Growth Hormone-Releasing Hormone-Synthesizing Neurons Are a Subpopulation of Somatostatin Receptor-Labelled Cells in the Rat Arcuate Nucleus: A Combined in situ Hybridization and Receptor Light-Microscopic Radioautographic Study

1992 ◽  
Vol 56 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Jêrôme Bertherat ◽  
Pascal Dournaud ◽  
Anne Bérod ◽  
Elisabeth Normand ◽  
Bertrand Bloch ◽  
...  
Keyword(s):  
Growth Hormone ◽  
In Situ Hybridization ◽  
Arcuate Nucleus ◽  
Somatostatin Receptor ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone

scholarly journals Growth Hormone-Releasing Hormone Neurons in the Arcuate Nucleus Express Both Sst1 and Sst2 Somatostatin Receptor Genes

Endocrinology ◽  
1998 ◽  
Vol 139 (3) ◽  
pp. 1450-1453 ◽  
Author(s):  
Gloria S. Tannenbaum ◽  
Wan-Hui Zhang ◽  
Martine Lapointe ◽  
Philip Zeitler ◽  
Alain Beaudet
Keyword(s):  
Growth Hormone ◽  
Arcuate Nucleus ◽  
Somatostatin Receptor ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone

Identification of target cells for growth hormone's action in the arcuate nucleus

1995 ◽  
Vol 269 (4) ◽  
pp. E716-E722
Author(s):  
K. A. Burton ◽  
E. B. Kabigting ◽  
R. A. Steiner ◽  
D. K. Clifton
Keyword(s):  
Growth Hormone ◽  
In Situ Hybridization ◽  
Arcuate Nucleus ◽  
Feedback Mechanism ◽  
Target Cells ◽  
Growth Hormone Releasing Hormone ◽  
Short Loop ◽  
Loop Feedback ◽  
The Brain

Growth hormone (GH) participates in the regulation of its own secretion by acting through a short-loop feedback mechanism to regulate the synthesis and secretion of somatostatin (SS) and growth hormone-releasing hormone (GHRH). The mechanism of GH's action in certain peripheral targets involves the induction of c-fos. Similarly, we hypothesized that GH induces the expression of c-fos mRNA in SS and GHRH neurons in the hypothalamus. Using in situ hybridization, we observed a significant induction of c-fos mRNA in the arcuate nucleus of human GH-treated compared with control animals. Contrary to our hypothesis, only 11% of GHRH mRNA-containing and 5% of SS mRNA-containing neurons colabeled for c-fos mRNA. These findings indicate that GH feedback on the hypothalamus includes the induction of c-fos mRNA primarily in neurons other than GHRH and SS in the arcuate nucleus and suggest that these unidentified neurons located in the arcuate nucleus are directly involved in transducing the effects of GH in the brain.

Galanin-like peptide and ghrelin increase cytosolic Ca2+ in neurons containing growth hormone-releasing hormone in the arcuate nucleus

2005 ◽  
Vol 126 (1-2) ◽  
pp. 85-89 ◽  
Author(s):  
Motoki Kuramochi ◽  
Daisuke Kohno ◽  
Tatsushi Onaka ◽  
Satoshi Kato ◽  
Toshihiko Yada
Keyword(s):  
Growth Hormone ◽  
Arcuate Nucleus ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone
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