascular risk for mother and newborn. Recently, a paradoxical upregulation of the insulin-sensitizing and anti-atherogenic adipokine adiponectin has been shown in PE. Furthermore, high-molecular-weight (HMW) adiponectin has been suggested as the biologically active form of this adipokine.Design and methodsHMW adiponectin and total adiponectin serum concentrations were quantified by ELISA in PE (n=16) patients and pregnant control women without PE (n=20). Furthermore, HMW adiponectin and total adiponectin were correlated to clinical and biochemical measures of renal function, glucose, and lipid metabolism, as well as inflammation.ResultsMedian maternal HMW adiponectin and total adiponectin levels were significantly and independently upregulated almost twofold in PE when compared with controls. HMW adiponectin and total adiponectin correlated positively with creatinine and negatively with fasting insulin in univariate and multivariate analyses.ConclusionsWe show that maternal HMW adiponectin and total adiponectin serum concentrations are significantly increased in PE and are positively associated with markers of insulin sensitivity and renal dysfunction. Adiponectin might be part of a physiological feedback mechanism improving insulin sensitivity and cardiovascular health in PE.

scholarly journals Associations between Maternal and Fetal Levels of Total Adiponectin, High Molecular Weight Adiponectin, Selected Somatomedins, and Birth Weight of Infants of Smoking and Non-Smoking Mothers

2020 ◽  
Vol 17 (13) ◽  
pp. 4781 ◽  
Author(s):  
Magdalena Chełchowska ◽  
Joanna Gajewska ◽  
Tomasz M. Maciejewski ◽  
Joanna Mazur ◽  
Mariusz Ołtarzewski ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Birth Weight ◽  
Growth Factor ◽  
Cord Blood ◽  
High Molecular Weight ◽  
Umbilical Cord Blood ◽  
High Molecular Weight Adiponectin ◽  
Hmw Adiponectin ◽  
Total Adiponectin ◽  
Igf I

The aim of the study was to determine the relationships between maternal smoking, total adiponectin, high molecular weight adiponectin (HMW adiponectin), selected somatomedins, and the birth weight of newborns. A total of 78 women with a healthy, singleton pregnancy, 41 active smokers and 37 non-smokers, and their offspring were studied. Total and HMW adiponectin, insulin-like growth factor I (IGF-I), and insulin-like growth factor binding protein-1 (IGFBP-1) and 2 (IGFBP-2) were determined in maternal and cord blood by enzyme-link immunosorbent assay. Serum levels of total and HMW adiponectin were lower in smokers compared to the tobacco abstinent in both the mothers (p = 0.013; p = 0.006) and the infants (p = 0.001; p = 0.047). In smoking women and their children, serum concentrations of IGF-I were significantly lower (p = 0.014; p = 0.042), IGFBP-1 significantly higher (p = 0.009; p = 0.039), and IGFBP-2 did not differ from that observed in the non-smoking group. In multivariate analysis performed on the whole group of mothers, the highest impact of serum cotinine and IGFBP-2 levels were indicated for adiponectin and cotinine and the number of cigarettes/day for HMW adiponectin concentration. In correlation analysis estimated separately for smokers and non-smokers, neonatal birth weight was positively associated with total and HMW adiponectin concentrations in umbilical cord blood. Birth weight was also inversely associated with IGFBP-1 and positively correlated with IGF-I levels in maternal serum as well as in cord blood (r = −0.317, p = 0.005; r = −0.294, p = 0.004; r = 0.245, p = 0.031; r = 0.271, p = 0.009, respectively). The present study showed the levels of total and HMW adiponectin in umbilical cord blood may have a significant effect on fetal development. Both IGF-I and IGFBP-1 concentrations also play an essential role in fetal growth, which is an important predictor of birth weight. Cigarette smoking during pregnancy negatively affected adiponectin and the insulin growth factor profile in the serum of women and the cord blood and may be the reason for the lower birth weight of the smokers newborns compared with the nonsmokers offspring.

scholarly journals Linoleic Acid–Rich Oil Supplementation Increases Total and High-Molecular-Weight Adiponectin and Alters Plasma Oxylipins in Postmenopausal Women with Metabolic Syndrome

2020 ◽  
Vol 4 (9) ◽  
Author(s):  
Rachel M Cole ◽  
Sarah Puchala ◽  
Jia-Yu Ke ◽  
Mahmoud Abdel-Rasoul ◽  
Kristin Harlow ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Molecular Weight ◽  
Linoleic Acid ◽  
High Molecular Weight ◽  
Oil Consumption ◽  
Open Label ◽  
High Molecular Weight Adiponectin ◽  
Markers Of Inflammation ◽  
Hmw Adiponectin ◽  
Total Adiponectin

