Mesencephalic Human Neural Progenitor Cells Transplanted into the Adult Hemiparkinsonian Rat Striatum Lack Dopaminergic Differentiation but Improve Motor Behavior

2008 ◽  
Vol 188 (4) ◽  
pp. 373-383 ◽  
Author(s):  
Marine Hovakimyan ◽  
Stefan Jean-Pierre Haas ◽  
Oliver Schmitt ◽  
Bernd Gerber ◽  
Andreas Wree ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Motor Behavior ◽  
Neural Progenitor ◽  
Rat Striatum ◽  
Human Neural Progenitor Cells ◽  
Dopaminergic Differentiation

scholarly journals Mesencephalic human neural progenitor cells transplanted into the neonatal hemiparkinsonian rat striatum differentiate into neurons and improve motor behaviour

2006 ◽  
Vol 209 (6) ◽  
pp. 721-732 ◽  
Author(s):  
Marine Hovakimyan ◽  
Stefan Jean-Pierre Haas ◽  
Oliver Schmitt ◽  
Bernd Gerber ◽  
Andreas Wree ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Rat Striatum ◽  
Motor Behaviour ◽  
Human Neural Progenitor Cells

scholarly journals Chromosome 7 and 19 Trisomy in Cultured Human Neural Progenitor Cells

PLoS ONE ◽  
2009 ◽  
Vol 4 (10) ◽  
pp. e7630 ◽  
Author(s):  
Dhruv Sareen ◽  
Erin McMillan ◽  
Allison D. Ebert ◽  
Brandon C. Shelley ◽  
Julie A. Johnson ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Chromosome 7 ◽  
Human Neural Progenitor Cells

scholarly journals Differential epigenetic effects of chlorpyrifos and arsenic in proliferating and differentiating human neural progenitor cells

2016 ◽  
Vol 65 ◽  
pp. 212-223 ◽  
Author(s):  
Hee Yeon Kim ◽  
Susanna H. Wegner ◽  
Kirk P. Van Ness ◽  
Julie Juyoung Park ◽  
Sara E. Pacheco ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Epigenetic Effects ◽  
Human Neural Progenitor Cells

scholarly journals Xenotransplantation of Human Neural Progenitor Cells to the Subretinal Space of Nonimmunosuppressed Pigs

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Karin Warfvinge ◽  
Philip H. Schwartz ◽  
Jens Folke Kiilgaard ◽  
Morten la Cour ◽  
Michael J. Young ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Mononuclear Cell ◽  
Neural Progenitor Cells ◽  
Retinal Vasculitis ◽  
Donor Cell ◽  
Neural Progenitor ◽  
Morphological Integration ◽  
Subretinal Space ◽  
Donor Cells ◽  
Human Neural Progenitor Cells

To investigate the feasibility of transplanting human neural progenitor cells (hNPCs) to the retina of nonimmunosuppressed pigs, cultured hNPCs were injected into the subretinal space of 5 adult pigs after laser burns were applied to promote donor cell integration. Postoperatively, the retinal vessels appeared normal without signs of exudation, bleeding, or subretinal elevation. Eyes were harvested at 10–28 days. H&E consistently showed mild retinal vasculitis, depigmentation of the RPE, and marked mononuclear cell infiltrate in the choroid adjacent to the site of transplantation. Human-specific antibodies revealed donor cells in the subretinal space at 10–13 days and smaller numbers within the retina on days 12 and 13, with evidence suggesting a limited degree of morphological integration; however, no cells remained at 4 weeks. The strong mononuclear cell reaction and loss of donor cells indicate that modulation of host immunity is likely necessary for prolonged xenograft survival in this model.

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