Immunoglobulin heavy chain and α T-cell receptor genes rearrange in T-cell leukemia associated with a t(14;14) (q11.2;q32) translocation

1990 ◽  
Vol 53 (2-3) ◽  
pp. 155-160 ◽  
Author(s):  
S.C. Jhanwar ◽  
A. de Sostoa ◽  
L.A. Doucette ◽  
D.N. Posnett
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Heavy Chain ◽  
Immunoglobulin Heavy Chain ◽  
Cell Receptor ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
T Cell Receptor Genes

scholarly journals Multiclonality and altered RFLP patterns for immunoglobulin heavy-chain and T-cell receptor genes in relapsing lymphomas

1994 ◽  
Vol 5 ◽  
pp. S75-S78 ◽  
Author(s):  
J. Lindh ◽  
B. Linderholm ◽  
A. Lindström ◽  
H. Hagberg ◽  
C. Sundström ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Heavy Chain ◽  
Immunoglobulin Heavy Chain ◽  
Cell Receptor ◽  
T Cell Receptor Genes

scholarly journals T-cell receptor chain Vbeta subunit staining to quantify the malignant clone in adult T-cell leukemia

Retrovirology ◽  
2015 ◽  
Vol 12 (S1) ◽  
Author(s):  
Aileen G Rowan ◽  
Paul Fields ◽  
Graham P Taylor ◽  
Charles RM Bangham
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Receptor Chain

scholarly journals T Cell Receptor Vβ Staining Identifies the Malignant Clone in Adult T cell Leukemia and Reveals Killing of Leukemia Cells by Autologous CD8+ T cells

2016 ◽  
Vol 12 (11) ◽  
pp. e1006030 ◽  
Author(s):  
Aileen G. Rowan ◽  
Aviva Witkover ◽  
Anat Melamed ◽  
Yuetsu Tanaka ◽  
Lucy B. M. Cook ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Cd8 T Cells ◽  
Cell Receptor ◽  
Leukemia Cells ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
T Cell Receptor Vβ

Double-negative (CD4- CD8-) T cells from adult T-cell leukemia patients also have poor expression of the T-cell receptor alpha beta/CD3 complex

Blood ◽  
1993 ◽  
Vol 81 (4) ◽  
pp. 1032-1039 ◽  
Author(s):  
H Suzushima ◽  
N Asou ◽  
S Nishimura ◽  
K Nishikawa ◽  
JX Wang ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chain Gene ◽  
Double Negative ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Alpha Beta

Abstract We present four patients with adult T-cell leukemia (ATL) derived from a novel T-cell subset (CD4-, CD8- [double-negative, DN], T-cell receptor [TCR] alpha beta+). In the ATL cells of these patients, neither gene nor surface expression of CD4 and CD8 antigens was detected. Clinical and laboratory data showed no difference between DN- ATL and CD4+ATL patients. In contrast to typical CD4+ATL cells, DN-ATL cells were shown to express the protein and messenger RNA (mRNA) for S100 beta in immunocytochemical assay and the reverse-transcription polymerase chain reaction assay. The mean fluorescence intensity of the TCR/CD3 complex was extremely low in all four DN-ATL patients as well as in typical CD4+ ATL. All four patients had TCR beta and gamma chain gene rearrangements, with deletion of TCR delta chain gene and mRNA expression for TCR alpha, beta, and CD3 delta but not for TCR gamma and delta chain genes. Thus, CD4- CD8- TCR alpha beta T cells are also a target for human T-cell lymphotrophic virus type I-induced leukemogenesis. In addition, expression of the TCR alpha beta/CD3 complex on the DN-ATL cells was further diminished by the addition of anti-CD3 or anti-TCR alpha beta monoclonal antibody. These results suggest that the decreased expression of the TCR alpha beta/CD3 complex by ATL cells plays a key role in the development of ATL, irrespective of CD4 expression.

Polymorphism of the immunoglobulin heavy chain T cell receptor β-chain genes in Graves' disease

1987 ◽  
Vol 116 (1_Suppl) ◽  
pp. S149-S151 ◽  
Author(s):  
A. Demaine ◽  
K. I. Welsh ◽  
B. S. Hawe ◽  
Nadir R. Farid
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Heavy Chain ◽  
Immunoglobulin Heavy Chain ◽  
Cell Receptor ◽  
Graves Disease ◽  
Β Chain
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