G 619, a Dual Thromboxane Synthase Inhibitor and Thromboxane A<sub>2</sub> Receptor Antagonist, Reduces Myocardial Damage and Polymorpho-nuclear Leukocyte Accumulation following Coronary Artery Occlusion and Reperfusion in Rats

Francesco Squadrito; Mariapatrizia Ioculano; Domenica Altavilla; Basilia Zingarelli; Patrizia Canale; Giuseppe M. Campo; Antonino Saitta; Salvatore Oriti; Giacomo Spignoli; Achille P. Caputi

doi:10.1159/000139094

G 619, a Dual Thromboxane Synthase Inhibitor and Thromboxane A2 Receptor Antagonist, Reduces Myocardial Damage and Polymorpho-nuclear Leukocyte Accumulation following Coronary Artery Occlusion and Reperfusion in Rats

Pharmacology ◽

10.1159/000139094 ◽

1993 ◽

Vol 47 (3) ◽

pp. 167-175 ◽

Cited By ~ 3

Author(s):

Francesco Squadrito ◽

Mariapatrizia Ioculano ◽

Domenica Altavilla ◽

Basilia Zingarelli ◽

Patrizia Canale ◽

...

Keyword(s):

Coronary Artery ◽

Receptor Antagonist ◽

Myocardial Damage ◽

Coronary Artery Occlusion ◽

Artery Occlusion ◽

Thromboxane Synthase ◽

Leukocyte Accumulation ◽

Thromboxane Synthase Inhibitor ◽

Synthase Inhibitor

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Reduction of Myocardial Damage and Polymorphonuclear Leukocyte Accumulation Following Coronary Artery Occlusion and Reperfusion by the Thromboxane Receptor Antagonist BM 13.505

Journal of Cardiovascular Pharmacology ◽

10.1097/00005344-198913050-00006 ◽

1989 ◽

Vol 13 (5) ◽

pp. 715-722 ◽

Cited By ~ 2

Author(s):

E. F. Smith ◽

D. E. Griswold ◽

J. W. Egan ◽

L. M. Hillegass ◽

M. J. DiMartino

Keyword(s):

Coronary Artery ◽

Receptor Antagonist ◽

Polymorphonuclear Leukocyte ◽

Myocardial Damage ◽

Coronary Artery Occlusion ◽

Artery Occlusion ◽

Thromboxane Receptor ◽

Leukocyte Accumulation ◽

Thromboxane Receptor Antagonist

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Reduction of Myocardial Damage and Polymorphonuclear Leukocyte Accumulation Following Coronary Artery Occlusion and Reperfusion by the Thromboxane Receptor Antagonist BM 13.505

Journal of Cardiovascular Pharmacology ◽

10.1097/00005344-198905000-00006 ◽

1989 ◽

Vol 13 (5) ◽

pp. 715-722 ◽

Cited By ~ 32

Author(s):

E. F. Smith ◽

D. E. Griswold ◽

J. W. Egan ◽

L. M. Hillegass ◽

M. J. DiMartino

Keyword(s):

Coronary Artery ◽

Receptor Antagonist ◽

Polymorphonuclear Leukocyte ◽

Myocardial Damage ◽

Coronary Artery Occlusion ◽

Artery Occlusion ◽

Thromboxane Receptor ◽

Leukocyte Accumulation ◽

Thromboxane Receptor Antagonist

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Protective Effects of G 619, a Dual Thromboxane Synthase Inhibitor and Thromboxane A2 Receptor Antagonist, in Splanchnic Artery Occlusion Shock

Journal of Cardiovascular Pharmacology ◽

10.1097/00005344-199201000-00016 ◽

1992 ◽

Vol 19 (1) ◽

pp. 115-119 ◽

Cited By ~ 12

Author(s):

Francesco Squadrito ◽

Domenica Altavilla ◽

Basilia Zingarelli ◽

Maria P. Ioculano ◽

Giuseppe M. Campo ◽

...

Keyword(s):

Receptor Antagonist ◽

Thromboxane A2 ◽

Artery Occlusion ◽

Protective Effects ◽

Thromboxane Synthase ◽

Thromboxane A2 Receptor ◽

Thromboxane Synthase Inhibitor ◽

Splanchnic Artery ◽

Synthase Inhibitor

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In Vitro and in Vivo Pharmacological Characterization of BM-613 [N-n-Pentyl-N′-[2-(4′-methylphenylamino)-5-nitrobenzenesulfonyl]urea], a Novel Dual Thromboxane Synthase Inhibitor and Thromboxane Receptor Antagonist

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.104.079301 ◽

2004 ◽

Vol 313 (1) ◽

pp. 293-301 ◽

Cited By ~ 10

Author(s):

Julien Hanson ◽

Stephanie Rolin ◽

Denis Reynaud ◽

Na Qiao ◽

Leanne P. Kelley ◽

...

