Mechanisms of the origin of a G-positive band within the secondary constriction region of human chromosome 9

1995 ◽  
Vol 69 (3-4) ◽  
pp. 235-239 ◽  
Author(s):  
M.J. Macera ◽  
R.S. Verma ◽  
R.A. Conte ◽  
M.G. Bialer ◽  
V.R. Klein
1992 ◽  
Vol 103 (4) ◽  
pp. 919-923
Author(s):  
S. Luke ◽  
R.S. Verma ◽  
R.A. Conte ◽  
T. Mathews

Pericentric inversion of the secondary constriction region (qh) of human chromosome 9 is a frequent occurrence. This structural alteration is regarded as a normal familial variant, termed heteromorphism, and is inherited in a Mendelian fashion without any apparent phenotypic consequences. We characterized the qh region of chromosome 9 from five individuals using a series of molecular cytogenetic techniques. Four out of the five individuals have an additional area composed of alphoid DNA sequences on the inverted chromosome 9 while one case was found to have an apparently intact alphoid DNA sequence. Although the direct function(s) of alphoid DNA sequences remain unclear, the centromeric breakage involving these sequences in inverted chromosome 9 raises a series of questions pertaining to the monocentric, dicentric and pseudodicentric nature of pericentric inversions. Nevertheless, these findings have prompted us to suggest that the structural organization of alphoid DNA sequences of the centromeric region of chromosome 9 are apparently “breakage prone” and may be associated with a higher incidence of pericentric inversions. Furthermore, the hierarchical organization of various satellite DNA families (alpha-satellite, beta-satellite and satellite III) within the primary and secondary constriction regions of chromosomes 9 are elucidated here.


Genomics ◽  
1992 ◽  
Vol 14 (2) ◽  
pp. 225-231 ◽  
Author(s):  
Suk P. Oh ◽  
Reginald W. Taylor ◽  
Donald R. Gerecke ◽  
Julie M. Rochelle ◽  
Michael F. Seldin ◽  
...  

2001 ◽  
Vol 130 (2) ◽  
pp. 118-126 ◽  
Author(s):  
Lena K. Eklund ◽  
Khaleda Islam ◽  
Peter Söderkvist ◽  
M.Quamrul Islam

1987 ◽  
Vol 13 (6) ◽  
pp. 689-693 ◽  
Author(s):  
Christina T. Teng ◽  
Brian T. Pentecost ◽  
Angus Marshall ◽  
Amy Solomon ◽  
Barbara H. Bowman ◽  
...  

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