ABSTRACT Background The onset of menopause increases the risk of metabolic syndrome (MetS). Adiponectin is an adipokine associated with insulin sensitivity that is lower in people with MetS. Supplementing diets with linoleic acid (LA)-rich oil increased adiponectin concentrations and improved glucose control in women with type 2 diabetes. The effect of LA on adipokines, especially total and the bioactive form of adiponectin, high-molecular-weight (HMW) adiponectin, in women with MetS is unknown. Objectives The aim of this study was to explore the effect of supplementation of the diet with an oil rich in LA on adipokines in women with MetS. The effect of the LA-rich oil (LA-oil) on oxylipins, key metabolites that may influence inflammation and metabolism, was also explored. Methods In this open-label single-arm pilot study, 18 postmenopausal nondiabetic women with MetS enrolled in a 2-phase study were instructed to consume LA-rich vegetable oil (10 mL/d) as part of their habitual diets. Women consumed an oleic acid–rich oil (OA-oil) for 4 wk followed by an LA-oil for 16 wk. Fasting concentrations of adipokines, fatty acids, oxylipins, and markers of glycemia and inflammation were measured. Results After 4 wk of OA-oil consumption, fasting glucose and total adiponectin concentrations decreased whereas fasting C-reactive protein increased. After 16 wk of LA-oil supplementation total and HMW adiponectin and plasma oxylipins increased. Markers of inflammation and glycemia were unchanged after LA-oil consumption. Conclusions Supplementation with LA-oil increased total and HMW adiponectin concentrations and altered plasma oxylipin profiles. Larger studies are needed to elucidate the links between these changes and MetS. This trial was registered at clinicaltrials.gov as NCT02063165.

scholarly journals Leptin/Adiponectin Ratios Using Either Total Or High-Molecular-Weight Adiponectin as Biomarkers of Systemic Insulin Sensitivity in Normoglycemic Women

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Carolina Bravo ◽  
Luis Rodrigo Cataldo ◽  
José Galgani ◽  
Javier Parada ◽  
José Luis Santos
Keyword(s):  
Molecular Weight ◽  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
High Molecular Weight ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Sensitivity Index ◽  
High Molecular Weight Adiponectin ◽  
Intravenous Glucose ◽  
Negatively Associated

Plasma leptin/adiponectin ratio (LAR) is negatively associated with insulin sensitivity indexes. High-molecular-weight adiponectin (HMWA) was proposed as the most biologically active form of this insulin-sensitizing adipokine. There are no studies assessing the relative merits of leptin/HMWA ratio over LAR as a biomarker of systemic insulin sensitivity. A standard 2-hour oral glucose tolerance test (OGTT; 75 g of glucose) and a short minimal-model intravenous glucose tolerance test (IVGTT; 0.3 g/kg body weight) were performed in 58 Chilean normoglycemic women (age: 27 ± 6.3 years, BMI 23.6 ± 3.2 kg/m2). LAR was negatively associated with HOMA-S (r=−0.49; p<0.0001), Matsuda-ISICOMP (r=−0.54; p<0.0001), and the calculated sensitivity index (CSi) derived from IVGTT (r=−0.38; p=0.007). In comparison to LAR, leptin/HMWA ratio did not increase neither the linear fit (r2) nor the magnitude of association with insulin sensitivity indexes (slope of multiple linear regression). The discriminatory capacity of both ratios to classify insulin-resistant versus insulin-sensitive subjects was similar for HOMA-S (p=0.84), Matsuda-ISICOMP (p=0.43), or CSi (p=0.50). In conclusion, LAR showed consistent negative associations with different systemic insulin sensitivity indexes. The use of HMWA to generate leptin/HMWA ratio did not show any advantage over LAR as a biomarker of systemic insulin sensitivity in normoglycemic women.

