EphB1 Is Underexpressed in Poorly Differentiated Colorectal Cancers

Zhen Sheng; Jiandong Wang; Yingchun Dong; Henghui Ma; Hangbo Zhou; Haruhiko Sugimura; Guangming Lu; Xiaojun Zhou

doi:10.1159/000151707

Higher Expression of Epidermal Growth Factor Receptor Is Associated with Extracellular Matrix Metalloprotease Inducer in Colorectal Adenocarcinoma: Tissue Microarray Analysis of Immunostaining Score with Clinicopathological Parameters

Disease Markers ◽

10.1155/2006/890810 ◽

2006 ◽

Vol 22 (5-6) ◽

pp. 309-316 ◽

Cited By ~ 12

Author(s):

Jong-Shiaw Jin ◽

Chi-Ying Wu ◽

Yeh-Feng Lin ◽

Jia-Yi Wang ◽

Cheng-Ping Yu ◽

...

Keyword(s):

Colorectal Adenocarcinoma ◽

Growth Factor Receptor ◽

Clinicopathological Parameters ◽

Colorectal Cancers ◽

Matrix Metalloprotease ◽

Egfr Expression ◽

Poorly Differentiated ◽

Epidermal Growth ◽

Well Differentiated ◽

Colorectal Adenocarcinomas

Aim: Extracellular matrix metalloprotease inducer (EMMPRIN) expression was demonstrated in several cancers, but its expression profile in colorectal cancers remains unclear. Epidermal growth factor receptor (EGFR) was reported to regulate EMMPRIN expression in human epithelial cancers. Our purpose was to determine EMMPRIN expression and its relationship with EGFR in colorectal cancers.Methods: Immunohistochemical analysis of EMMPRIN and EGFR was performed in tissue microarray slides of 90 surgical specimens including 32 well differentiated, 35 moderately differentiated, and 23 poorly differentiated colorectal adenocarcinomas.Results: All colorectal adenocarcinomas showed significant immunohistochemical expression of EMMPRIN. The EMMPRIN scores in poorly differentiated (303 ± 21) and moderately differentiated (326 ± 17) colorectal adenocarcinoma were significantly higher than in well differentiated (166 ± 20) colorectal adenocarcinoma. EGFR expression was mainly on the cell surface of tumor cells and the immunostaining scores of EGFR were significantly associated with the advanced clinical T and N stages. A significantly positive relationship between EMMPRIN and EGFR immunostaining scores was also noted.Conclusions: Increased expression of EMMPRIN and EGFR in colorectal adenocarcinomas is associated with clinicopathological parameters of advanced colorectal adenocarcinoma stages.In addition, the data from this study support the notion that EGFR expression may up-regulate EMMPRIN expression.

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Clinicopathological significance of heterogeneic ezrin expression in poorly differentiated clusters of colorectal cancers

Cancer Science ◽

10.1111/cas.14093 ◽

2019 ◽

Vol 110 (8) ◽

pp. 2667-2675 ◽

Cited By ~ 1

Author(s):

Akane Aikawa ◽

Hideto Fujita ◽

Takeo Kosaka ◽

Hiroshi Minato ◽

Etsuko Kiyokawa

Keyword(s):

Colorectal Cancers ◽

Ezrin Expression ◽

Poorly Differentiated Clusters ◽

Clinicopathological Significance ◽

Poorly Differentiated

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Poorly Differentiated Colorectal Cancers

American Journal of Clinical Pathology ◽

10.1309/ajcp8p2dynkgrbvi ◽

2013 ◽

Vol 140 (3) ◽

pp. 341-347 ◽

Cited By ~ 29

Author(s):

Haitao Xiao ◽

Yong Sik Yoon ◽

Seung-Mo Hong ◽

Seon Ae Roh ◽

Dong-Hyung Cho ◽

...

