Development of diagnotors based on time-average values of plasma glucose and immunoreactive insulin levels during intravenous glucose tolerance testing

2000 ◽  
Author(s):  
Tatyana P. Denisova ◽  
Igor A. Malinov ◽  
Lidia I. Malinova ◽  
Sergey B. Brook
Keyword(s):  
Glucose Tolerance ◽  
Plasma Glucose ◽  
Immunoreactive Insulin ◽  
Intravenous Glucose ◽  
Insulin Levels ◽  
Intravenous Glucose Tolerance ◽  
Time Average ◽  
Tolerance Testing

scholarly journals Feasibility of intravenous glucose tolerance testing prior to puberty

2010 ◽  
Vol 5 (1) ◽  
pp. 51-55 ◽  
Author(s):  
Connie L. Tompkins ◽  
William Cefalu ◽  
Eric Ravussin ◽  
Michael Goran ◽  
Arlette Soros ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Intravenous Glucose ◽  
Intravenous Glucose Tolerance ◽  
Tolerance Testing

Feasibility of intravenous glucose tolerance testing prior to puberty

2009 ◽  
pp. 1-5 ◽  
Author(s):  
Connie Tompkins ◽  
William Cefalu ◽  
Eric Ravussin ◽  
Michael Goran ◽  
Arlette Soros ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Intravenous Glucose ◽  
Intravenous Glucose Tolerance ◽  
Tolerance Testing

scholarly journals First test effect in intravenous glucose tolerance testing

2013 ◽  
Vol 16 (2) ◽  
pp. 129-137 ◽  
Author(s):  
Heba M Ismail ◽  
Kama S White ◽  
Jeffrey P Krischer ◽  
H Peter Chase ◽  
David Cuthbertson ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Intravenous Glucose ◽  
Intravenous Glucose Tolerance ◽  
Tolerance Testing

Effect of adrenaline on insulin secretion in rats treated chronically with adrenaline

1976 ◽  
Vol 54 (6) ◽  
pp. 870-875 ◽  
Author(s):  
Suzanne Rousseau-Migneron ◽  
André Nadeau ◽  
Jacques LeBlanc
Keyword(s):  
Insulin Secretion ◽  
Glucose Tolerance ◽  
Plasma Glucose ◽  
Basal Insulin ◽  
Plasma Insulin ◽  
Intravenous Glucose ◽  
Insulin Levels ◽  
Glucose Levels ◽  
Plasma Insulin Levels ◽  
Adrenaline Infusion

To determine whether rats could adapt to a chronic exogenous supply of adrenaline by a decrease in the well-known inhibitory effect of adrenaline on insulin secretion, plasma glucose and insulin levels were measured in unanesthetized control and adrenaline-treated rats (300 μg/kg twice a day for 28 days) during an adrenaline infusion (0.75 μg kg−1 min−1), after an acute glucose load (0.5 g/kg), and during the simultaneous administration of both agents. Chronic treatment with adrenaline did not modify the initial glucose levels but it greatly diminished the basal insulin values (21.57 ± 2.48 vs. 44.69 ± 3.3 μU/ml, p < 0.01). In the control rats, despite the elevated glucose concentrations, a significant drop in plasma insulin levels was observed within the first 15 min of adrenaline infusion, followed by a period of recovery. In the adrenaline-treated group, in which plasma glucose levels were lower than in control animals, plasma insulin levels did not drop as in control rats, but a significant increase was found after 30 min of infusion. During the intravenous glucose tolerance test, the plasma glucose and insulin responses showed similar patterns; however, during the concomitant adrenaline infusion, the treated rats showed a better glucose tolerance than their controls. These results indicate that rats chronically treated with adrenaline adapt to the diabetogenic effect of an infusion of adrenaline by having a lower inhibition of insulin release, although the lower basal insulin levels may indicate a greater sensitivity to endogenous insulin.

Low Vitamin K Intake Effects on Glucose Tolerance in Rats

1999 ◽  
Vol 69 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Sakamoto ◽  
Wakabayashi ◽  
Sakamoto
Keyword(s):  
Glucose Tolerance ◽  
Vitamin K ◽  
Plasma Glucose ◽  
Insulin Response ◽  
Glucose Load ◽  
Intravenous Glucose ◽  
Intravenous Glucose Tolerance ◽  
Glucose Tolerance Tests ◽  
Early Insulin Response ◽  
Intravenous Glucose Tolerance Tests

To investigate the effects of vitamin K (VK) on pancreatic function, intravenous glucose tolerance tests were performed in rats fed with and without low VK diet (inclucing less than 20% required vitamin K1). Plasma glucose and immuno-reactive insulin (IRI) were determined. It was found that at 0 min., plasma glucose and IRI levels in low VK group were slightly less than in the control (glucose, 204.5 ± 21.7 vs. 229 ± 19.6 mg/dl, IRI, 6.6 ± 1.3 vs. 9.3 ± 1.8 ng/ml mean ± SEM). At 3 min. after glucose administration, plasma glucose was higher (391.8 ± 25.6 vs. 371.8 ± 18.7 mg/dl) and IRI, lower (11.8 ± 2.1 vs. 18.2 ± 3.6 ng/ml) in the low VK group. The disappearance rate of plasma glucose in the low VK group at 5–10 min. was significantly less than in the control (6.7 ± 2.2 vs. 11.9 ± 1.8 mg/ dl/min.). Incremental IRI area at 0 to 5 min. in the low VK group is less than in the control (15.2 ± 4.4 vs. 25.0 ± 9.1 ng/ml/min.), but at 5–60 min. and 0–60 min., it was found to be significantly higher compared to the control (210.3 ± 55.2 vs. 32.5 ± 47.1 ng/ml/min. at 5–60 min.). Dietary low VK intake would thus appear to induce a tendency of poor early insulin response, and late hyperinsulinemia to the glucose load in rats.

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