Surface Features of Epithelium of the Seminal Vesicle in Young Adult and Old Guinea Pigs and after Castration

1983 ◽  
Vol 116 (3) ◽  
pp. 257-264 ◽  
Author(s):  
Y.C. Wong
Keyword(s):  
Young Adult ◽  
Seminal Vesicle ◽  
Guinea Pigs ◽  
Surface Features

AN INCREASED RATE OF CHOLESTEROL BIOSYNTHESIS WITH MICROSOME FRACTIONS OF LIVER FROM KETOTIC GUINEA PIGS

1962 ◽  
Vol 40 (1) ◽  
pp. 1749-1762 ◽  
Author(s):  
F. Sauer
Keyword(s):  
Young Adult ◽  
Guinea Pigs ◽  
Cholesterol Synthesis ◽  
Cholesterol Biosynthesis ◽  
Maximum Activity ◽  
Sterol Synthesis ◽  
Differential Centrifugation ◽  
Microsome Fraction ◽  
Liver Homogenates ◽  
Increased Activity

Cholesterol synthesis was studied in liver fractions obtained by differential centrifugation from young, adult, and ketotic guinea pigs. Both 10,000 × g and 105,000 × g sediment was required for maximum activity. Incubations were carried out in the presence of appropriate liver fractions from young guinea pigs in order to overcome the low rates of cholesterol synthesis in liver homogenates from adult guinea pigs. Microsome fractions from ketotic hyperlipemic guinea pigs actively promoted sterol synthesis when incubated with mitochondria plus supernatant from young guinea pigs, while microsome fractions from adult controls (fed or starved) decreased the rate of sterol synthesis in the same incubation system. The results of this investigation indicate that microsomes from hyperlipemic ketotic guinea pigs do not have a block in cholesterol synthesis characteristic of microsomes from starved animals, and that this microsome fraction has increased activity of HMG-CoA2reductase, one of the key enzymes of cholesterol synthesis.

On the different lipolytic capability of diverse organs from young adult guinea pigs. A chromatographic study

2010 ◽  
Vol 23 (4) ◽  
pp. 277-281
Author(s):  
Fatma Helmy ◽  
Sanese White ◽  
Sohrab Amiri ◽  
Rohina Amiri ◽  
Aminat Saliu
Keyword(s):  
Young Adult ◽  
Guinea Pigs ◽  
Chromatographic Study

scholarly journals Sex-specific Alterations in Hepatic Cholesterol Metabolism in Young Uteroplacental Insufficiency-induced Low Birth Weight Adult Guinea Pig Offspring

2020 ◽  
Author(s):  
Ousseynou Sarr ◽  
Katherine E. Mathers ◽  
Christina Vanderboor ◽  
Aditya Devgan ◽  
Daniel B. Hardy ◽  
...  
Keyword(s):  
Risk Factor ◽  
Birth Weight ◽  
Young Adult ◽  
Low Birth Weight ◽  
Guinea Pig ◽  
Guinea Pigs ◽  
Cholesterol Metabolism ◽  
Later Life ◽  
Male Offspring ◽  
Hepatic Cholesterol

AbstractBackgroundIntrauterine growth restriction (IUGR) and low birth weight (LBW) have been widely reported as an independent risk factor for hypercholesterolemia and increased hepatic cholesterol underlying liver dysfunction in adulthood. However, the specific impact of uteroplacental insufficiency (UPI), a leading cause of LBW in developed world, on hepatic cholesterol metabolism in later life, is ill defined and is clinically relevant in understanding later life liver metabolic health trajectories.MethodsHepatic cholesterol metabolism pathways were studied in uterine artery ablation-induced LBW and normal birth weight (NBW) male and female guinea pig offspring at postnatal day 150.ResultsHepatic free and total cholesterol were increased in LBW versus NBW males. Transcriptome analysis of LBW versus NBW livers revealed that “Cholesterol metabolism” was an enriched pathway in LBW males but not females. Microsomal triglyceride transfer protein and cytochrome P450 7A1 protein, involved in hepatic cholesterol efflux and catabolism, respectively, and catalase activity were decreased in LBW male livers. Superoxide dismutase activity was reduced in LBW males but increased in LBW females.ConclusionsUPI environment is associated with a later life programed hepatic cholesterol accumulation via impaired cholesterol elimination, in a sex-specific manner. These programmed alterations could underlie later life cholesterol-induced hepatic lipotoxicity in LBW male offspring.Impact StatementLow birth weight (LBW) is a risk factor for adult hypercholesterolemia and increased hepatic cholesterol.Uteroplacental insufficiency (UPI) resulting in LBW increased hepatic cholesterol content, altered hepatic expression of cholesterol metabolism-related genes in young adult guinea pigs.UPI-induced LBW was also associated with markers of a compromised hepatic cholesterol elimination process and failing antioxidant system in young adult guinea pigs.These changes, at the current age studied, were sex-specific, only being observed in LBW males and not LBW females.These programmed alterations could lead to further hepatic damage and greater predisposition to liver diseases in UPI-induced LBW male offspring as they age.

