Stimulation of Growth Hormone Release by Vasoactive Intestinal Peptide and Peptide PHI in Rat Anterior Pituitary Reaggregates

1985 ◽  
Vol 40 (1) ◽  
pp. 88-91 ◽  
Author(s):  
Carl Denef ◽  
Carla Schramme ◽  
Myriam Baes
1974 ◽  
Vol 142 (2) ◽  
pp. 295-300 ◽  
Author(s):  
J. George Schofield ◽  
Margaret McPherson

The release of growth hormone from heifer anterior pituitary slices and the cyclic AMP content of the slices were increased by the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine, both increases being related to inhibitor concentration over the range 0.1–1.0mm. Neither Ba2+(6.9 or 2.3mm), K+(72mm), nor p-chloromercuribenzoate (20μm) had any effect on pituitary cyclic AMP content over a 20min period. 3-Isobutyl-1-methylxanthine potentiated the release of growth hormone in response to Ba2+(2.3mm) and K+(24mm), but the degree of potentiation did not depend on inhibitor concentration in the same way as did tissue cyclic AMP content. 3-Isobutyl-1-methylxanthine decreased the concentration of K+required to give maximum stimulation of growth-hormone release, but did not significantly increase the maximum response to Ba2+. Growth-hormone release in the presence of prostaglandin E2 (1μm) was increased by 3-isobutyl-1-methylxanthine and was inhibited by the prostaglandin antagonist, 7-oxa-13-prostynoic acid, although this antagonist increased the pituitary cyclic AMP concentration and potentiated the prostaglandin E2-induced rise in cyclic AMP content. The stimulation of growth-hormone release by p-chloromercuribenzoate was not potentiated by 3-isobutyl-1-methylxanthine. The data suggest that Ba+and K+act at the same point in the secretory process as 3-isobutyl-1-methylxanthine, although by a different mechanism, and that p-chloromercuribenzoate has a different point of action.


1983 ◽  
Vol 37 (6) ◽  
pp. 473-475 ◽  
Author(s):  
Susan N. Perkins ◽  
William S. Evans ◽  
Michael O. Thorner ◽  
Michael.J. Cronin

Endocrinology ◽  
1986 ◽  
Vol 119 (5) ◽  
pp. 2004-2011 ◽  
Author(s):  
JACQUES SIMARD ◽  
JEAN-FRANÇOIS HUBERT ◽  
TEANOOSH HOSSEINZADEH ◽  
FERNAND LABRIE

Endocrinology ◽  
1972 ◽  
Vol 90 (5) ◽  
pp. 1315-1319 ◽  
Author(s):  
JUERGEN SANDOW ◽  
AKIRA ARIMURA ◽  
ANDREW V. SCHALLY

1981 ◽  
Vol 32 (4) ◽  
pp. 213-216 ◽  
Author(s):  
Carlo Ferrari ◽  
Roberto Caldara ◽  
Cristiano Barbieri ◽  
Paolo Testori ◽  
Rosanna Benco ◽  
...  

2017 ◽  
Vol 8 (6) ◽  
pp. 2110-2114 ◽  
Author(s):  
Yee Yin Ho ◽  
Junya Nakato ◽  
Takafumi Mizushige ◽  
Ryuhei Kanamoto ◽  
Mamoru Tanida ◽  
...  

Stimulation of growth hormone release induced by intraduodenally administered l-ornithine was mediated by the ghrelin system in rats.


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