Glucose Metabolism, Insulin Resistance, and Renal Pathology in Non-Diabetic Chronic Kidney Disease

2008 ◽  
Vol 108 (2) ◽  
pp. c163-c168 ◽  
Author(s):  
Ryota Ikee ◽  
Yoshifumi Hamasaki ◽  
Machiko Oka ◽  
Kyoko Maesato ◽  
Tsutomu Mano ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Chronic Kidney Disease ◽  
Glucose Metabolism ◽  
Kidney Disease ◽  
Renal Pathology

An observational study of the effects of telmisartan on insulin resistance in hypertensive patients with chronic kidney disease undergoing hemodialysis

2019 ◽  
Author(s):  
budi suprapti ◽  
Bayu Dharma ◽  
Mahadri Drik ◽  
Zamrottul Izzah ◽  
Wenny Nilamsari ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Antihypertensive Drugs ◽  
Model Assessment ◽  
Hypertensive Patients ◽  
Fasting Plasma ◽  
Homeostatic Model Assessment ◽  
Observational Cohort ◽  
The Mean

Abstract Background In the clinical setting, the activity of telmisartan in decreasing insulin resistance has been proven superior to other antihypertensive drugs in hypertensive patients. However, there has been no published study in determining the effect of telmisartan on insulin resistance in hypertensive chronic kidney disease patients undergoing hemodialysis.Objective To analyze the effect of telmisartan on insulin resistance in hypertensive patients undergoing hemodialysis.Method It was a prospective observational cohort study in 16 chronic kidney disease patients undergoing regular hemodialysis and using telmisartan who met the inclusion criteria.Results Sixteen patients received telmisartan, 12 were male patients and four were female. The mean age was 45 ± 8 years and the mean body mass index was 22.85 ± 1.99. Hypertensive chronic kidney disease was the highest etiology (56%) for hemodialysis. Mean percentage of fasting plasma insulin and homeostatic model assessment of insulin resistance concentratons decreased significantly by 22.6% (P<0.05) and 22.9% (P<0.05) respectively after 3-month administration. On the other hand, the mean percentage of fasting plasma glucose concentrations declined by 2.9% (P=0.187, Zcount<1.96) after 3-month of treatment.Conclusion Administration of telmisartan for three months decreases insulin resistance significantly in hypertensive patients undergoing hemodialysis.

scholarly journals SP289MTORC1 SIGNALING IN INSULIN RESISTANCE RATS WITH CHRONIC KIDNEY DISEASE

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii203-iii203
Author(s):  
Li Zhang ◽  
Jiao Li ◽  
Zhuo Xu ◽  
Yang Zhao ◽  
Xiangmei Chen
Keyword(s):  
Insulin Resistance ◽  
Chronic Kidney Disease ◽  
Kidney Disease

Insulin resistance, microalbuminuria, and chronic kidney disease

2008 ◽  
Vol 10 (4) ◽  
pp. 249-251 ◽  
Author(s):  
Pantelis A. Sarafidis ◽  
Luis M. Ruilope
Keyword(s):  
Insulin Resistance ◽  
Chronic Kidney Disease ◽  
Kidney Disease
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