The Effect of Testosterone and Other Adrenal Steroids on PMS-Induced Ovulation in the Immature Rat

1975 ◽  
Vol 17 (1) ◽  
pp. 27-39 ◽  
Author(s):  
N. Hagino ◽  
J.W. Goldzieher
Keyword(s):  
Adrenal Steroids ◽  
Immature Rat ◽  
Induced Ovulation

Ovarian increase in kinin-generating capacity in PMSG/hCG-primed immature rat

1986 ◽  
Vol 251 (3) ◽  
pp. E362-E365 ◽  
Author(s):  
L. L. Espey ◽  
D. H. Miller ◽  
H. S. Margolius
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Wistar Rats ◽  
Immature Rat ◽  
Induced Ovulation ◽  
Generating Capacity ◽  
Phosphate Buffered Saline ◽  
Ovulatory Process

Ovarian kinin-generating capacity was determined during induced ovulation in immature Wistar rats. The onset of ovulation was monitored by counting the number of ova in the oviducts at 2-h intervals after the administration of human chorionic gonadotropin (hCG). Ova began to appear in significant numbers at 14 h after hCG, with an average of 7.6 +/- 2.3 ova/rat. By 16 h after hCG, the oviducts contained 32.7 +/- 4.1 ova/rat. The ovaries from each group of animals were homogenized in phosphate-buffered saline, and extracts of this tissue were incubated for 200 min to allow the generation of kinins from endogenous kininogen. The amount of kinin generated by this procedure was measured by radioimmunoassay. At 0 h (i.e., just before the administration of hCG), the ovaries contained 5.90 +/- 0.60 pg kinin/micrograms protein per 200 min in the ovarian extract. By 4 h after hCG, the kinins increased significantly (P less than 0.05) to 13.16 +/- 3.61 pg kinin/micrograms protein. The kinins progressively increased (P less than 0.001) to 67.88 +/- 23.26 pg kinin/micrograms protein by 16 h after hCG. Indomethacin and cycloheximide significantly inhibited both kinin-generating activity and ovulation. These data suggest that kinin-forming activity and kinins may have a role in the ovulatory process of mammals.

PMS-Induced Ovulation in the Immature Rat Following Unilateral Castration

1965 ◽  
Vol 119 (2) ◽  
pp. 331-334 ◽  
Author(s):  
M. X. Zarrow ◽  
S. K. Sundaram ◽  
M. Stob
Keyword(s):  
Immature Rat ◽  
Induced Ovulation

The involvement of serotonin in induced ovulation in the immature rat

1979 ◽  
Vol 35 (5) ◽  
pp. 692-694 ◽  
Author(s):  
V. D. Parker ◽  
K. F. A. Soliman ◽  
C. A. Walker
Keyword(s):  
Immature Rat ◽  
Induced Ovulation

Action of Progesterone on PMS-Induced Ovulation in the Immature Rat

Endocrinology ◽  
1969 ◽  
Vol 84 (5) ◽  
pp. 1274-1276 ◽  
Author(s):  
M. X. ZARROW ◽  
R. V. GALLO
Keyword(s):  
Immature Rat ◽  
Induced Ovulation

Inhibition of Pregnant Mare’s Serum-Induced Ovulation in the Immature Rat

Endocrinology ◽  
1964 ◽  
Vol 74 (3) ◽  
pp. 309-313 ◽  
Author(s):  
DAVID L. QUINN ◽  
M. X. ZARROW
Keyword(s):  
Immature Rat ◽  
Induced Ovulation

SUPEROVULATION IN THE IMMATURE RAT FOLLOWING TREATMENT WITH PMS ALONE AND INHIBITION OF PMS-INDUCED OVULATION

1963 ◽  
Vol 26 (2) ◽  
pp. 181-188 ◽  
Author(s):  
M. X. ZARROW ◽  
D. L. QUINN
Keyword(s):  
Pituitary Gland ◽  
Average Response ◽  
Immature Rat ◽  
Induced Ovulation ◽  
Ovulation Inhibition ◽  
Average Maximum ◽  
Endogenous Release ◽  
Marked Drop

