Association of membranous nephropathy with T-cell receptor constant ? chain and immunoglobulin heavy chain switch region polymorphisms

1988 ◽  
Vol 27 (1) ◽  
pp. 19-23 ◽  
Author(s):  
A. G. Demaine ◽  
R. W. Vaughan ◽  
D. H. Taube ◽  
K. I. Welsh
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Heavy Chain ◽  
Membranous Nephropathy ◽  
Immunoglobulin Heavy Chain ◽  
Cell Receptor ◽  
Switch Region

Polymorphism of the immunoglobulin heavy chain T cell receptor β-chain genes in Graves' disease

1987 ◽  
Vol 116 (1_Suppl) ◽  
pp. S149-S151 ◽  
Author(s):  
A. Demaine ◽  
K. I. Welsh ◽  
B. S. Hawe ◽  
Nadir R. Farid
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Heavy Chain ◽  
Immunoglobulin Heavy Chain ◽  
Cell Receptor ◽  
Graves Disease ◽  
Β Chain

Analysis of Hypermutation in a Mixed T-Cell Receptor β/Immunoglobulin Heavy Chain Passenger Transgene

2008 ◽  
Vol 764 (1) ◽  
pp. 192-194
Author(s):  
J. M. JOHNSTON ◽  
S. R. IHYER ◽  
K-F. TAI ◽  
R. S. SMITH ◽  
N. L. NADON ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Heavy Chain ◽  
Immunoglobulin Heavy Chain ◽  
Cell Receptor

scholarly journals Regional location of T cell receptor gene Ti alpha on human chromosome 14.

1985 ◽  
Vol 162 (1) ◽  
pp. 387-392 ◽  
Author(s):  
P E Barker ◽  
H D Royer ◽  
F H Ruddle ◽  
E L Reinherz
Keyword(s):  
T Cell ◽  
Human Chromosome ◽  
T Cell Receptor ◽  
Heavy Chain ◽  
Immunoglobulin Heavy Chain ◽  
Cell Receptor ◽  
Chromosome 14 ◽  
Chain Locus ◽  
Human T Cell ◽  
Heavy Chain Locus

The chromosomal location of Ti alpha was determined by hybridization of a radiolabeled cDNA for the alpha chain of human T cell receptor with 12 human X mouse cell hybrid DNAs cleaved with BamHI. Seven hybrids contained human Ti alpha, while the remaining five lacked it. Only human chromosome 14 matched the distribution of human Ti alpha signal across the mapping panel. Hybrids segregating a chromosome 14 translocation were used to demonstrate that Ti alpha is in the region 14pter greater than 14q21. Thus, the alpha and beta chain genes that contribute structural components to the Ti moiety of the human T cell receptor lie on different chromosomes. In humans, the immunoglobulin heavy chain locus and Ti alpha are in different regions of chromosome 14, with Ti alpha more proximal and the immunoglobulin heavy chain locus more distal.

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