Probucol Attenuates a Reduction in Serum Immunoreactive Insulin Levels by Interleukin in Adrenalectomized Rats

Pharmacology ◽  
1992 ◽  
Vol 44 (6) ◽  
pp. 344-348 ◽  
Author(s):  
H. Shimizu ◽  
Y. Uehara ◽  
M. Mori
Keyword(s):  
Immunoreactive Insulin ◽  
Insulin Levels ◽  
Serum Immunoreactive Insulin ◽  
Adrenalectomized Rats

Serum immunoreactive insulin levels in intact and regenerating postmetamorphic xenopus laevis

1987 ◽  
Vol 243 (3) ◽  
pp. 453-460 ◽  
Author(s):  
Richard A. Liversage ◽  
Ramsey A. Foty ◽  
Philip D. G. Miles
Keyword(s):  
Xenopus Laevis ◽  
Immunoreactive Insulin ◽  
Insulin Levels ◽  
Serum Immunoreactive Insulin

NEONATAL ISLET CELL TRANSPLANTATION IN THE DIABETIC RAT: EFFECT ON HEPATIC ENZYME ACTIVITY AND GLUCOSE HOMEOSTASIS

1977 ◽  
Vol 74 (2) ◽  
pp. 231-241 ◽  
Author(s):  
YVONNE MANGNALL ◽  
ANNE SMYTHE ◽  
D. N. SLATER ◽  
GILLIAN R. MILNER ◽  
R. D. G. MILNER ◽  
...  
Keyword(s):  
Diabetic Animal ◽  
Pancreatic Tissue ◽  
Diabetic Rats ◽  
Neonatal Rat ◽  
Diabetic Rat ◽  
Immunoreactive Insulin ◽  
Hepatic Glycogen ◽  
Islet Cell Transplantation ◽  
Glycogen Concentration ◽  
Serum Immunoreactive Insulin

Intraperitoneal transplantation of collagenase-digested, isogeneic, neonatal rat pancreatic tissue successfully reversed streptozotocin-induced diabetes in 77% of recipients. The low serum immunoreactive insulin, hyperglycaemia, glycosuria and weight loss, characteristic of the diabetic animal, were corrected and the reduced activities of hepatic glucokinase and pyruvate kinase, and the low glycogen concentration of the liver of diabetic rats were restored to normal. Forty-three per cent of the successfully transplanted rats became normoglycaemic within 1 month of transplantation whereas 57% took from 1 to 6 months to achieve normoglycaemia and displayed a mild glucose intolerance when subjected to a glucose load. The rats which had not become normoglycaemic 6 months after transplantation showed some amelioration of the diabetic state, as shown by increased serum immunoreactive insulin and hepatic glycogen concentration and a slow weight gain compared with diabetic controls.

ADIPOSE-CELL SIZE AND IMMUNOREACTIVE INSULIN LEVELS IN OBESE AND NORMAL-WEIGHT ADULTS

The Lancet ◽  
1972 ◽  
Vol 300 (7784) ◽  
pp. 948-951 ◽  
Author(s):  
JudithS. Stern ◽  
Nina Hollander ◽  
BruceR. Batchelor ◽  
CalK. Cohn ◽  
Jules Hirsch
Keyword(s):  
Cell Size ◽  
Normal Weight ◽  
Immunoreactive Insulin ◽  
Adipose Cell ◽  
Insulin Levels ◽  
Adipose Cell Size

Effect of clofibrate on plasma glucose and serum immunoreactive insulin in patients with hyperlipoproteinemia

1974 ◽  
Vol 27 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Ralph W. Fenderson ◽  
Ignacy Sekowski ◽  
N. Chandra Mohan ◽  
Stanley Deutsch ◽  
Fred Benjamin ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Immunoreactive Insulin ◽  
Serum Immunoreactive Insulin

Intracisternal insulin alters sensitivity to CCK-induced meal suppression in baboons

1986 ◽  
Vol 250 (5) ◽  
pp. R856-R860 ◽  
Author(s):  
D. P. Figlewicz ◽  
L. J. Stein ◽  
D. West ◽  
D. Porte ◽  
S. C. Woods
Keyword(s):  
Food Intake ◽  
Plasma Insulin ◽  
Insulin Infusion ◽  
Meal Size ◽  
Immunoreactive Insulin ◽  
Gut Peptides ◽  
Insulin Levels ◽  
Glucose Levels ◽  
Total Food Intake ◽  
Single Meal

We have previously reported that intravenous administration of the octapeptide of cholecystokinin (CCK-8) is more effective in reducing single meal size in baboons at noontime than in the morning. We have also reported that immunoreactive insulin levels in the cerebrospinal fluid (CSF) are elevated after animals have recently eaten. To test whether elevated CSF insulin levels can alter the efficacy of intravenous CCK to reduce meal size we administered subthreshold doses of CCK-8 to baboons infused with either synthetic CSF or CSF and insulin (100 microU X kg-1 X day-1) via the cisterna magna. Intravenous CCK-8 alone reduced 30-min meal size from 504 +/- 121 to 378 +/- 113 kcal (n = 7, P = NS). Chronic intracisternal insulin infusion enhanced CCK-8's suppressive effects such that 30-min meal size was reduced from 544 +/- 74 to 240 +/- 108 kcal (n = 7, P less than 0.005). Intracisternal insulin infusion had no significant effect on total food intake, basal plasma insulin and glucose levels, or postprandial plasma insulin and glucose levels. These findings suggest that central insulin may contribute to food intake regulation by modulating the ability of brain-gut peptides to alter single meal size.

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