SUMMARY Superovulation can be induced in the immature rat by PMS alone or PMS followed by HCG. Treatment with PMS alone caused an initial average response of 2·8 ova at an age of 20 days and a maximum average response of 70·8 ova at age 28. Treatment with PMS and HCG resulted in an initial average response of 0·3 ova at age 18 days and an average maximum of 61 ova at 22 days of age. A marked drop to approximately 8–10 ova was noted at 45 days of age following both types of treatment. Hypophysectomy revealed that the pituitary gland was necessary for the release of ova following injection of PMS alone. Removal of the pituitary gland as late as 52 hr. after injection of PMS prevented ovulation. Inhibition of ovulation by treatment with dibenamine, SKF-501, atropine and 'Nembutal' following injection of PMS alone led to the concept that superovulation following PMS involves a neural link that is responsible for the endogenous release of LH.

Effect of Progesterone and Other Steroids on PMS-Induced Ovulation in the Immature Rat

Endocrinology ◽  
1970 ◽  
Vol 86 (2) ◽  
pp. 296-304 ◽  
Author(s):  
R. V. GALLO ◽  
M. X. ZARROW
Keyword(s):  
Immature Rat ◽  
Induced Ovulation

EFFECT OF CATECHOL OESTROGENS ON INDUCED OVULATION IN THE IMMATURE RAT

1980 ◽  
Vol 86 (2) ◽  
pp. 263-268 ◽  
Author(s):  
S. FRANKS ◽  
P. BALL ◽  
F. NAFTOLIN ◽  
K. B. RUF
Keyword(s):  
Positive Feedback ◽  
Physiological Role ◽  
Fallopian Tubes ◽  
Minimum Effective Dose ◽  
Sprague Dawley ◽  
Immature Rat ◽  
Induced Ovulation ◽  
Sprague Dawley Rats ◽  
Pregnant Mare Serum Gonadotrophin ◽  
Positive Feedback Effect

The 'positive feedback' effect of exogenous oestradiol-17β in advancing ovulation induced by pregnant mare serum gonadotrophin (PMSG) has been used in the present study as a model in which to test the possible oestrogenic or antioestrogenic effects of the catechol oestrogens, 2-hydroxyoestradiol (2-OHE2) and 4-OHE2. Sprague–Dawley rats of 26 days of age were injected with 20 i.u. PMSG together with either vehicle alone or test steroids. The animals were killed 72 h later and the Fallopian tubes were examined for the presence of ova. Advancement of induced ovulation by treatment with oestradiol was confirmed; 2-OHE2, in doses of up to 100 pg, influenced neither the time of ovulation nor the number of ova present but 4-OHE2 was equipotent with oestradiol in doses varying from 0·5 pg (the minimum effective dose for both steroids) to 10 μg. The possible antioestrogenic effect of 2-OHE2 was tested by giving a 100 pg dose either at the same time or 2 h before PMSG plus 2 pg oestradiol or 4-OHE2. The effects of oestradiol and 4-OHE2 were not altered by this treatment. These data show that, in this model of'positive feedback', 2-OHE2 has neither an oestrogenic nor an antioestrogenic action but that 4-OHE2 has a potent oestrogenic action, thus raising the question of a physiological role for 4-OHE2 in the regulation of ovulation.

An early single dose of progesterone agonist attenuates endogenous progesterone surge and reduces ovulation rate in immature rat model of induced ovulation

Steroids ◽  
2011 ◽  
Vol 76 (10-11) ◽  
pp. 1116-1125 ◽  
Author(s):  
Tadatsugu Abe ◽  
Daisuke Toida ◽  
Hironori Satoh ◽  
Tomohiro Yonezawa ◽  
Mitsumori Kawaminami ◽  
...  
Keyword(s):  
Single Dose ◽  
Rat Model ◽  
Ovulation Rate ◽  
Immature Rat ◽  
Induced Ovulation
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