Keyword(s):

Colorectal Cancers ◽

Poorly Differentiated

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Association between Preoperative Leukocytosis and Pathological Features of Colorectal Cancers

Asian Pacific Journal of Cancer Biology ◽

10.31557/apjcb.2021.6.1.43-47 ◽

2021 ◽

Vol 6 (1) ◽

pp. 43-47

Author(s):

Reza Hajebi ◽

Hadi Ahmadi Amoli ◽

Hossein Zabihi Mahmoudabadi ◽

Ehsan Rahimpour ◽

Khosro Najjari ◽

...

Keyword(s):

Colorectal Cancer ◽

Prognostic Factor ◽

Leukocyte Count ◽

Laboratory Data ◽

Cross Sectional Study ◽

Colorectal Cancers ◽

Sectional Study ◽

Cross Sectional ◽

Poorly Differentiated ◽

The Relationship

Background: Using hematologic profiles including leukocyte count have been considered as prognostic factor for some cancers. We have been assessed the predictive value of leukocytosis before surgery in colorectal cancers.Methods: This cross-sectional study has been conducted on patients with colorectal cancer who underwent surgery from 2017 to 2019 in Sina hospital, Tehran. The patients were divided in two groups based on high and low leukocyte count before surgery. Results: A total of 84 patients were studied with colorectal cancers including 46 males (55.4%) and 37 females (44.6%) with the average age of 55.2 (± 13.63) years. 36.1% of patients had leukocytosis in laboratory data before surgery. There was a significant association between tumor’s grade and the incidence of leukocytosis before surgery (P <0.001). The existence of leukocytosis is highly associated with poorly differentiated tumor. Also, the relationship between the location of the tumor and leukocytosis was seen which the location was distal, the possibility of leukocytosis decreased significantly (P <0.005). Conclusion: Our findings suggest that the location of the tumor and its degree of tumor differentiation are related with leukocytosis. This current study by considering leukocytosis before surgery aimed to use this variable as a prognostic factor in patients with colorectal cancer alongside with other variables.

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PD-L1 Associates with Poorly Differentiated, Microsatellite-Unstable Colorectal Cancers in a Norwegian Population-Based Cohort

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2019.11.269 ◽

2020 ◽

Vol 46 (2) ◽

pp. e108

Author(s):

Martin Watson ◽

Dordi Lea ◽

Einar Gudlaugsson ◽

Hanne R. Hagland ◽

Kjetil Søreide

Keyword(s):

Population Based ◽

Colorectal Cancers ◽

Norwegian Population ◽

Poorly Differentiated

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Motility of leukemic lymphocytes

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100159382 ◽

1990 ◽

Vol 48 (3) ◽

pp. 368-369

Author(s):

Manoj Raje ◽

Karvita B. Ahluwalia

Keyword(s):

Quantitative Data ◽

Laser Doppler Velocimetry ◽

Acute Lymphocytic Leukemia ◽

Lymphocytic Leukemia ◽

Cellular Space ◽

Differentiated Cells ◽

Poorly Differentiated ◽

Solid Tissues ◽

Well Differentiated ◽

Reduced Mobility

In Acute Lymphocytic Leukemia motility of lymphocytes is associated with dissemination of malignancy and establishment of metastatic foci. Normal and leukemic lymphocytes in circulation reach solid tissues where due to in adequate perfusion some cells get trapped among tissue spaces. Although normal lymphocytes reenter into circulation leukemic lymphocytes are thought to remain entrapped owing to reduced mobility and form secondary metastasis. Cell surface, transmembrane interactions, cytoskeleton and level of cell differentiation are implicated in lymphocyte mobility. An attempt has been made to correlate ultrastructural information with quantitative data obtained by Laser Doppler Velocimetry (LDV). TEM of normal & leukemic lymphocytes revealed heterogeneity in cell populations ranging from well differentiated (Fig. 1) to poorly differentiated cells (Fig. 2). Unlike other cells, surface extensions in differentiated lymphocytes appear to originate by extrusion of large vesicles in to extra cellular space (Fig. 3). This results in persistent unevenness on lymphocyte surface which occurs due to a phenomenon different from that producing surface extensions in other cells.

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