Sexual dimorphism of high molecular weight adiponectin in cord blood

2009 ◽  
Vol 70 (3) ◽  
pp. 500-501 ◽  
Author(s):  
Sue Mei Lau ◽  
Tien Ming Hng ◽  
Brad de Vries ◽  
Mark McLean ◽  
N Wah Cheung
Keyword(s):  
Molecular Weight ◽  
Sexual Dimorphism ◽  
Cord Blood ◽  
High Molecular Weight ◽  
High Molecular Weight Adiponectin

High Molecular Weight Adiponectin Correlates with Insulin Sensitivity in Patients with Hepatitis C Genotype 3, But Not Genotype 1 Infection

2005 ◽  
Vol 100 (12) ◽  
pp. 2717-2723 ◽  
Author(s):  
Amy Y-H. Wang ◽  
Ingrid J. Hickman ◽  
Ayanthi A. Richards ◽  
Jonathan P. Whitehead ◽  
Johannes B. Prins ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Hepatitis C ◽  
Insulin Sensitivity ◽  
High Molecular Weight ◽  
Genotype 1 ◽  
Genotype 3 ◽  
High Molecular Weight Adiponectin

Measurement of high-molecular-weight adiponectin is not useful in assessing coronary stenosis

2012 ◽  
Vol 50 (4) ◽  
Author(s):  
Takuya Imatoh ◽  
Motonobu Miyazaki ◽  
Ken Kadowaki ◽  
Shinichi Tanihara ◽  
Chinami Akashi ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Coronary Stenosis ◽  
Active Form ◽  
Surrogate Marker ◽  
Area Under The Curve ◽  
High Molecular Weight Adiponectin ◽  
Cross Sectional ◽  
Hmw Adiponectin ◽  
Total Adiponectin

AbstractIn many studies, high-molecular-weight (HMW) adiponectin has been considered the active form of adiponectin. However, whether HMW adiponectin is a good surrogate marker for coronary artery disease still needs to be elucidated.We conducted a hospital-based cross-sectional study to examine the relationship between total, HMW or non-HMW adiponectin concentrations and coronary stenosis in 83 male patients and 138 male controls.Patients with coronary stenosis had significantly lower total adiponectin concentrations compared with controls. Non-HMW adiponectin concentrations in cases were significantly lower than the controls. However, there were no significant differences between cases and controls in HMW adiponectin concentrations. From the receiver operating characteristic (ROC) analysis, the area under the curve (AUC) for total and non-HMW adiponectin was significantly larger than that for HMW adiponectin concentrations. Of the three models, that for non-HMW adiponectin showed the largest AUC (total adiponectin 0.74, HMW adiponectin 0.54, and non-HMW adiponectin 0.79).Despite associations between total adiponectin levels and coronary stenosis, our data go against any apparent association between HMW adiponectin concentrations and coronary stenosis.

scholarly journals Collagen beta (1-O) galactosyltransferase 1 (GLT25D1) is required for the secretion of high molecular weight adiponectin and affects lipid accumulation

2017 ◽  
Vol 37 (3) ◽  
Author(s):  
Julie A. Webster ◽  
Zhe Yang ◽  
Yu-Hee Kim ◽  
Dorothy Loo ◽  
Rasha M. Mosa ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Lipid Accumulation ◽  
Post Translational Modification ◽  
High Fat ◽  
High Molecular Weight Adiponectin ◽  
Human Embryonic Kidney Cells ◽  
Hmw Adiponectin ◽  
Hek Cells ◽  
Sgbs Cells

Secretion of high molecular weight (HMW) adiponectin is dependent on post-translational modification (PTM) of conserved lysines in the collagenous domain. The present study aims to characterize the enzymes responsible for the PTM of conserved lysines which leads to HMW adiponectin secretion, and to define its significance in relation to obesity. Collagen beta (1-O) galactosyltransferase 1 (GLT25D1) was knocked down in HEK cells modified for the stable expression of adiponectin (adiponectin expressing human embryonic kidney cells, Adipo-HEK) as well as in Simpson Golabi-Behmel-Syndrome (SGBS) adipocytes. Knockdown of GLT25D1 caused a significant decrease in HMW adiponectin in Adipo-HEK cells with no change in total adiponectin. Knockdown in the SGBS cells caused an increase in lipid accumulation yet inhibited adipogenesis. Co-immunoprecipitation with adiponectin and mass spectrometry showed that adiponectin formed a protein complex with lysyl hydroxylase 3 (LH3) and GLT25D1. Transient overexpression of GLT25D1 showed that the intracellular retention of LH3 was dependent on GLT25D1. To determine whether changes in GLT25D1 were significant in obesity, mice were fed a standard chow or high-fat diet (HFD) for 5 weeks. GLT25D1 was significantly decreased in mice fed HFD which coincided with a decrease in HMW adiponectin. We conclude that GLT25D1 regulates HMW adiponectin secretion and lipid accumulation, consistent with changes in mice after high-fat feeding. These results suggest a novel function of GLT25D1 leading to decreased HMW adiponectin secretion in early obesity.

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