scholarly journals Clinicopathological significance of heterogeneic ezrin expression in poorly differentiated clusters of colorectal cancers

2019 ◽  
Vol 110 (8) ◽  
pp. 2667-2675 ◽  
Author(s):  
Akane Aikawa ◽  
Hideto Fujita ◽  
Takeo Kosaka ◽  
Hiroshi Minato ◽  
Etsuko Kiyokawa
Keyword(s):  
Colorectal Cancers ◽  
Ezrin Expression ◽  
Poorly Differentiated Clusters ◽  
Clinicopathological Significance ◽  
Poorly Differentiated

EphB1 Is Underexpressed in Poorly Differentiated Colorectal Cancers

Pathobiology ◽  
2008 ◽  
Vol 75 (5) ◽  
pp. 274-280 ◽  
Author(s):  
Zhen Sheng ◽  
Jiandong Wang ◽  
Yingchun Dong ◽  
Henghui Ma ◽  
Hangbo Zhou ◽  
...  
Keyword(s):  
Colorectal Cancers ◽  
Poorly Differentiated

scholarly journals Separation of Low- Versus High-grade Crohn’s Disease-associated Small Bowel Carcinomas is Improved by Invasive Front Prognostic Marker Analysis

2019 ◽  
Vol 14 (3) ◽  
pp. 295-302 ◽  
Author(s):  
Giovanni Arpa ◽  
Federica Grillo ◽  
Paolo Giuffrida ◽  
Gabriella Nesi ◽  
Catherine Klersy ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Stage I ◽  
Low Grade ◽  
Invasive Front ◽  
Poorly Differentiated Clusters ◽  
Small Bowel Carcinoma ◽  
Poorly Differentiated ◽  
Tumour Budding

Abstract Background and Aims Crohn’s disease-associated small bowel carcinoma is a rare event, usually reported to have a severe prognosis. However, in previous investigations we have found a minority of cases displaying a relatively favourable behaviour, thus outlining the need to improve the histopathological prediction of Crohn’s disease-associated small bowel carcinoma prognosis. Methods As in recent studies on colorectal cancer, a substantial improvement in prognostic evaluations has been provided by the histological analysis of the tumour invasive front; we therefore systematically analysed the tumour budding and poorly differentiated clusters in the invasive front of 47 Crohn’s disease-associated small bowel carcinomas collected through the Small Bowel Cancer Italian Consortium. Results Both tumour budding and poorly differentiated cluster analyses proved highly effective in prognostic evaluation of Crohn’s disease-associated small bowel carcinomas. In addition, they retained prognostic value when combined with two other parameters, i.e. glandular histology and stage I/II, both known to predict a relatively favourable small bowel carcinoma behaviour. In particular, association of tumour budding and poorly differentiated clusters in a combined invasive front score allowed identification of a minor subset of cancers [12/47, 25%] characterised by combined invasive front low grade coupled with a glandular histology and a low stage [I or II] and showing no cancer-related death during a median follow-up of 73.5 months. Conclusions The improved distinction of lower- from higher-grade Crohn’s disease-associated small bowel carcinomas provided by invasive front analysis should be of potential help in choosing appropriate therapy for these rare and frequently ominous neoplasms.

scholarly journals Higher Expression of Epidermal Growth Factor Receptor Is Associated with Extracellular Matrix Metalloprotease Inducer in Colorectal Adenocarcinoma: Tissue Microarray Analysis of Immunostaining Score with Clinicopathological Parameters

2006 ◽  
Vol 22 (5-6) ◽  
pp. 309-316 ◽  
Author(s):  
Jong-Shiaw Jin ◽  
Chi-Ying Wu ◽  
Yeh-Feng Lin ◽  
Jia-Yi Wang ◽  
Cheng-Ping Yu ◽  
...  
Keyword(s):  
Colorectal Adenocarcinoma ◽  
Growth Factor Receptor ◽  
Clinicopathological Parameters ◽  
Colorectal Cancers ◽  
Matrix Metalloprotease ◽  
Egfr Expression ◽  
Poorly Differentiated ◽  
Epidermal Growth ◽  
Well Differentiated ◽  
Colorectal Adenocarcinomas

Aim: Extracellular matrix metalloprotease inducer (EMMPRIN) expression was demonstrated in several cancers, but its expression profile in colorectal cancers remains unclear. Epidermal growth factor receptor (EGFR) was reported to regulate EMMPRIN expression in human epithelial cancers. Our purpose was to determine EMMPRIN expression and its relationship with EGFR in colorectal cancers.Methods: Immunohistochemical analysis of EMMPRIN and EGFR was performed in tissue microarray slides of 90 surgical specimens including 32 well differentiated, 35 moderately differentiated, and 23 poorly differentiated colorectal adenocarcinomas.Results: All colorectal adenocarcinomas showed significant immunohistochemical expression of EMMPRIN. The EMMPRIN scores in poorly differentiated (303 ± 21) and moderately differentiated (326 ± 17) colorectal adenocarcinoma were significantly higher than in well differentiated (166 ± 20) colorectal adenocarcinoma. EGFR expression was mainly on the cell surface of tumor cells and the immunostaining scores of EGFR were significantly associated with the advanced clinical T and N stages. A significantly positive relationship between EMMPRIN and EGFR immunostaining scores was also noted.Conclusions: Increased expression of EMMPRIN and EGFR in colorectal adenocarcinomas is associated with clinicopathological parameters of advanced colorectal adenocarcinoma stages.In addition, the data from this study support the notion that EGFR expression may up-regulate EMMPRIN expression.

Poorly Differentiated Clusters: Clinical Impact in Colorectal Cancer

2017 ◽  
Vol 16 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Valeria Barresi ◽  
Luca Reggiani Bonetti ◽  
Antonio Ieni ◽  
Rosario Alberto Caruso ◽  
Giovanni Tuccari
Keyword(s):  
Colorectal Cancer ◽  
Clinical Impact ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated

Sa1943 Histopathologic Grading Using Poorly-Differentiated Clusters Predicts Outcome in Colorectal Carcinoma

2014 ◽  
Vol 146 (5) ◽  
pp. S-335
Author(s):  
Hector H. Li-Chang ◽  
Bojana Mitrovic ◽  
Kelly Handley ◽  
Richard Gray ◽  
Naziheh Assarzadegan ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated

scholarly journals Comment on Jun, S.Y.; et al. “Tumor Budding and Poorly Differentiated Clusters in Small Intestinal Adenocarcinoma” Cancers 2020, 12, 2199

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2982 ◽  
Author(s):  
Paolo Giuffrida ◽  
Giovanni Arpa ◽  
Alessandro Vanoli ◽  
Antonio Di Sabatino
Keyword(s):  
Tumor Budding ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated ◽  
Small Intestinal ◽  
Small Intestinal Adenocarcinoma

We read with interest the paper by Jun S [...]

scholarly journals Tumour budding, poorly differentiated clusters, and T-cell response in colorectal cancer

EBioMedicine ◽  
2020 ◽  
Vol 57 ◽  
pp. 102860 ◽  
Author(s):  
Kenji Fujiyoshi ◽  
Juha P. Väyrynen ◽  
Jennifer Borowsky ◽  
David J. Papke ◽  
Kota Arima ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
T Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated ◽  
Tumour Budding
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