Comparative study of the biotransformation of bepridil analogs in isolated liver cells from one rat. Relationships between structure and in vitro liver toxicity

1996 ◽  
Vol 21 (4) ◽  
pp. 315-325 ◽  
Author(s):  
E. Damatte ◽  
M. J. Galmier ◽  
C. Lartigue-Mattei ◽  
J. F. Pognat ◽  
N. Busch ◽  
...  
Keyword(s):  
Comparative Study ◽  
Liver Toxicity ◽  
Liver Cells ◽  
Isolated Liver Cells ◽  
Isolated Liver

scholarly journals Leucine and tryptophan metabolism in rats

1985 ◽  
Vol 225 (2) ◽  
pp. 277-281 ◽  
Author(s):  
M Salter ◽  
D A Bender ◽  
C I Pogson
Keyword(s):  
Amino Acid ◽  
Membrane Transport ◽  
Liver Cells ◽  
Tryptophan Metabolism ◽  
Extreme Conditions ◽  
Isolated Liver Cells ◽  
Tryptophan Oxidation ◽  
Isolated Liver ◽  
Tryptophan Uptake

The rate of tryptophan metabolism in isolated liver cells from animals fed on a high-leucine diet was greater than for cells from control animals. Leucine inhibited tryptophan metabolism and tryptophan uptake in isolated liver cells, probably by competing for membrane transport. Leucine had no effect on tryptophan 2,3-dioxygenase in vitro. 4-Methyl-2-oxovalerate increased tryptophan oxidation in incubations containing albumin, by displacing bound tryptophan and increasing the availability of the amino acid to the cell. The results suggest that, under extreme conditions, when the availability of tryptophan is low, leucine may be pellagragenic.

Pathobiology and experimental therapeutics in hepatocellular cholestasis: lessons from the hepatocyte couplet model

2002 ◽  
Vol 102 (6) ◽  
pp. 603-614 ◽  
Author(s):  
Piotr MILKIEWICZ ◽  
Marcelo G. ROMA ◽  
Elwyn ELIAS ◽  
Roger COLEMAN
Keyword(s):  
Experimental Data ◽  
Intrahepatic Cholestasis ◽  
Liver Cells ◽  
Experimental Models ◽  
Experimental Therapeutics ◽  
Bile Formation ◽  
Isolated Liver Cells ◽  
Hepatocellular Cholestasis ◽  
Isolated Liver

Preparations of isolated liver cells, either freshly prepared or in culture, have been available for many years; however, because they lack the polarization of the cell in the tissue, their application to the study of processes involved in bile formation has been very limited. The hepatocyte couplet model offers a unique opportunity to study in vitro the intracellular processes involved: not only the physiology and pathophysiology of bile formation, but also the corresponding structural and molecular disturbances underlying different experimental models of cholestasis. In this review we describe the experimental data generated from this model in our laboratory over a period of years, including application of hepatocyte couplets to the study of cytoskeletal changes within the hepatocyte and mechanisms of hepatoprotection in experimentally induced, clinically relevant models of intrahepatic cholestasis.

In vitro metabolism of vitamin D3 by isolated liver cells

1977 ◽  
Vol 15 (3) ◽  
pp. 213-217 ◽  
Author(s):  
Joseph F. Reitano ◽  
Martha A. Reed ◽  
Patricia L. Rostron ◽  
Charles M. Intenzo ◽  
David M. Capuzzi
Keyword(s):  
Vitamin D3 ◽  
Liver Cells ◽  
In Vitro Metabolism ◽  
Isolated Liver Cells ◽  
Isolated Liver

scholarly journals Arachidonic acid synthesis studied in isolated liver cells

FEBS Letters ◽  
1981 ◽  
Vol 133 (2) ◽  
pp. 201-204 ◽  
Author(s):  
B.O. Christophersen ◽  
Jon Norseth
Keyword(s):  
Arachidonic Acid ◽  
Acid Synthesis ◽  
Liver Cells ◽  
Isolated Liver Cells ◽  
Isolated Liver

Decreased glucagon-stimulated cyclic AMP production by isolated liver cells of rats with type 2 diabetes

1983 ◽  
Vol 32 (1) ◽  
pp. 13-26 ◽  
Author(s):  
Bernard Portha ◽  
Hilda Chamras ◽  
Yvonne Broer ◽  
Luc Picon ◽  
Gabriel Rosselin
Keyword(s):  
Type 2 Diabetes ◽  
Cyclic Amp ◽  
Liver Cells ◽  
Isolated Liver Cells ◽  
Isolated Liver

scholarly journals Amylase in Isolated Liver Cells

1960 ◽  
Vol 235 (5) ◽  
pp. 1354-1358
Author(s):  
Robert L. McGeachin ◽  
Betty Ann Potter
Keyword(s):  
Liver Cells ◽  
Isolated Liver Cells ◽  
Isolated Liver
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