Interaction of Putative Endogenous Tryptolines with the Hypothalamic Serotonergic System and Prolactin Secretion in Adult Male Rats

1986 ◽  
Vol 43 (5) ◽  
pp. 603-610 ◽  
Author(s):  
A.Cecilia Rovescalli ◽  
Nicoletta Brunello ◽  
Cristina Franzetti ◽  
Giorgio Racagni
Keyword(s):  
Adult Male ◽  
Prolactin Secretion ◽  
Serotonergic System ◽  
Male Rats

Toxic effects of cadmium on the regulatory mechanism of dopamine and serotonin on prolactin secretion in adult male rats

2005 ◽  
Vol 155 (1) ◽  
pp. 87-96 ◽  
Author(s):  
A. Lafuente ◽  
A. González-Carracedo ◽  
A. Romero ◽  
T. Cabaleiro ◽  
A.I. Esquifino
Keyword(s):  
Adult Male ◽  
Regulatory Mechanism ◽  
Prolactin Secretion ◽  
Toxic Effects ◽  
Male Rats

Cadmium exposure disrupts GABA and taurine regulation of prolactin secretion in adult male rats

2009 ◽  
Vol 185 (3) ◽  
pp. 175-179 ◽  
Author(s):  
A. Caride ◽  
B. Fernández-Pérez ◽  
T. Cabaleiro ◽  
A.I. Esquifino ◽  
A. Lafuente
Keyword(s):  
Adult Male ◽  
Prolactin Secretion ◽  
Cadmium Exposure ◽  
Male Rats

Increased dopaminergic inhibition of prolactin in the hypoprolactinaemic IPL nude rat

1985 ◽  
Vol 107 (3) ◽  
pp. 325-329 ◽  
Author(s):  
H. Cohen ◽  
I. Sabbagh ◽  
P. Guillaumot ◽  
J. Bertrand
Keyword(s):  
Adult Male ◽  
Physiological Saline ◽  
Prolactin Secretion ◽  
Male Rats ◽  
Saline Control ◽  
Plasma Prolactin ◽  
Synthesis Inhibitor ◽  
Nude Rat ◽  
Prolactin Content ◽  
Pituitary Prolactin

ABSTRACT In this study, aimed at investigating whether dopaminergic regulation of prolactin could be implicated in the hypoprolactinaemia observed in the IPL nude rat, dopaminergic inhibition of prolactin was suppressed using a catecholamine synthesis inhibitor α-methyltyrosine (MT) and a dopaminergic antagonist sulpiride. Adult male rats (IPL nude and normal) were injected through implanted atrial cannulae with either MT (250 mg/kg) or physiological saline (control). Rats were decapitated 2 h after the injection. Plasma prolactin levels, compared with basal values, increased by 15·6 ± 1·9 (s.e.m.)- and 5·89 ± 0·6-fold in IPL nude and normal rats respectively. This difference was highly significant. The pituitary prolactin content was decreased in both groups. In a second experiment, adult male IPL nude or normal rats were injected with either sulpiride (1 mg/kg) or saline and decapitated 2, 4, 8, 12, 14 and 24 h later. Plasma prolactin levels, compared with basal values, were increased in rats injected with sulpiride by 9·2 ± 1·8 and 3·4 ± 0·7-fold in IPL nude and normal rats respectively. The pituitary prolactin content was reduced more in IPL nude than in normal sulpiride-injected rats. These data suggest that prolactin secretion, as well as synthesis, is under an increased dopaminergic inhibition in the male IPL nude rat. J. Endocr. (1985) 107, 325–329

Role of histamine in the increased secretion of prolactin induced by ether in adult male rats

1982 ◽  
Vol 95 (3) ◽  
pp. 409-415 ◽  
Author(s):  
E. O. Alvarez
Keyword(s):  
Adult Male ◽  
Third Ventricle ◽  
Prolactin Secretion ◽  
Histamine Receptors ◽  
Male Rats ◽  
Hypothalamic Area ◽  
Histamine Antagonists ◽  
The Third ◽  
Rostral Hypothalamus

The purpose of the present work was to determine the possible role of the histamine receptors located in the rostral zone of the hypothalamus in the control of the prolactin surge induced by ether stress. Cannulae were implanted into the preoptic anterior hypothalamic area or the third ventricle of several groups of adult male rats under ether anaesthesia. On the following day the rats were cannulated in the jugular vein so that they could be bled frequently. Twenty-four hours later saline, metiamide (an antagonist of H2 histamine) or pyrilamine (an antagonist of H1 histamine) were injected into the brain. Fifteen minutes after the injection all rats were subjected to an ether stress. Blood samples were taken at regular times after the stress and prolactin levels determined by radioimmunoassay. A prolactin surge was observed in rats injected with saline which extended up to 15–30 min after the stress. When the histamine antagonists were administered directly in the rostral hypothalamus both pyrilamine and metiamide inhibited the prolactin surge. When the histamine antagonists were administered into the third ventricle only metiamide was able to block the prolactin response completely. The present results suggest that histamine receptors in the rostral hypothalamus of the rat are involved in the control of prolactin secretion induced by stress.

Subchronic co-administration to cadmium, diazinon and selenium causes apparent symptoms of osteoporosis in adult male rats

2014 ◽  
Author(s):  
Radoslav Omelka ◽  
Hana Chovancova ◽  
Ivana Bobonova ◽  
Grzegorz Formicki ◽  
Robert Toman ◽  
...  
Keyword(s):  
Adult Male ◽  
Male Rats
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