Effects of 5-Lipoxygenase Inhibition on Cardiac Anaphylaxis in Isolated Guinea Pig Hearts

Pharmacology ◽  
1989 ◽  
Vol 38 (6) ◽  
pp. 352-362 ◽  
Author(s):  
S.R. Jolly ◽  
J. Travis ◽  
R.G. Van Inwegen
Keyword(s):  
Guinea Pig ◽  
Cardiac Anaphylaxis ◽  
Lipoxygenase Inhibition

Protective effects of calcitonin gene-related peptide-mediated evodiamine on guinea-pig cardiac anaphylaxis

2003 ◽  
Vol 367 (3) ◽  
pp. 306-311 ◽  
Author(s):  
Wei-Qing Rang ◽  
Yan-Hua Du ◽  
Chang-Ping Hu ◽  
Feng Ye ◽  
Gui-Shan Tan ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Calcitonin Gene Related Peptide ◽  
Protective Effects ◽  
Cardiac Anaphylaxis ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals Acetyl glyceryl ether phosphorylcholine (AGEPC). A putative mediator of cardiac anaphylaxis in the guinea pig.

1984 ◽  
Vol 54 (2) ◽  
pp. 117-124 ◽  
Author(s):  
R Levi ◽  
J A Burke ◽  
Z G Guo ◽  
Y Hattori ◽  
C M Hoppens ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Glyceryl Ether ◽  
Cardiac Anaphylaxis

The effect of calcium on cardiac anaphylaxis in guinea-pig Langendorff heart preparations

1985 ◽  
Vol 16 (5) ◽  
pp. 415-424 ◽  
Author(s):  
Ralph D. Tanz ◽  
Nancy Kettelkamp ◽  
Carol A. Hirshman
Keyword(s):  
Guinea Pig ◽  
Cardiac Anaphylaxis

scholarly journals Glucagon Effects on3H-Histamine Uptake by the Isolated Guinea-Pig Heart during Anaphylaxis

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Mirko Rosic ◽  
Oberdan Parodi ◽  
Vladimir Jakovljevic ◽  
Maja Colic ◽  
Vladimir Zivkovic ◽  
...  
Keyword(s):  
Free Radicals ◽  
Guinea Pig ◽  
Histamine Release ◽  
Coronary Circulation ◽  
Histamine Level ◽  
Guinea Pig Heart ◽  
Cardiac Anaphylaxis ◽  
Endogenous Histamine ◽  
No Release ◽  
Histamine Uptake

We estimated the influence of acute glucagon applications on3H-histamine uptake by the isolated guinea-pig heart, during a single3H-histamine passage through the coronary circulation, before and during anaphylaxis, and the influence of glucagon on level of histamine, NO,O2-, and H2O2in the venous effluent during anaphylaxis. Before anaphylaxis, glucagon pretreatment does not change3H-histamine Umax and the level of endogenous histamine. At the same time, in the presence of glucagon,3H-histamine Unet is increased and backflux is decreased when compared to the corresponding values in the absence of glucagon. During anaphylaxis, in the presence of glucagon, the values of3H-histamine Umax and Unet are significantly higher and backflux is significantly lower in the presence of glucagon when compared to the corresponding values in the absence of glucagon. The level of endogenous histamine during anaphylaxis in the presence of glucagon (6.9–7.38 × 10−8 μM) is significantly lower than the histamine level in the absence of glucagon (10.35–10.45 × 10−8 μM). Glucagon pretreatment leads to a significant increase in NO release (5.69 nmol/mL) in comparison with the period before glucagon administration (2.49 nmol/mL). Then, in the presence of glucagon,O2-level fails to increase during anaphylaxis. Also, our results show no significant differences in H2O2levels before, during, and after anaphylaxis in the presence of glucagon, but these values are significantly lower than the corresponding values in the absence of glucagon. In conclusion, our results show that glucagon increases NO release and prevents the increased release of free radicals during anaphylaxis, and decreases histamine level in the venous effluent during cardiac anaphylaxis, which may be a consequence of decreased histamine release and/or intensified histamine capturing by the heart during anaphylaxis.

Protective effects of calcitonin gene-related peptide on guinea-pig cardiac anaphylaxis

2000 ◽  
Vol 361 (2) ◽  
pp. 161-165 ◽  
Author(s):  
W. Dai ◽  
F.-W. Zhou ◽  
Q.-J. Song ◽  
Y.-J. Li ◽  
H.-W. Deng ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Calcitonin Gene Related Peptide ◽  
Protective Effects ◽  
Cardiac Anaphylaxis ◽  
Related Peptide ◽  
Calcitonin Gene
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