Cyto- and Myeloarchitectural Studies on the Lateral Tuberal Nucleus in Simian Callithricidae and Prosimiae

1982 ◽  
Vol 114 (2) ◽  
pp. 155-164 ◽  
Author(s):  
Masako Fujii
Keyword(s):  
Tuberal Nucleus

Atrophy of the Hypothalamic Lateral Tuberal Nucleus in Huntingtonʼs Disease

1990 ◽  
Vol 49 (4) ◽  
pp. 371-382 ◽  
Author(s):  
H P H Kremer ◽  
R A C Roos ◽  
G Dingjan ◽  
G Th A.M. Bots ◽  
E Maran
Keyword(s):  
Tuberal Nucleus

scholarly journals The hypothalamic lateral tuberal nucleus in Alzheimer's disease

1991 ◽  
Vol 29 (3) ◽  
pp. 279-284 ◽  
Author(s):  
Berry Kremer ◽  
Dick Swaab ◽  
Gerard Bots ◽  
Bart Fisser ◽  
Rivka Ravid ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Tuberal Nucleus

scholarly journals Endogenous Melanocortin Antagonist in Fish: Structure, Brain Mapping, and Regulation by Fasting of the Goldfish Agouti-Related Protein Gene

Endocrinology ◽  
2003 ◽  
Vol 144 (10) ◽  
pp. 4552-4561 ◽  
Author(s):  
José Miguel Cerdá-Reverter ◽  
Richard Ector Peter
Keyword(s):  
Energy Balance ◽  
Food Intake ◽  
Brain Mapping ◽  
Arcuate Nucleus ◽  
Mrna Levels ◽  
Central Administration ◽  
Related Protein ◽  
Melanocortin Peptides ◽  
Agouti Related Protein ◽  
Tuberal Nucleus

Agouti-related protein (AGRP) is a naturally occurring antagonist of melanocortin. In mammals, central AGRP expression is restricted to the arcuate nucleus in which it plays a key role in the control of energy balance by antagonizing melanocortin effects at melanocortin 4 receptors. In goldfish, melanocortin 4 receptor is profusely expressed within the main brain areas for the control of energy balance, and central administration of agonist or antagonist analogs inhibits or stimulates food intake, respectively. Here we demonstrate that the goldfish genome has a homologous gene to mammalian AGRP. Detailed brain mapping by in situ hybridization shows that AGRP is exclusively expressed in the ventrobasal hypothalamic lateral tuberal nucleus, the teleostean homolog of the arcuate nucleus. Fasting up-regulates its mRNA levels in the lateral tuberal nucleus. In the periphery, AGRP is expressed in several tissues including ovary, muscle, and ventral skin, suggesting that AGRP might regulate peripheral actions of melanocortin peptides. The results provide the first evidence for an endogenous melanocortin antagonist in nontetrapod species and suggest that hypothalamic overexpression during fasting might regulate the inhibitory effects of melanocortin peptides on food intake in goldfish.

scholarly journals SAT-409 A Novel Population of Kisspeptin Neurons in the Medial Tuberal Nucleus of the Hypothalamus in Mice

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Shannon Stephens ◽  
Reanna Liaw ◽  
Noelia Di Giorgio ◽  
Victoria Lux-Lantos ◽  
Alexander Kauffman
Keyword(s):  
Tuberal Nucleus

Regulation of feeding by somatostatin neurons in the tuberal nucleus

Science ◽  
2018 ◽  
Vol 361 (6397) ◽  
pp. 76-81 ◽  
Author(s):  
Sarah Xinwei Luo ◽  
Ju Huang ◽  
Qin Li ◽  
Hasan Mohammad ◽  
Chun-Yao Lee ◽  
...  
Keyword(s):  
Body Weight Gain ◽  
Stria Terminalis ◽  
Unknown Mechanism ◽  
Bed Nucleus ◽  
Reduced Body ◽  
Feeding Regulation ◽  
Cytological Changes ◽  
Somatostatin Neurons ◽  
New Perspective ◽  
Tuberal Nucleus

The tuberal nucleus (TN) is a surprisingly understudied brain region. We found that somatostatin (SST) neurons in the TN, which is known to exhibit pathological or cytological changes in human neurodegenerative diseases, play a crucial role in regulating feeding in mice. GABAergic tuberal SST (TNSST) neurons were activated by hunger and by the hunger hormone, ghrelin. Activation of TNSST neurons promoted feeding, whereas inhibition reduced it via projections to the paraventricular nucleus and bed nucleus of the stria terminalis. Ablation of TNSST neurons reduced body weight gain and food intake. These findings reveal a previously unknown mechanism of feeding regulation that operates through orexigenic TNSST neurons, providing a new perspective for understanding appetite changes.

ALZHEIMER-RELATED CYTOSKELETAL CHANGES IN THE HYPOTHALAMIC LATERAL TUBERAL NUCLEUS

1995 ◽  
Vol 54 (3) ◽  
pp. 430
Author(s):  
E. Braak ◽  
H. Braak ◽  
C. Schultz ◽  
D. Yilmazer ◽  
J. W. Goethe
Keyword(s):  
Tuberal Nucleus
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