Formation of α-Methyldopamine (‘Catecholamphetamine’) from p-Hydroxyamphetamine by Rat Brain Microsomes

Pharmacology ◽  
1979 ◽  
Vol 19 (5) ◽  
pp. 256-260 ◽  
Author(s):  
Andrew R. Hoffman ◽  
Rama Sastry ◽  
Julius Axelrod
Keyword(s):  
Rat Brain ◽  
Brain Microsomes

Ethanol and inositol 1,4,5-trisphosphate mobilize calcium from rat brain microsomes

Alcohol ◽  
1989 ◽  
Vol 6 (6) ◽  
pp. 431-436 ◽  
Author(s):  
Tina Machu ◽  
John J. Woodward ◽  
Steven W. Leslie
Keyword(s):  
Rat Brain ◽  
Inositol 1,4,5 Trisphosphate ◽  
Brain Microsomes

scholarly journals Neurosteroid metabolism. 7α-Hydroxylation of dehydroepiandrosterone and pregnenolone by rat brain microsomes

1992 ◽  
Vol 288 (3) ◽  
pp. 959-964 ◽  
Author(s):  
Y Akwa ◽  
R F Morfin ◽  
P Robel ◽  
E E Baulieu
Keyword(s):  
Rat Brain ◽  
Microsomal Protein ◽  
Optimal Conditions ◽  
Hydroxylated Metabolites ◽  
Enzymic Reaction ◽  
Polar Metabolites ◽  
Brain Microsomes ◽  
Prepubertal Rats ◽  
Derivatives Of

Two ‘neurosteroids’, dehydroepiandrosterone (DHEA) and pregnenolone (PREG), are converted by rat brain microsomes into polar metabolites, identified as the respective 7 alpha-hydroxylated (7 alpha-OH) derivatives by the ‘twin ion’ technique of g.l.c.-m.s. with deuterated substrates. The enzymic reaction requires NADPH and is stimulated 2-4-fold by EDTA. Under optimal conditions (pH 7.4, 0.5 mM-NADPH, 1 mM-EDTA), the Km values for DHEA and PREG are 13.8 and 4.4 microM respectively, and the Vmax. values are 322 and 38.8 pmol/min per mg of microsomal protein respectively. Trace amounts of putative 7 beta-OH derivatives of DHEA and PREG are detected. Oestradiol, at a pharmacological concentration of 5 microM, inhibits DHEA and PREG 7 alpha-hydroxylation. Formation of 7 alpha-hydroxylated metabolites is low in prepubertal rats and increases 5-fold in adults. Derivatives of PREG and DHEA, such as PREG sulphate, DHEA sulphate, progesterone and 3 alpha-hydroxy-5 alpha-pregnan-20-one, are known to be neuroactive. Therefore the quantitatively important metabolism to 7 alpha-OH compounds may contribute to the control of neurosteroid activity in brain.

ACYLATION OF LYSOPHOSPHATIDYLSERINE BY RAT BRAIN MICROSOMES

1979 ◽  
Vol 33 (5) ◽  
pp. 1061-1066 ◽  
Author(s):  
O. A. James ◽  
G. MacDonald ◽  
W. Thompson
Keyword(s):  
Rat Brain ◽  
Brain Microsomes

CMP-Dependent Degradation of Platelet-Activating Factor (PAF) by Rat Brain Microsomes

1997 ◽  
pp. 1029-1034
Author(s):  
Ermelinda Francescangeli ◽  
Serena Porcellati ◽  
Gianfrancesco Goracci
Keyword(s):  
Rat Brain ◽  
Platelet Activating Factor ◽  
Brain Microsomes

Microsomal Protein Mediates a pH-Dependent Fusion of Liposomes to Rat Brain Microsomes

1990 ◽  
Vol 9 (4) ◽  
pp. 253-261 ◽  
Author(s):  
Roberto Pistolesi ◽  
Lanfranco Corazzi ◽  
Giuseppe Arienti
Keyword(s):  
Rat Brain ◽  
Microsomal Protein ◽  
Brain Microsomes ◽  
Ph Dependent

Comparing induced and non-induced rat brain microsomes from xenotech

2018 ◽  
Vol 33 (1) ◽  
pp. S77
Author(s):  
Ying Liu ◽  
Jiansheng Huang ◽  
Kevin Westland ◽  
Aaron Hilgedick ◽  
Stephanie Helmstetter ◽  
...  
Keyword(s):  
Rat Brain ◽  
Brain Microsomes

Paraquat- and Diquat-Induced Oxygen Radical Generation and Lipid Peroxidation in Rat Brain Microsomes

2002 ◽  
Vol 131 (4) ◽  
pp. 565-570 ◽  
Author(s):  
K. Yumino ◽  
I. Kawakami ◽  
M. Tamura ◽  
T. Hayashi ◽  
M. Nakamura
Keyword(s):  
Lipid Peroxidation ◽  
Rat Brain ◽  
Oxygen Radical ◽  
Brain Microsomes ◽  
Radical Generation
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