Role of histamine in the increased secretion of prolactin induced by ether in adult male rats

1982 ◽  
Vol 95 (3) ◽  
pp. 409-415 ◽  
Author(s):  
E. O. Alvarez
Keyword(s):  
Adult Male ◽  
Third Ventricle ◽  
Prolactin Secretion ◽  
Histamine Receptors ◽  
Male Rats ◽  
Hypothalamic Area ◽  
Histamine Antagonists ◽  
The Third ◽  
Rostral Hypothalamus

The purpose of the present work was to determine the possible role of the histamine receptors located in the rostral zone of the hypothalamus in the control of the prolactin surge induced by ether stress. Cannulae were implanted into the preoptic anterior hypothalamic area or the third ventricle of several groups of adult male rats under ether anaesthesia. On the following day the rats were cannulated in the jugular vein so that they could be bled frequently. Twenty-four hours later saline, metiamide (an antagonist of H2 histamine) or pyrilamine (an antagonist of H1 histamine) were injected into the brain. Fifteen minutes after the injection all rats were subjected to an ether stress. Blood samples were taken at regular times after the stress and prolactin levels determined by radioimmunoassay. A prolactin surge was observed in rats injected with saline which extended up to 15–30 min after the stress. When the histamine antagonists were administered directly in the rostral hypothalamus both pyrilamine and metiamide inhibited the prolactin surge. When the histamine antagonists were administered into the third ventricle only metiamide was able to block the prolactin response completely. The present results suggest that histamine receptors in the rostral hypothalamus of the rat are involved in the control of prolactin secretion induced by stress.

Serotoninergic control of prolactin secretion in prepubertal male rats

1994 ◽  
Vol 131 (5) ◽  
pp. 547-554 ◽  
Author(s):  
Enrique Aguilar ◽  
Antonio Ranchal ◽  
Manuel Tena-Sempere ◽  
Leonor Pinilla
Keyword(s):  
Specific Inhibitor ◽  
Prolactin Secretion ◽  
Male Rats ◽  
Serotoninergic System ◽  
Selective Agonist ◽  
5 Ht Uptake ◽  
Releasing Effect

Aguilar E, Ranchal A, Tena-Sempere M, Pinilla L. Serotoninergic control of prolactin secretion in prepubertal male rats. Eur J Endocrinol 1994;131:547–54. ISSN 0804–4643 The role of the serotoninergic system in the control of prolactin (PRL) secretion has been studied in prepubertal male rats. Serum PRL concentration was measured in 16-day-old male rats at different times after the administration of 5-hydroxytryptophan (5-HTP), a precursor of serotonin (5-HT) synthesis, alone or in combination with fluoxetine, a specific inhibitor of 5-HT uptake; dl-p-parachlorophenylalanine (PCPA), an inhibitor of 5-HT synthesis; and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective agonist of 5-HT1A receptors. Also, serum PRL concentration and pituitary content were measured after 5-HTP administration in castrated males implanted with silastic capsules containing testosterone or 5α-androstane-3α,17β-diol (α-diol). We found that: the reduction in serotoninergic activity after PCPA administration did not modify serum PRL concentrations; the stimulatory effect of 5-HTP on PRL secretion was not observed before day 16; the effects of 5-HTP or 5-HTP and fluoxetine were similar in intact and orchidectomized males; a significant increase in PRL secretion took place after 8-OH-DPAT administration; the duration of the stimulatory effect of 5-HTP increased after α-diol treatment; and pituitary PRL content increased after 5-HTP injection in intact males and decreased in castrated males treated with testosterone or α-diol. Therefore, we conclude that: the PRL-releasing effect of 5-HTP remains after orchidectomy; activation of 5-HT1A receptors may mediate, at least partially, the effect of 5-HTP; testosterone and α-diol affect the duration of PRL release after 5-HTP administration differently; and testicular factors other than androgens might be involved in the effects of 5-HTP on PRL pituitary accumulation. Enrique Aguilar, Department of Physiology, Faculty of Medicine, Córdoba University, 14004 Córdoba, Spain

scholarly journals The Effect of Induced Diabetes Mellitus on the Cerebellar Cortex of Adult Male Rat and the Possible Protective Role of Oxymatrine: A Histological, Immunohistochemical and Biochemical Study

2021 ◽  
Author(s):  
Amany Mohamed Shalaby ◽  
Adel Mohamed Aboregela ◽  
Mohamed Ali Alabiad ◽  
Mona Tayssir Sadek
Keyword(s):  
Diabetes Mellitus ◽  
Purkinje Cells ◽  
Cerebellar Cortex ◽  
Adult Male ◽  
Protective Role ◽  
Diabetic Rats ◽  
Male Rats ◽  
Group I ◽  
Group Ii

Abstract Diabetes mellitus (DM) represents a widespread metabolic disease with a well-known neurotoxicity in both central and peripheral nervous systems. Oxymatrine is a traditional Chinese herbal medicine that has various pharmacological activities including; anti-oxidant, anti-apoptotic and anti-inflammatory potentials. The present work aimed to study the impact of diabetes mellitus on the cerebellar cortex of adult male albino rat and to evaluate the potential protective role of oxymatrine using different histological methods. Fifty-five adult male rats were randomly divided into three groups: group I served as control, group II was given oxymatrine (80 mg/kg/day) orally for 8 weeks and group III was given a single dose of streptozotocin (50mg/kg) intaperitoneally to induce diabetes. Then diabetic rats were subdivided into two subgroups: subgroup IIIa that received no additional treatment and subgroup IIIb that received oxymatrine similar to group II. The diabetic group revealed numerous changes in the Purkinje cell layer in the form of multilayer arrangement of Purkinje cells, shrunken cells with deeply stained nuclei as well as focal loss of the Purkinje cells. A significant increment in GFAP and synaptophysin expression was reported. Transmission electron microscopy showed irregularity and splitting of myelin sheaths in the molecular layer, dark shrunken Purkinje cells with ill-defined nuclei, dilated Golgi saccules and dense granule cells with irregular nuclear outlines in the granular layer. In contrast, these changes were less evident in diabetic rats that received oxymatrine. In conclusion, Oxymatrine could protect the cerebellar cortex against changes induced by DM.

