Compensatory Adrenal Growth in Immature and Mature Male Rats

1980 ◽  
Vol 31 (1) ◽  
pp. 34-38 ◽  
Author(s):  
Matilde A. Holzwarth ◽  
Charles W. Wilkinson ◽  
Mary F. Dallman
Keyword(s):  
Mature Male ◽  
Male Rats

scholarly journals Immunohistochemical localization of melatonin in the rat Harderian gland.

1976 ◽  
Vol 24 (11) ◽  
pp. 1173-1177 ◽  
Author(s):  
G A Bubenik ◽  
G M Brown ◽  
L J Grota
Keyword(s):  
Acinar Cells ◽  
Harderian Gland ◽  
Immunohistochemical Localization ◽  
Mature Male ◽  
Male Rats ◽  
Secretory Cells ◽  
Yellow Fluorescence ◽  
Double Antibody

Using fluorescence and double antibody techniques, melatonin was localized immunohistologically in the secretory cells of the Harderian gland of mature male rats. The presence and quantity of melatonin in the acinar cells seem to correlate with the amount of porphyrins inside the lumen. The specificity was proven by disappearance of yellow fluorescence after saturation of antibody with melatonin or after use of nonspecific antibody only.

Effects of Dietary Calcium upon Lipid Metabolism in Mature Male Rats Fed Beef Tallow

1966 ◽  
Vol 88 (3) ◽  
pp. 255-260 ◽  
Author(s):  
A. I. Fleischman ◽  
H. Yacowitz ◽  
T. Hayton ◽  
M. L. Bierenbaum
Keyword(s):  
Lipid Metabolism ◽  
Beef Tallow ◽  
Dietary Calcium ◽  
Mature Male ◽  
Male Rats

INFLUENCE OF SEX HORMONES ON AMIDINOTRANSFERASE LEVELS. METABOLIC CONTROL OF CREATINE BIOSYNTHESIS

1966 ◽  
Vol 53 (4) ◽  
pp. 655-662 ◽  
Author(s):  
István Kriskó ◽  
James B. Walker
Keyword(s):  
Testosterone Propionate ◽  
De Novo ◽  
Specific Activity ◽  
Hormonal Control ◽  
Mature Male ◽  
Female Rats ◽  
Male Rats ◽  
Enzyme Protein ◽  
Wet Weight ◽  
Mammalian Enzyme

ABSTRACT Arginine: glycine amidinotransferase is the first of two enzymes involved in creatine biosynthesis. The amidinotransferase specific activity (micromoles of hydroxyguanidine formed per hour per g wet weight of tissue) of kidney homogenates of mature male rats was about twice that of females of the same age, whereas activities were equal before puberty. Castration decreased the activity of males and increased that of females. The administration of testosterone propionate to young adult female rats resulted in a significant increase in enzyme activity. The same enzyme had previously been shown to be repressible by its end-product, creatine. Although there are numerous enzymes whose synthesis is known to be under hormonal control, amidinotransferase is the only mammalian enzyme described up to now on which there appears to operate both an end-product repression mechanism and a hormonal control on the de novo synthesis of the enzyme protein.

Initial induction and subsequent reduction of α2u-globulin in urine and serum of mature male rats after repeated intraperitoneal injections of (anti)estrogen

Toxicology ◽  
2001 ◽  
Vol 162 (2) ◽  
pp. 73-80 ◽  
Author(s):  
Hirohisa Nagahori ◽  
Koichiro Komai ◽  
Yoshitaka Tomigahara ◽  
Koichi Saito ◽  
Naohiko Isobe ◽  
...  
Keyword(s):  
Mature Male ◽  
Male Rats ◽  
Subsequent Reduction ◽  
Urine And Serum

THE EFFECTS OF TESTOSTERONE AND ITS 5α-REDUCED METABOLITES ON PITUITARY RESPONSIVENESS TO GONADOTROPHIN-RELEASING HORMONE (Gn-RH)

1977 ◽  
Vol 86 (4) ◽  
pp. 728-732 ◽  
Author(s):  
Y. Epstein ◽  
B. Lunenfeld ◽  
Z. Kraiem
Keyword(s):  
Pituitary Gland ◽  
Mature Male ◽  
Male Rats ◽  
Releasing Hormone ◽  
Gonadotrophin Releasing Hormone ◽  
Low Levels ◽  
High Doses ◽  
Dose Dependent ◽  
Stimulation Of

ABSTRACT The aim of this study was to investigate effects of androgens on gonadotrophin release in response to gonadotrophin-releasing hormone (Gn-RH) stimulation in vitro. Hemipituitaries of mature male rats were pre-incubated for 90 min with T, DHT, 3α- or 3β-diol (4 ng or 4 μg/ml medium), and the incubation continued for 240 min after adding Gn-RH (1 ng/ml medium). Gn-RH caused a 4-5-fold rise in the secretion of LH and a 2-fold rise in FSH secretion. The effect of the androgens was dose-dependent. At low levels, T and DHT exerted no effect on Gn-RH-stimulated gonadotrophin release, whereas the two androstanediols (3α- and 3β-diol) augmented the Gn-RH stimulation of both gonadotrophins, though preferentially LH. With high doses of androgens, the results obtained showed: a) no effect of T; b) DHT suppression of the Gn-RH-stimulated FSH release; c) suppression of Gn-RH stimulation by 3α- and 3β-diol regarding both LH and FSH. It is concluded that T exerts through its reduced metabolites a feedback effect on the pituitary gland responsiveness to Gn-RH stimulation.

