Comparative Study of Gastrointestinal Tract and Liver Toxicity of Ferrous Sulfate, Iron Amino Chelate and Iron Polymaltose Complex in Normal Rats

Pharmacology ◽  
2008 ◽  
Vol 82 (2) ◽  
pp. 127-137 ◽  
Author(s):  
Jorge E. Toblli ◽  
Gabriel Cao ◽  
Leda Olivieri ◽  
Margarita Angerosa
Author(s):  
Jose Remes-Troche ◽  
Josefa María García Montes ◽  
Federico Roesch-Dietlen ◽  
Juan Manuel Herrerías-Gutiérrez ◽  
Victoria Alejandra Jiménez-García ◽  
...  

2014 ◽  
Vol 37 (1) ◽  
pp. 75-81
Author(s):  
Dimitrichka Dimitrova ◽  
Anna Arnaudova-Matey ◽  
Petar Dilov ◽  
Geno Angelov ◽  
Tandju Mehmedov ◽  
...  

Abstract The pharmacokinetics of ferrous methionate and ferrous sulphate was investigated in broiler chickens after intravenous injection and crop intubation. The iron compounds were injected intravenously in v. brachialis. After a 20-day “wash-out” period the ferrous methionate and ferrous sulphate were administered again by an elastic silicone tube into the crop. The serum concentrations of the iron were determined using a bioanalyser. Two pharmacokinetic approaches were used - compartmental and non-compartmental analysis. After i.v. injection we found statistically significantly longer and better distribution of the iron contained in the ferrous methionate compared to the ferrous sulphate. The АUC0→∞ was statistically significantly higher in the ferrous methionate. In the alimentary tract of broiler chickens, ferrous methionate was absorbed more rapidly than ferrous sulfate. It was also distributed at a higher volume as compared to the ferrous sulfate


2016 ◽  
Vol 39 (2) ◽  
pp. 225-231 ◽  
Author(s):  
Piret Hussar ◽  
Martin Kärner ◽  
Tõnu Järveots ◽  
Lazo Pendovski ◽  
Ilmars Duritis ◽  
...  

AbstractThe knowledge about transport of sugars in animals and birds gastrointestinal tract is very important for science as carbohydrates are the main energy source of food. Since until now there is few information about the localization of glucose transporters - integral membrane proteins that mediate the transport of glucose and related substances across the cellular membranes - in birds gastrointestinal tract, the aim of the present study was to localize glucose transporters-2 and -5 (GLUT-2 and -5) in three parts of the ostriches gastrointestinal tract – proventriculus, duodenum and ileum - comparatively in ostrich chicken in their early ontogenesis period. Material from the superficial gland zone of the proventriculus, duodenum and terminal zone of the ileum were collected from eight female ostriches (Struthio camelus var. Domesticus): two chickens after hatching, three 7 and three 30-days old ostriches. The material was fixed with 10% formalin, embedded into paraffin, slices 7 μm thick were cut followed by immunohistochemical staining with polyclonal primary antibodies Rabbit anti-GLUT-2 and Rabbit anti-GLUT-5, carried out according to the manufacturers guidelines (IHC kit, Abcam, UK). The results showed that the staining for both antibodies was weaker in all parts of the gastrointestinal tract of ostriches after hatching compared to 7 and 30 days old ostriches showing that the gastrointestinal tract of ostriches immediately after hatching is not entirely capable of transportation of carbohydrates. The results of our study may indicate the possibility of a close relationship between feeding and the ability to transport sugars in the gastrointestinal tract.


2020 ◽  
Vol 105 (1) ◽  
pp. 313-325
Author(s):  
Yixiao Zhu ◽  
Zhisheng Wang ◽  
Rui Hu ◽  
Xueying Wang ◽  
Fengpeng Li ◽  
...  

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