Plasma Cortisol, Catecholamine and Cyclic AMP Levels, Response to Dexamethasone Suppression Test and Platelet MAO Activity in Manic-Depressive Patients

1984 ◽  
Vol 11 (3) ◽  
pp. 168-173 ◽  
Author(s):  
Mario Maj ◽  
Grazia Ariano ◽  
Francesco Arena ◽  
Dargut Kemali
Keyword(s):  
Cyclic Amp ◽  
Plasma Cortisol ◽  
Dexamethasone Suppression Test ◽  
Manic Depressive ◽  
Platelet Mao ◽  
Mao Activity ◽  
Platelet Mao Activity ◽  
Suppression Test ◽  
Depressive Patients ◽  
Dexamethasone Suppression

Platelet Monoamine Oxidase in Schizophrenia and Manic-Depressive Illness

1976 ◽  
Vol 129 (3) ◽  
pp. 227-232 ◽  
Author(s):  
Robert H. Belmaker ◽  
Kirsten Ebbesen ◽  
Richard Ebstein ◽  
Ranan Rimon
Keyword(s):  
Monoamine Oxidase ◽  
Health Centre ◽  
Depressive Illness ◽  
Manic Depressive Illness ◽  
Manic Depressive ◽  
Platelet Mao ◽  
Schizophrenic Patients ◽  
Mao Activity ◽  
Platelet Mao Activity ◽  
Depressive Patients

SummaryMonoamine oxidase (MAO) is an important enzyme in the catabolism of brain biogenic amines. Platelet MAO has been reported to be moderately reduced in manic-depressive patients and markedly reduced in schizophrenic patients. This enzyme's activity has been shown to be under a large degree of genetic control and has been proposed as a ‘genetic marker’ in schizophrenia. A transcultural replication of the finding of low platelet MAO in schizophrenia and manic-depressive illness was carried out at the Jerusalem Mental Health Centre. Manic-depressive patients were found to have higher platelet MAO activity than schizophrenic patients, as reported previously, but control individuals were as low as the schizophrenic patients. It is unlikely that platelet MAO activity is a transculturally-valid marker for schizophrenia.

Postdexamethason intact and multisequentia ACTH in melancholia

1991 ◽  
Vol 3 (1) ◽  
pp. 8-13
Author(s):  
M. Maes ◽  
C. Vandervorst ◽  
E. Suy ◽  
M. Martin ◽  
B. Minner ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Plasma Levels ◽  
Clinical Relevance ◽  
Plasma Cortisol ◽  
Adrenocorticotropic Hormone ◽  
Severity Of Illness ◽  
Dexamethasone Suppression Test ◽  
Before And After ◽  
Suppression Test ◽  
Dexamethasone Suppression

SummaryThe dexamethasone suppression test has been carried out in 111 depressed inpatients. Fasting, 8 a.m. plasma levels of Cortisol and adrenocorticotropic hormone (ACTH) were determined before and after administration of 1 mg dexamethasone. In 64 subjects multisequential (1-17,1-24,1-39) ACTH, and in 47 subjects intact (1-39) ACTH has been determined. Patients with melancholia exhibited significantly higher postdexamethasone Cortisol and intact ACTH values as compared with minor and simple major depressives. Severity of illness was significantly and positively related to postdexamethasone intact ACTH - but not to multisequential ACTH. Cortisol nonsuppressors showed higher postdexamethasone (only intact) ACTH values than Cortisol suppressors. Both postdexamethasone ACTH values were significantly and positively related with the postdexamethasone Cortisol values. We have established that Cortisol nonsuppression during melancholia is determined by an augmented escape of ACTH from suppression by dexamethasone. Intact ACTH showed the most significant clinical relevance for depression and Cortisol nonsuppression. In the clinical practice we advize the use of postdexamethasone intact ACTH in stead of plasma Cortisol or multisequential ACTH.

Performance of the Dexamethasone Suppression Test in Depressive Illness According to ICD and DSM-III Classification Systems

1988 ◽  
Vol 152 (4) ◽  
pp. 554-558 ◽  
Author(s):  
Sarah Watkins ◽  
Brian Harris ◽  
Nigel Cook ◽  
Roger Thomas ◽  
Diana Riad-Fahmy
Keyword(s):  
Major Depressive Episode ◽  
Depressive Illness ◽  
Dexamethasone Suppression Test ◽  
Classification Systems ◽  
Manic Depressive Illness ◽  
Major Depressive ◽  
Diagnostic Categories ◽  
Manic Depressive ◽  
Suppression Test ◽  
Dexamethasone Suppression

The performance of the dexamethasone suppression test was assessed in 90 consecutive admissions with a diagnosis of depression, categorised according to two classification systems (DSM-III and ICD-9). Non-suppression was found in most of the diagnostic categories, but there was a highly significant association with the DSM-III classification ‘major depressive episode with melancholia’ (52%) in comparison with the ICD group ‘manic-depressive illness-depressed’ (29%).

Sign in / Sign up

Export Citation Format

Share Document