AN INCREASED RATE OF CHOLESTEROL BIOSYNTHESIS WITH MICROSOME FRACTIONS OF LIVER FROM KETOTIC GUINEA PIGS

1962 ◽  
Vol 40 (12) ◽  
pp. 1749-1762 ◽  
Author(s):  
F. Sauer
Keyword(s):  
Young Adult ◽  
Guinea Pigs ◽  
Cholesterol Synthesis ◽  
Cholesterol Biosynthesis ◽  
Maximum Activity ◽  
Sterol Synthesis ◽  
Differential Centrifugation ◽  
Microsome Fraction ◽  
Liver Homogenates ◽  
Increased Activity

Cholesterol synthesis was studied in liver fractions obtained by differential centrifugation from young, adult, and ketotic guinea pigs. Both 10,000 × g and 105,000 × g sediment was required for maximum activity. Incubations were carried out in the presence of appropriate liver fractions from young guinea pigs in order to overcome the low rates of cholesterol synthesis in liver homogenates from adult guinea pigs. Microsome fractions from ketotic hyperlipemic guinea pigs actively promoted sterol synthesis when incubated with mitochondria plus supernatant from young guinea pigs, while microsome fractions from adult controls (fed or starved) decreased the rate of sterol synthesis in the same incubation system. The results of this investigation indicate that microsomes from hyperlipemic ketotic guinea pigs do not have a block in cholesterol synthesis characteristic of microsomes from starved animals, and that this microsome fraction has increased activity of HMG-CoA2reductase, one of the key enzymes of cholesterol synthesis.

Effects of intravenous steroids on seminal vesicle contractions of castrated rats

1960 ◽  
Vol 198 (4) ◽  
pp. 754-756 ◽  
Author(s):  
Jerome A. Grunt ◽  
Joseph E. Walker ◽  
James T. Higgins
Keyword(s):  
Young Adult ◽  
Seminal Vesicle ◽  
Sodium Succinate ◽  
Water Soluble ◽  
Male Rats ◽  
Methyl Prednisolone ◽  
Rhythmic Contractions ◽  
Intravenous Steroids

Young adult castrated male rats were used in a study of the effects of four intravenous steroids on seminal vesicle contractions. One lobe of each animal's seminal vesicle was exteriorized and recordings of the rhythmic contractions were made with a muscle lever attached to a kymograph. Following two periods of control recordings, each of the animals was injected intravenously with either 300 µg water soluble testosterone, 200 µg water-soluble estrogen (Premarin), 300 µg hydrocortisone hemisuccinate or 300 µg methyl prednisolone sodium succinate. The administration of androgen was followed by an inhibition of the frequency of contraction in 8 of the 11 animals. Four of the sixteen animals injected with intravenous estrogen showed a decrease in frequency of contractions. There was no seminal vesicle slowing following administration of either corticoid. An intravenous technique here described, allowed the administration of steroid at any time during the experiment without interrupting the preparation.

The Geosciences Applied to Lunar Exploration

1962 ◽  
Vol 14 ◽  
pp. 169-257 ◽  
Author(s):  
J. Green
Keyword(s):  
Lunar Surface ◽  
Probable Mechanism ◽  
Point Of View ◽  
Lunar Exploration ◽  
Geological Model ◽  
Apply Geophysics ◽  
Surface Features ◽  
The Impact

The term geo-sciences has been used here to include the disciplines geology, geophysics and geochemistry. However, in order to apply geophysics and geochemistry effectively one must begin with a geological model. Therefore, the science of geology should be used as the basis for lunar exploration. From an astronomical point of view, a lunar terrain heavily impacted with meteors appears the more reasonable; although from a geological standpoint, volcanism seems the more probable mechanism. A surface liberally marked with volcanic features has been advocated by such geologists as Bülow, Dana, Suess, von Wolff, Shaler, Spurr, and Kuno. In this paper, both the impact and volcanic hypotheses are considered in the application of the geo-sciences to manned lunar exploration. However, more emphasis is placed on the volcanic, or more correctly the defluidization, hypothesis to account for lunar surface features.

Investigation of the relaxant effects of propofol on ovalbumin-induced asthma in guinea pigs

2006 ◽  
pp. 1
Author(s):  
I. Bagcivan ◽  
O. Cevit ◽  
M. K. Yildirim ◽  
S. Gursoy ◽  
S. Yildirim ◽  
...  
Keyword(s):  
Guinea Pigs
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