Regulation of feeding by somatostatin neurons in the tuberal nucleus

Science ◽  
2018 ◽  
Vol 361 (6397) ◽  
pp. 76-81 ◽  
Author(s):  
Sarah Xinwei Luo ◽  
Ju Huang ◽  
Qin Li ◽  
Hasan Mohammad ◽  
Chun-Yao Lee ◽  
...  
Keyword(s):  
Body Weight Gain ◽  
Stria Terminalis ◽  
Unknown Mechanism ◽  
Bed Nucleus ◽  
Reduced Body ◽  
Feeding Regulation ◽  
Cytological Changes ◽  
Somatostatin Neurons ◽  
New Perspective ◽  
Tuberal Nucleus

The tuberal nucleus (TN) is a surprisingly understudied brain region. We found that somatostatin (SST) neurons in the TN, which is known to exhibit pathological or cytological changes in human neurodegenerative diseases, play a crucial role in regulating feeding in mice. GABAergic tuberal SST (TNSST) neurons were activated by hunger and by the hunger hormone, ghrelin. Activation of TNSST neurons promoted feeding, whereas inhibition reduced it via projections to the paraventricular nucleus and bed nucleus of the stria terminalis. Ablation of TNSST neurons reduced body weight gain and food intake. These findings reveal a previously unknown mechanism of feeding regulation that operates through orexigenic TNSST neurons, providing a new perspective for understanding appetite changes.

scholarly journals The Anteroventral Bed Nucleus of the Stria Terminalis Differentially Regulates Hypothalamic-Pituitary-Adrenocortical Axis Responses to Acute and Chronic Stress

Endocrinology ◽  
2007 ◽  
Vol 149 (2) ◽  
pp. 818-826 ◽  
Author(s):  
Dennis C. Choi ◽  
Nathan K. Evanson ◽  
Amy R. Furay ◽  
Yvonne M. Ulrich-Lai ◽  
Michelle M. Ostrander ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Hpa Axis ◽  
Paraventricular Nucleus ◽  
Restraint Stress ◽  
Body Weight Gain ◽  
Stria Terminalis ◽  
Thymic Involution ◽  
Bed Nucleus ◽  
Acute And Chronic Stress

The anteroventral region of the bed nucleus of the stria terminalis (BST) stimulates hypothalamic-pituitary-adrenocortical (HPA) axis responses to acute stress. However, the role of the anterior BST nuclei in chronic drive of the HPA axis has yet to be established. Therefore, this study tests the role of the anteroventral BST in physiological responses to chronic drive, using a chronic variable stress (CVS) model. Male Sprague-Dawley rats received either bilateral ibotenate lesions, targeting the anteroventral BST, or vehicle injection into the same region. Half of the lesion and control rats were exposed to a 14-d CVS paradigm consisting of twice-daily exposure to unpredictable, alternating stressors. The remaining rats were nonhandled control animals that remained in home cages. On the morning after the end of CVS exposure, all rats were exposed to a novel restraint stress challenge. CVS induced attenuated body weight gain, adrenal hypertrophy, thymic involution, and enhanced CRH mRNA in hypophysiotrophic neurons of the hypothalamic paraventricular nucleus, none of which were affected by anteroventral BST lesions. In the absence of CVS, lesions attenuated the plasma corticosterone and paraventricular nucleus c-fos mRNA responses to the acute restraint stress. In contrast, lesions of the anteroventral BST elevated plasma ACTH and corticosterone responses to novel restraint in the rats previously exposed to CVS. These data suggest that the anterior BST plays very different roles in integrating acute stimulation and chronic drive of the HPA axis, perhaps mediated by chronic stress-induced recruitment of distinct BST cell groups or functional reorganization of stress-integrative circuits.

scholarly journals Somatostatin neurons of the bed nucleus of stria terminalis enhance associative fear memory consolidation in mice

2021 ◽  
pp. JN-RM-1944-20
Author(s):  
Biborka Bruzsik ◽  
Laszlo Biro ◽  
Dora Zelena ◽  
Eszter Sipos ◽  
Huba Szebik ◽  
...  
Keyword(s):  
Memory Consolidation ◽  
Fear Memory ◽  
Stria Terminalis ◽  
Bed Nucleus ◽  
Somatostatin Neurons

scholarly journals Somatostatin neurons of the bed nucleus of stria terminalis enhance associative fear memory consolidation in mice

2020 ◽  
Author(s):  
Biborka Bruzsik ◽  
Laszlo Biro ◽  
Dora Zelena ◽  
Eszter Sipos ◽  
Huba Szebik ◽  
...  
Keyword(s):  
Memory Consolidation ◽  
Fear Memory ◽  
Fear Learning ◽  
Stria Terminalis ◽  
Memory Strength ◽  
Bed Nucleus ◽  
Consolidation Phase ◽  
Somatostatin Neurons ◽  
Core Symptoms

AbstractExcessive fear learning and extinction-resistant fear memories are core symptoms of anxiety and trauma-related disorders. Despite significant evidence from clinical studies reporting hyperactivity of the bed nucleus of stria terminalis (BNST) under these conditions, the role of BNST in fear learning and expression is still not clarified. Here, we tested how BNST modulates fear learning in mice using a chemogenetic approach. Activation of GABAergic neurons of BNST during fear acquisition, more specifically the consolidation phase, resulted in enhanced cued fear recall. Importantly, BNST activation had no acute impact on fear expression during conditioning or recalls, but it enhanced cued fear recall subsequently, potentially via altered activity of downstream regions as indicated by c-Fos. Enhanced fear memory consolidation could be replicated by selectively activating somatostatin neurons (but not corticotropin releasing factor neurons), suggesting significant modulation of fear memory strength by specific circuits of BNST.

Author response for "Projections from the Dorsomedial Division of the Bed Nucleus of the Stria Terminalis to Hypothalamic Nuclei in the Mouse"

2020 ◽  
Author(s):  
Marie Barbier ◽  
J. Antonio González ◽  
Christophe Houdayer ◽  
Denis Burdakov ◽  
Pierre‐Yves Risold ◽  
...  
Keyword(s):  
Author Response ◽  
Stria Terminalis ◽  
Bed Nucleus ◽  
Hypothalamic Nuclei
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