scholarly journals Dose-Dependent New Bone Formation by Extracorporeal Shock Wave Application on the Intact Femur of Rabbits

2008 ◽  
Vol 41 (1) ◽  
pp. 44-53 ◽  
Author(s):  
T. Tischer ◽  
S. Milz ◽  
C. Weiler ◽  
C. Pautke ◽  
J. Hausdorf ◽  
...  
Keyword(s):  
Shock Wave ◽  
Bone Formation ◽  
New Bone Formation ◽  
Extracorporeal Shock Wave ◽  
Dose Dependent ◽  
Intact Femur

scholarly journals lncRNA NEAT1-let 7b-P21 axis mediates the proliferation of neural stem cells cultured in vitro promoted by radial extracorporeal shock wave

2022 ◽  
Author(s):  
Kun Han ◽  
Nan Kang ◽  
Xiaotong Yu ◽  
Jie Lu ◽  
Yuewen Ma
Keyword(s):  
Shock Wave ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Optimal Dose ◽  
Cell Counting ◽  
Extracorporeal Shock Wave ◽  
Lncrna Neat1 ◽  
Dose Dependent ◽  
Dose Dependent Effect

Abstract In previous studies, we found radial extracorporeal shock wave (rESW), can promote the proliferation of neural stem cells（NSCs）. Emerging evidence suggests that lncRNA NEAT1 can regulate NSCs proliferation. Whether lncRNA NEAT1 plays a role in the proliferation of NSC induced by shock waves is unclear. Cell Counting Kit-8（CCK 8） method was used to detect the proliferation of NSCs, and the relative protein and mRNA expression of related genes of Nestin, Cyclin D1 and P21 were detected by Western Blot and Quantitative real-time PCR（RT-qPCR）respectively. Immunofluorescence staining was used to observe the changes in the number of BrdU/nestin positive cells. Overexpression of NEAT1 and let 7b in cells were used to explore whether rESW can rescue the decreased number of NSCs.We found that the optimal dose of R15 transmitter promoting NSCs proliferation is 1.5 bar, 500 pulse, 2 Hz. 1.2-1.5bar showed a dose-dependent effect on the proliferation of NSCs, but it was negatively correlated with the proliferation effect of NSC when it was more than 1.5bar. We revealed that let 7b-P21 axis was involved in regulating the inhibition of NSC proliferation which was activated by NEAT1 in NSCs. In addition, we demonstrated that rESW treatment resulted in the decrease of NEAT1 expression, which was accompanied by the improved biological function including proliferation.Our results confirm that low-intensity rESW（1.5bar，500pulse，2Hz） can promote the proliferation of NSCs through NEAT1-let 7b-P21 axis.

scholarly journals Extracorporeal Shock Wave Therapy Promotes Osteogenic Differentiation in a Rabbit Osteoporosis Model

2021 ◽  
Vol 12 ◽  
Author(s):  
Baofeng Li ◽  
Renkai Wang ◽  
Xianyin Huang ◽  
Yongliang Ou ◽  
Zhenyu Jia ◽  
...  
Keyword(s):  
Shock Wave ◽  
Bone Formation ◽  
Osteogenic Differentiation ◽  
Extracorporeal Shock Wave Therapy ◽  
Shock Wave Therapy ◽  
Detailed Mechanism ◽  
Extracorporeal Shock Wave ◽  
Osteoblast Maturation

Extracorporeal shock wave therapy (ESWT) has been identified to accelerate bone formation. However, detailed mechanism has not been fully explained. In this study, we found that ESWT promoted osteoblast formation in vitro. Local ESW treatment of femur increased bone formation in vivo. Furthermore, changing the density or frequency of energy, there was no statistical difference in osteogenic differentiation. Therapeutically, local ESW therapy relieved bone loss and increased the number of bone trabecular in a rabbit osteoporosis model and promoted endogenous levels of SMAD2 protein expression. Thus, ESWT may be a potential therapy by promoting osteoblast maturation through TGF-β/SMAD2 pathway.

scholarly journals Effects of Extracorporeal Shock Wave Therapy in The Maxillofacial Surgery Practice – A Systematic Review

2019 ◽  
Vol 3 (4) ◽  
pp. 186
Author(s):  
Enes Özkan ◽  
Tuğba Haliloğlu Özkan
Keyword(s):  
Systematic Review ◽  
Shock Wave ◽  
Biological Effect ◽  
Web Of Science ◽  
Maxillofacial Surgery ◽  
Extracorporeal Shock Wave Therapy ◽  
Shock Wave Therapy ◽  
Extracorporeal Shock Wave ◽  
Current Systematic Review ◽  
Dose Dependent

This review intends to provide researchers with a brief summary of extracorporeal Shock Wave Therapy (ESWT), and to bring new perspectives by systematic reviewing of the available data on the results of the various effects of ESWT regarding dentistry and the maxillofacial area. Literature search was conducted on December 2017 using the PubmedMedline, Google Scholar, Scopus and Web of Science databases.Articles between 1989 and 2018 were included.Search was performed using the keywords ‘alveolar, dentoalveolar, maxilla, mandibular, oral and sialolthiasis’ words in combination with ‘shock wave or shockwave’. The studies that were decided to include to this systematic review (n: 35) mostly consist of experimental and clinical studies. The current systematic review stated that ESWT has a success rate of up to 50% in the treatment of sialolithiasis. Shock wave therapy has also different dose-dependent effects on each tissue in the intraoral region. Shock wave parameters that will bring optimal biological effect to any treatment indication are yet to be clarified.International Journal of Human and Health Sciences Vol. 03 No. 04 October’19 Page : 186-195

Dose-Dependent Resorption of Allograft by rhBMP-2 Uncompensated by New Bone Formation—A Canine Study With Implants and Zoledronate

2018 ◽  
Vol 33 (4) ◽  
pp. 1215-1221.e1 ◽  
Author(s):  
Rasmus Cleemann ◽  
Joan E. Bechtold ◽  
Mette Sorensen ◽  
Kjeld Soballe ◽  
Jorgen Baas
Keyword(s):  
Bone Formation ◽  
New Bone Formation ◽  
Dose Dependent ◽  
Canine Study
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