Keyword(s):

Receptor Antagonist ◽

Pharmacological Characterization ◽

Thromboxane Synthase ◽

Thromboxane Receptor ◽

Thromboxane Synthase Inhibitor ◽

Thromboxane Receptor Antagonist ◽

Synthase Inhibitor

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The dual thromboxane receptor antagonist and thromboxane synthase inhibitor EV-077 is a more potent inhibitor of platelet function than aspirin

Journal of Thrombosis and Haemostasis ◽

10.1111/j.1538-7836.2011.04446.x ◽

2011 ◽

Vol 9 (10) ◽

pp. 2109-2111 ◽

Cited By ~ 15

Author(s):

P. FONTANA ◽

P. ALBERTS ◽

K. S. SAKARIASSEN ◽

H. BOUNAMEAUX ◽

J.-P. MEYER ◽

...

Keyword(s):

Receptor Antagonist ◽

Platelet Function ◽

Potent Inhibitor ◽

Thromboxane Synthase ◽

Thromboxane Receptor ◽

Thromboxane Synthase Inhibitor ◽

Thromboxane Receptor Antagonist ◽

Synthase Inhibitor

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Basic pharmacophore of some antithrombotic agents with combined thromboxane receptor antagonist (TxRA)/thromboxane synthase inhibitor (TxSI) activity

Drug Development Research ◽

10.1002/(sici)1098-2299(199610)39:2<197::aid-ddr14>3.0.co;2-9 ◽

1996 ◽

Vol 39 (2) ◽

pp. 197-200 ◽

Cited By ~ 3

Author(s):

Yang Jie ◽

Hua Weiyi

Keyword(s):

Receptor Antagonist ◽

Antithrombotic Agents ◽

Thromboxane Synthase ◽

Thromboxane Receptor ◽

Thromboxane Synthase Inhibitor ◽

Thromboxane Receptor Antagonist ◽

Synthase Inhibitor

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Effects of a thromboxane receptor antagonist (NT-126) and a thromboxane synthase inhibitor (OKY-O46) on protamine-induced circulatory changes in dogs

Journal of Cardiothoracic and Vascular Anesthesia ◽

10.1053/jcan.2000.18449 ◽

2000 ◽

Vol 14 (6) ◽

pp. 687-692 ◽

Cited By ~ 4

Author(s):

Taro Mizutani ◽

Shinji Takahashi ◽

Shin-ichi Kihara ◽

Hidenori Toyooka

Keyword(s):

Receptor Antagonist ◽

Thromboxane Synthase ◽

Thromboxane Receptor ◽

Thromboxane Synthase Inhibitor ◽

Thromboxane Receptor Antagonist ◽

Synthase Inhibitor

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Endothelin-Receptor Antagonist FR 139317 Reduces Infarct Size in a Rabbit Model When Given Before, But Not After, Coronary Artery Occlusion

Journal of Cardiovascular Pharmacology ◽

10.1097/00005344-199701000-00014 ◽

1997 ◽

Vol 29 (1) ◽

pp. 87-92 ◽

Cited By ~ 10

Author(s):

Sandra E. Burke ◽

Richard A. Nelson

Keyword(s):

Coronary Artery ◽

Infarct Size ◽

Receptor Antagonist ◽

Rabbit Model ◽

Coronary Artery Occlusion ◽

Artery Occlusion ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor

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Novel Agents Combining Platelet Activating Factor (PAF) Receptor Antagonist with Thromboxane Synthase Inhibitor (TxSI)

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(02)00005-7 ◽

2002 ◽

Vol 12 (5) ◽

pp. 771-774 ◽

Cited By ~ 9

Author(s):

Masakazu Fujita ◽

Taketsugu Seki ◽

Haruaki Inada ◽

Kazuhiro Shimizu ◽

Akane Takahama ◽

...

Keyword(s):

Receptor Antagonist ◽

Platelet Activating Factor ◽

Novel Agents ◽

Thromboxane Synthase ◽

Thromboxane Synthase Inhibitor ◽

Paf Receptor ◽

Synthase Inhibitor ◽

Paf Receptor Antagonist

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ChemInform Abstract: Syntheses and Bioactivities of Novel Carbamates Combining Platelet Activating Factor (PAF) Receptor Antagonist with Thromboxane Synthase Inhibitor (TxSI).

ChemInform ◽

10.1002/chin.200237169 ◽

2010 ◽

Vol 33 (37) ◽

pp. no-no

Author(s):

Masakazu Fujita ◽

Taketsugu Seki

Keyword(s):

Receptor Antagonist ◽

Platelet Activating Factor ◽

Thromboxane Synthase ◽

Thromboxane Synthase Inhibitor ◽

Paf Receptor ◽

Synthase Inhibitor ◽

Paf Receptor Antagonist

Download Full-text