Differential Effects of Ketoconazole on Prolactin and Growth Hormone Release by Normal and Tumoral Rat Anterior Pituitary Cells in vitro

1989 ◽  
Vol 50 (5) ◽  
pp. 513-518 ◽  
Author(s):  
Robert Drouhault ◽  
Pierre Vacher ◽  
Jean P. David ◽  
Anne M. Courtes ◽  
Nidaravone Vilayleck ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Anterior Pituitary ◽  
Pituitary Cells ◽  
Hormone Release ◽  
Growth Hormone Release ◽  
Differential Effects ◽  
Anterior Pituitary Cells

GRF increases release of growth hormone and arachidonate from anterior pituitary cells

1985 ◽  
Vol 248 (4) ◽  
pp. E438-E442
Author(s):  
A. M. Judd ◽  
K. Koike ◽  
R. M. MacLeod
Keyword(s):  
Growth Hormone ◽  
Anterior Pituitary ◽  
Pituitary Cells ◽  
Dependent Manner ◽  
Hormone Release ◽  
Growth Hormone Release ◽  
Concentration Dependent Manner ◽  
Anterior Pituitary Cells ◽  
Arachidonate Release

Arachidonate and its metabolites increase growth hormone release in vitro. A study was designed to determine whether arachidonate release from anterior pituitary cells is modified by growth hormone-releasing factor (GRF) or somatostatin (SRIF). Cultured pituitary cells were incubated with [3H]arachidonate to esterify the long-chain fatty acid into cellular lipids. The cells were extensively washed with medium containing no [3H]arachidonate and then incubated with GRF and/or SRIF for 30 min. The incubation medium was then extracted with ethyl acetate, and following thin-layer chromatographic separation, the radioactivity in the [3H]arachidonate band was measured. GRF in a concentration-dependent manner (1-30 nM) stimulated growth hormone and arachidonate release, whereas SRIF (100 nM) blocked the GRF-induced increase of growth hormone and arachidonate release. The effects of GRF on growth hormone and arachidonate were evident at time intervals as brief as 5 min. These findings support the hypothesis that arachidonate may play a role in the GRF-induced growth hormone release.

Beta-Adrenergic Stimulation of Growth Hormone Release from Perifused Rat Anterior Pituitary Cells

1983 ◽  
Vol 37 (6) ◽  
pp. 473-475 ◽  
Author(s):  
Susan N. Perkins ◽  
William S. Evans ◽  
Michael O. Thorner ◽  
Michael.J. Cronin
Keyword(s):  
Growth Hormone ◽  
Anterior Pituitary ◽  
Pituitary Cells ◽  
Hormone Release ◽  
Growth Hormone Release ◽  
Adrenergic Stimulation ◽  
Beta Adrenergic ◽  
Anterior Pituitary Cells ◽  
Stimulation Of

Oligopeptides interfering with calcium channels inhibit prolactin and growth hormone release by cultured anterior pituitary cells of the rat

1990 ◽  
Vol 40 (4) ◽  
pp. 887-892 ◽  
Author(s):  
Iván Nagy ◽  
Gábor B. Makara ◽  
Vera Garamvölgyi ◽  
Sándor Bajusz ◽  
Erzsébet Széll ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Calcium Channels ◽  
Anterior Pituitary ◽  
Pituitary Cells ◽  
Hormone Release ◽  
Growth Hormone Release ◽  
Anterior Pituitary Cells
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