Sperm protamine levels as indicators of fertilising potential in sexually mature male rats

Andrologia ◽  
2008 ◽  
Vol 40 (1) ◽  
pp. 29-37 ◽  
Author(s):  
M. Aleem ◽  
V. Padwal ◽  
J. Choudhari ◽  
N. Balasinor ◽  
M. K. Gill-Sharma
Keyword(s):  
Mature Male ◽  
Male Rats ◽  
Sexually Mature

scholarly journals Fenoterol did not enhance glucocorticoid-induced skeletal changes in male rats.

2011 ◽  
Vol 58 (3) ◽  
Author(s):  
Joanna Folwarczna ◽  
Barbara Nowińska ◽  
Leszek Śliwiński ◽  
Maria Pytlik ◽  
Urszula Cegieła ◽  
...  
Keyword(s):  
Mature Male ◽  
Male Rats ◽  
Femoral Diaphysis ◽  
Skeletal System ◽  
Concurrent Administration ◽  
Skeletal Changes ◽  
Bone Changes ◽  
Male Wistar Rats ◽  
Turnover Markers ◽  
Fenoterol Hydrobromide

Glucocorticoids and β(2)-adrenergic receptor agonists are the most commonly used drugs in the treatment of asthma. Both therapies are potentially dangerous to the skeletal system. The aim of the present study was to investigate the effects of fenoterol, a β(2)-receptor agonist, on the development of bone changes induced by glucocorticoid (prednisolone) administration in mature male rats. The experiments were carried out on 24-week-old male Wistar rats. The effects of prednisolone 21-hemisuccinate sodium salt (7 mg/kg s.c. daily) or/and fenoterol hydrobromide (1.4 mg/kg i.p. daily), administered for 4 weeks, on the skeletal system were studied. Bone turnover markers, geometric parameters, mass, mass of bone mineral in the tibia, femur and L-4 vertebra, bone histomorphometric parameters and mechanical properties of tibial metaphysis, femoral diaphysis and femoral neck were determined. Both prednisolone and fenoterol had damaging effects on the skeletal system of mature male rats. However, concurrent administration of fenoterol and prednisolone did not result in the intensification of the deleterious skeletal effect of either drug administered separately.

scholarly journals The Effect of Diabetes on the Physiological Parameters in Male Rats

2020 ◽  
Vol 13 (1) ◽  
pp. 66-73
Author(s):  
Ziadoon mukhlif ◽  
Saleh Rahim ◽  
Mustafa jamal
Keyword(s):  
Mature Male ◽  
Male Rats ◽  
Control Group ◽  
Distilled Water ◽  
High Blood Glucose ◽  
Blood Samples ◽  
Physiological Conditions ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Body Production

The aim of this study is to assess the effects of high blood glucose levels in male rats with diabetic induced by alloxan on their physiological conditions. Diabetes mellitus is a category of metabolic hyperglycemia disorders caused by insufficient body production or pancreatic action. In addition to hyperglycemia, a number of other factors are also important for pathogenesis, such as Hyperlipidemics and cortisol oxidative. Forty five mature male rats used in this study, these were divided into 3 groups, Control group(G1) : gavage distilled water, Group2(G2): injection intraperitoneally with Alloxan150 mg/kg bw for two weeks and Group3(G3): injection intraperitoneally with Alloxan 150mg/kg bw for twenty four days. Blood samples taken from all groups estimation of Peroxynitrate, GSH, CAT, and SOD concentrations%. The findings revealed a significant improvement in diabetic classes in glucose (p<0.05) and peroxynitrate relative to control (G1). Diabetic concentrations of (G2, G3) relative to the control group (G1) were substantially reduced in SOD, GSH, CAT and diabetes mediated (P < 0,05). In conclusion, diabetes can cause significant changes in SOD, GSH, CAT levels in rats.

Effect of resistance exercise training on cortical and cancellous bone in mature male rats

1998 ◽  
Vol 84 (2) ◽  
pp. 459-464 ◽  
Author(s):  
Kim C. Westerlind ◽  
James D. Fluckey ◽  
Scott E. Gordon ◽  
William J. Kraemer ◽  
Peter A. Farrell ◽  
...  
Keyword(s):  
Resistance Training ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Cortical Bone ◽  
Cancellous Bone ◽  
Mature Male ◽  
Male Rats ◽  
Northern Analysis ◽  
Bone Area ◽  
Resistance Exercise Training

Westerlind, Kim C., James D. Fluckey, Scott E. Gordon, William J. Kraemer, Peter A. Farrell, and Russell T. Turner.Effect of resistance exercise training on cortical and cancellous bone in mature male rats. J. Appl. Physiol. 84(2): 459–464, 1998.—The effect of resistance training on tibial cancellous and cortical bone was evaluated in rats by using static histomorphometry and Northern analysis. Five-month-old male Sprague-Dawley rats were randomly assigned to exercise (Ex; n = 8) or control (Con; n = 4) groups. Animals were operantly conditioned to press two levers, facilitating full extension and flexion of the hindlimbs (“squats”), while wearing an unweighted vest. After an 8-wk familiarization period, Ex animals performed 3 sessions/wk for 17–19 sessions with progressively increased amounts of weight applied to the vest. Con rats completed the same exercise protocol without applied resistance. No difference in cross-sectional, medullary, or cortical bone area was observed between Ex and Con rats in the tibial diaphysis. In contrast, the cancellous bone area in the proximal tibial metaphysis was significantly larger in trained rats. Trabecular number, trabecular thickness, and the percentage of cancellous bone covered by osteoid were significantly greater in the Ex animals compared with Con animals. In addition, steady-state mRNA levels for osteocalcin for the Ex group were 456% those expressed in the Con group. The data demonstrate that resistance training increases cancellous bone area in sexually mature male rats and suggest that it does so, in part, by stimulating bone formation.

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