Endoscopic Resection of Hemorrhaged Third Ventricle Cavernous Malformation: 2-Dimensional Operative Video

2018 ◽  
Vol 16 (2) ◽  
pp. E51-E51
Author(s):  
Giorgio Palandri ◽  
Thomas Sorenson ◽  
Mino Zucchelli ◽  
Nicola Acciarri ◽  
Paolo Mantovani ◽  
...  
Keyword(s):  
Gold Standard ◽  
Intraventricular Hemorrhage ◽  
Cavernous Malformation ◽  
Third Ventricle ◽  
Gross Total Resection ◽  
Vascular Lesions ◽  
Total Resection ◽  
Cavernous Malformations ◽  
The Third

Abstract Cavernous malformations of the third ventricle are uncommon vascular lesions. Evidence suggests that cavernous malformations in this location might have a more aggressive natural history due to their risk of intraventricular hemorrhage and hydrocephalus.1 The gold standard of treatment is considered to be microsurgical gross total resection of the lesion. However, with progressive improvement in endoscopic capabilities, several authors have recently advocated for the role of minimally-invasive neuroendoscopy for resecting intraventricular cavernous malformations.2-4 In this timely intraoperative video, we demonstrate the gross total resection of a third ventricle cavernous malformation that presented with hemorrhage via a right-sided trans-frontal neuroendoscopic approach.

THE ROLE OF ALKALINE PHOSPHATASE IN INTESTINAL ABSORPTION: IV. THE EFFECTS OF VARIOUS PROTEINS ON LEVELS OF THE ENZYME IN INTESTINAL MUCOSA

1955 ◽  
Vol 33 (1) ◽  
pp. 89-92 ◽  
Author(s):  
Jules Tuba ◽  
Nester Dickie
Keyword(s):  
Alkaline Phosphatase ◽  
Intestinal Absorption ◽  
Intestinal Mucosa ◽  
Adult Male ◽  
Wheat Gluten ◽  
Male Rats ◽  
Dietary Proteins ◽  
Intestinal Alkaline Phosphatase ◽  
Egg Albumin

Fasted adult male rats were used to study the effect of dietary proteins on intestinal alkaline phosphatase. Groups of animals were offered one of several proteins; lactalbumin, egg albumin, zein, gelatin, wheat gluten, casein, and vitellin. Control animals had cellulose fed to them. The rats were sacrificed six hours after they were given the different diets. Alkaline phosphatase determinations with intestinal homogenates indicated that the two phosphoproteins, casein and vitellin, elevated levels of the enzyme significantly above fasting levels. Possible interpretations of these findings are discussed.

Role of Quercetin on PCBs (Aroclor-1254) Induced Impairment of Dopaminergic Receptor mRNA Expression in Cerebral Cortex of Adult Male Rats

2011 ◽  
Vol 36 (8) ◽  
pp. 1344-1352 ◽  
Author(s):  
Rasiah Pratheepa Kumari ◽  
Kandaswamy Selvakumar ◽  
Senthamilselvan Bavithra ◽  
Rafiq Zumaana ◽  
Gunasekaran Krishnamoorthy ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Mrna Expression ◽  
Adult Male ◽  
Male Rats ◽  
Aroclor 1254 ◽  
Dopaminergic Receptor ◽  
Receptor Mrna

Somatostatin Inhibits prolactin secretion in the estradiol primed male rat

1981 ◽  
Vol 59 (10) ◽  
pp. 1082-1088 ◽  
Author(s):  
G. R. Cooper ◽  
S. H. Shin
Keyword(s):  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Blocking Agent ◽  
Prolactin Secretion ◽  
Male Rats ◽  
Male Rat ◽  
Dependent Manner ◽  
Intact Male ◽  
Plasma Prl

Somatostatin inhibits not only growth hormone secretion, but also the secretion of several other hormones. The role of somatostatin in prolactin (PRL) secretion has not been clearly demonstrated. The present study was undertaken to examine the effects of somatostatin on rat PRL secretion in several different circumstances where the circulating PRL level is elevated: (1) the estradiol primed intact male rat, (2) normal and (3) estradiol primed rats pretreated with pimozide, (4) normal and (5) estradiol primed hypophysectomized male rats with adenohypophyses grafted under the kidney capsule (HAG rat). Blood samples (70 μL) were taken every 2 min via an indwelling atrial cannula from conscious, unrestrained animals. In the estradiol primed intact rats, a bolus injection of somatostatin (10, 100, and 1000 μg/kg) lowered PRL levels in a dose-dependent manner. When the PRL concentration was elevated by the administration of pimozide (3 mg/kg), a dopaminergic receptor blocking agent, somatostatin was ineffective in decreasing plasma PRL concentration but the PRL concentration was lowered by somatostatin when the rat had been primed with estradiol. Somatostatin had no effect on the normal HAG rats, but lowered the plasma PRL concentration in the estradiol primed HAG rats. Since somatostatin inhibits PRL secretion only in the estradiol primed rats, it is suggested that estradiol priming creates a new environment, presumably via new or altered receptors, which can be inhibited by somatostatin.

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