Evidence for an Inhibitory Dopaminergic and Stimulatory Noradrenergic Hypothalamic Influence on PMS-Induced Ovulation in the Immature Rat. II. A Pharmacological Analysis

1977 ◽  
Vol 24 (5-6) ◽  
pp. 289-316 ◽  
Author(s):  
A. Löfström ◽  
L.F. Agnati ◽  
K. Fuxe ◽  
T. Hökfelt
Keyword(s):  
Immature Rat ◽  
Induced Ovulation ◽  
Pharmacological Analysis ◽  
Hypothalamic Influence

Ovarian increase in kinin-generating capacity in PMSG/hCG-primed immature rat

1986 ◽  
Vol 251 (3) ◽  
pp. E362-E365 ◽  
Author(s):  
L. L. Espey ◽  
D. H. Miller ◽  
H. S. Margolius
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Wistar Rats ◽  
Immature Rat ◽  
Induced Ovulation ◽  
Generating Capacity ◽  
Phosphate Buffered Saline ◽  
Ovulatory Process

Ovarian kinin-generating capacity was determined during induced ovulation in immature Wistar rats. The onset of ovulation was monitored by counting the number of ova in the oviducts at 2-h intervals after the administration of human chorionic gonadotropin (hCG). Ova began to appear in significant numbers at 14 h after hCG, with an average of 7.6 +/- 2.3 ova/rat. By 16 h after hCG, the oviducts contained 32.7 +/- 4.1 ova/rat. The ovaries from each group of animals were homogenized in phosphate-buffered saline, and extracts of this tissue were incubated for 200 min to allow the generation of kinins from endogenous kininogen. The amount of kinin generated by this procedure was measured by radioimmunoassay. At 0 h (i.e., just before the administration of hCG), the ovaries contained 5.90 +/- 0.60 pg kinin/micrograms protein per 200 min in the ovarian extract. By 4 h after hCG, the kinins increased significantly (P less than 0.05) to 13.16 +/- 3.61 pg kinin/micrograms protein. The kinins progressively increased (P less than 0.001) to 67.88 +/- 23.26 pg kinin/micrograms protein by 16 h after hCG. Indomethacin and cycloheximide significantly inhibited both kinin-generating activity and ovulation. These data suggest that kinin-forming activity and kinins may have a role in the ovulatory process of mammals.

scholarly journals Pharmacological analysis of the CCKB/gastrin receptors mediating pentagastrin-stimulated gastric acid secretion in the isolated stomach of the immature rat

1996 ◽  
Vol 119 (7) ◽  
pp. 1401-1410 ◽  
Author(s):  
David M. Hills ◽  
V. Paul Gerskowitch ◽  
Sonia P. Roberts ◽  
Nicola J. Welsh ◽  
Nigel P. Shankley ◽  
...  
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Immature Rat ◽  
Pharmacological Analysis

PMS-Induced Ovulation in the Immature Rat Following Unilateral Castration

1965 ◽  
Vol 119 (2) ◽  
pp. 331-334 ◽  
Author(s):  
M. X. Zarrow ◽  
S. K. Sundaram ◽  
M. Stob
Keyword(s):  
Immature Rat ◽  
Induced Ovulation

The involvement of serotonin in induced ovulation in the immature rat

1979 ◽  
Vol 35 (5) ◽  
pp. 692-694 ◽  
Author(s):  
V. D. Parker ◽  
K. F. A. Soliman ◽  
C. A. Walker
Keyword(s):  
Immature Rat ◽  
Induced Ovulation

Action of Progesterone on PMS-Induced Ovulation in the Immature Rat

Endocrinology ◽  
1969 ◽  
Vol 84 (5) ◽  
pp. 1274-1276 ◽  
Author(s):  
M. X. ZARROW ◽  
R. V. GALLO
Keyword(s):  
Immature Rat ◽  
Induced Ovulation

Inhibition of Pregnant Mare’s Serum-Induced Ovulation in the Immature Rat

Endocrinology ◽  
1964 ◽  
Vol 74 (3) ◽  
pp. 309-313 ◽  
Author(s):  
DAVID L. QUINN ◽  
M. X. ZARROW
Keyword(s):  
Immature Rat ◽  
Induced Ovulation

SUPEROVULATION IN THE IMMATURE RAT FOLLOWING TREATMENT WITH PMS ALONE AND INHIBITION OF PMS-INDUCED OVULATION

1963 ◽  
Vol 26 (2) ◽  
pp. 181-188 ◽  
Author(s):  
M. X. ZARROW ◽  
D. L. QUINN
Keyword(s):  
Pituitary Gland ◽  
Average Response ◽  
Immature Rat ◽  
Induced Ovulation ◽  
Ovulation Inhibition ◽  
Average Maximum ◽  
Endogenous Release ◽  
Marked Drop

SUMMARY Superovulation can be induced in the immature rat by PMS alone or PMS followed by HCG. Treatment with PMS alone caused an initial average response of 2·8 ova at an age of 20 days and a maximum average response of 70·8 ova at age 28. Treatment with PMS and HCG resulted in an initial average response of 0·3 ova at age 18 days and an average maximum of 61 ova at 22 days of age. A marked drop to approximately 8–10 ova was noted at 45 days of age following both types of treatment. Hypophysectomy revealed that the pituitary gland was necessary for the release of ova following injection of PMS alone. Removal of the pituitary gland as late as 52 hr. after injection of PMS prevented ovulation. Inhibition of ovulation by treatment with dibenamine, SKF-501, atropine and 'Nembutal' following injection of PMS alone led to the concept that superovulation following PMS involves a neural link that is responsible for the endogenous release of LH.

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