Effects of Nitric Oxide Synthases on Detrusor Overactivity after Removal of Bladder Outlet Obstruction in Rats

2008 ◽  
Vol 81 (1) ◽  
pp. 107-112 ◽  
Author(s):  
H.S. Kim ◽  
J.C. Kim ◽  
M.S. Choo
Keyword(s):  
Nitric Oxide ◽  
Detrusor Overactivity ◽  
Bladder Outlet Obstruction ◽  
Outlet Obstruction ◽  
Nitric Oxide Synthases

scholarly journals Effect of detrusor overactivity on the expression of aquaporins and nitric oxide synthase in rat urinary bladder following bladder outlet obstruction

2013 ◽  
Vol 7 (5-6) ◽  
pp. 268 ◽  
Author(s):  
Sun-Ouck Kim ◽  
Dongjune Choi ◽  
Seung Hee Song ◽  
Kyu Youn Ahn ◽  
Dongdeuk Kwon ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Urinary Bladder ◽  
Detrusor Overactivity ◽  
Bladder Outlet Obstruction ◽  
Outlet Obstruction ◽  
Control Group ◽  
Rat Urinary Bladder ◽  
Oxide Synthase ◽  
Nos Isoforms

Background: Aquaporins (AQPs) have recently been reported to be expressed in rat and human urothelium. Nitric oxide (NO) is thought to play a role in the bladder overactivity related to bladder outlet obstruction (BOO). The purpose of this study is to investigate the effect of BOO on the expression of AQP2-3 and nitric oxide synthase (NOS) isoforms in rat urothelium.Methods: Female Sprague-Dawley rats (230-240 g, n = 60) were divided into 2 groups. The control group (n = 30) and the partial bladder outlet obstruction (BOO) group (n = 30). After 4 weeks, we performed a urodynamic study to measure the contraction interval and contraction pressure. The expression and cellular localization of AQP2-3, endothelial nitric oxide synthase (eNOS) and neuronalnitric oxide synthase (nNOS) were determined by Western blot and immunohistochemistry.Results: On the cystometrogram, the estimated contraction interval time (minutes, mean ± SE) was significantly lower in the BOO group (3.0 ± 0.9) than in the control group (6.3 ± 0.4; p < 0.05). AQP2 was localized in the cytoplasm of the epithelium, whereas AQP3 was found only in the cell membrane of the epithelium. The protein expression of AQP2-3, eNOS and nNOS was significantly increased in the BOO group.Conclusion: Detrusor overactivity induced by BOO causes a significant increase in the expression of AQP2-3, eNOS, and nNOSin rat urinary bladder. This may imply that the AQPs and NOS isoforms have a functional role in the bladder dysfunction that occurs in association with BOO.

Age and Bladder Outlet Obstruction Are Independently Associated with Detrusor Overactivity in Patients with Benign Prostatic Hyperplasia

2008 ◽  
Vol 54 (2) ◽  
pp. 419-426 ◽  
Author(s):  
Matthias Oelke ◽  
Joyce Baard ◽  
Hessel Wijkstra ◽  
Jean J. de la Rosette ◽  
Udo Jonas ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Detrusor Overactivity ◽  
Bladder Outlet Obstruction ◽  
Outlet Obstruction ◽  
Prostatic Hyperplasia

scholarly journals Effects of nitric oxide inhibitors in mice with bladder outlet obstruction

2017 ◽  
Vol 43 (2) ◽  
pp. 356-366 ◽  
Author(s):  
Marcy Lancia Pereira ◽  
Carlos Arturo Levi D’ancona ◽  
Julio Alejandro Rojas-Moscoso ◽  
Antonio Celso Saragossa Ramos Filho ◽  
Fabiola Zakia Mónica ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Bladder Outlet Obstruction ◽  
Outlet Obstruction ◽  
Nitric Oxide Inhibitors

Preventive Effect of Hydrogen Water on the Development of Detrusor Overactivity in a Rat Model of Bladder Outlet Obstruction

2016 ◽  
Vol 195 (3) ◽  
pp. 780-787 ◽  
Author(s):  
Nozomu Miyazaki ◽  
Osamu Yamaguchi ◽  
Masanori Nomiya ◽  
Ken Aikawa ◽  
Junko Kimura
Keyword(s):  
Rat Model ◽  
Detrusor Overactivity ◽  
Bladder Outlet Obstruction ◽  
Outlet Obstruction ◽  
Preventive Effect ◽  
Hydrogen Water

The Evolution of Detrusor Overactivity After Watchful Waiting, Medical Therapy and Surgery in Patients with Bladder Outlet Obstruction

2003 ◽  
Vol 169 (2) ◽  
pp. 535-539 ◽  
Author(s):  
COSIMO de NUNZIO ◽  
GIORGIO FRANCO ◽  
ANDREA ROCCHEGIANI ◽  
FRANCESCO IORI ◽  
COSTANTINO LEONARDO ◽  
...  
Keyword(s):  
Medical Therapy ◽  
Detrusor Overactivity ◽  
Bladder Outlet Obstruction ◽  
Watchful Waiting ◽  
Outlet Obstruction
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