Changes in Sciatic Nerve Protein Composition during Postnatal Development of Mice

1979 ◽  
Vol 2 (2) ◽  
pp. 51-64 ◽  
Author(s):  
Douglas E. Groswald ◽  
Marvin W. Luttges
Keyword(s):  
Sciatic Nerve ◽  
Postnatal Development ◽  
Protein Composition

scholarly journals Proteins from sciatic-nerve myelin in quaking and jimpy mice

1978 ◽  
Vol 173 (3) ◽  
pp. 989-991 ◽  
Author(s):  
J M Matthieu
Keyword(s):  
Sciatic Nerve ◽  
Protein Composition ◽  
Myelin Proteins ◽  
Myelin Protein ◽  
Sciatic Nerves ◽  
Jimpy Mice ◽  
Quaking Mice

Myelin from two neurological mutants in mice was isolated from sciatic nerves and its protein composition analysed. In Quaking mice, two intrinsic myelin proteins P1 and P2 were drastically decreased, whereas the major myelin protein P0 was unaffected. A normal protein composition was found in sciatic myelin from Jimpy mice.

Arsenic-induced toxicity: effect on protein composition in sciatic nerve

2006 ◽  
Vol 25 (11) ◽  
pp. 667-674 ◽  
Author(s):  
A Vahidnia ◽  
F Romijn ◽  
M Tiller ◽  
G B van der Voet ◽  
F A de Wolff
Keyword(s):  
Sciatic Nerve ◽  
Peripheral Nerves ◽  
Protein Composition ◽  
Arsenic Compounds ◽  
Neurotoxic Effects ◽  
Electrophysiological Studies ◽  
Male Wistar Rats ◽  
Sciatic Nerves ◽  
L Proteins

Exposure to arsenic compounds may lead to skin and lung cancer and various disorders such as vascular disease and peripheral neuropathy in humans. Peripheral arsenic neurotoxicity has been demonstrated clinically and in electrophysiological studies. Patients intoxicated with arsenic show neurological symptoms in their feet and hands. These patients show significantly lower nerve conduction velocities (NCVs) in their peripheral nerves in comparison with controls. The mechanism of arsenic peripheral nervous system (PNS) toxicity, however, has never been described before. This is the first study to investigate the toxicity of arsenic on the PNS. Male Wistar rats were exposed to arsenite given as a single dose i.v. After sacrifice, sciatic nerves were excised and the protein composition was analysed. Protein analysis of sciatic nerves showed disappearance of neurofilament and fibroblast proteins in rats treated with arsenite doses of 15 and 20 mg/kg in comparison with the control groups. Some fibroblast protein bands had disappeared in the 20-mg/kg dose group. The analysed neurofilament-M and-L proteins decreased dose dependency over time. arsenic affects the composition of proteins in the rat sciatic nerve, especially the neurofilaments. The reduction of signals in Western blot analysis reveals changes in cytoskeletal composition, which may well lead to neurotoxic effects in vivo.

Paranodal dysmyelination and increase in tetrodotoxin binding sites in the sciatic nerve of the motor end-plate disease () mouse during postnatal development

1984 ◽  
Vol 101 (2) ◽  
pp. 401-409 ◽  
Author(s):  
François Rieger ◽  
Martine Pinçon-Raymond ◽  
Alain Lombert ◽  
Gilles Ponzio ◽  
Michel Ladunski ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Postnatal Development ◽  
Binding Sites ◽  
End Plate ◽  
Motor End Plate

scholarly journals SPECIFIC FEATURES OF THE STRUCTURAL ORGANIZATION OF THE PARANEURAL CONNECTIVE TISSUE OF THE RAT SITIATIC NERVE IN DIFFERENT PERIODS OF POSTNATAL DEVELOPMENT

2020 ◽  
Vol 76 (4) ◽  
pp. 152-155
Author(s):  
K.M. Borodina ◽  
◽  
M.A. Zatolokina ◽  
V.V. Kharchenko ◽  
A.A. Ten'kov ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Connective Tissue ◽  
Postnatal Development ◽  
Structural Organization ◽  
Structural Features ◽  
Conductive Component ◽  
The Moment

The lack of a sufficient amount of data on the structural features of the paraneural structures of the sciatic nerve at different periods of ontogenesis contributed to the conduct of this study, as a result of which it was revealed that with an increase in the number of days from the moment of birth, a complication of the structure of the «paraneuria» was observed in an inextricable connection with the complication of the structure of the endo, peri-, epineuria and the conductive component of the sciatic nerve. «Morphological improvement» was manifested both in the appearance of new structures in the «paraneuria» and in a change in the ratio of the cellular and fibrous components of the connective tissue, which is its morphological substrate.

scholarly journals Protein composition of the muscle mitochondrial reticulum during postnatal development

2019 ◽  
Vol 597 (10) ◽  
pp. 2707-2727 ◽  
Author(s):  
Yuho Kim ◽  
Daniel S. Yang ◽  
Prasanna Katti ◽  
Brian Glancy
Keyword(s):  
Postnatal Development ◽  
Protein Composition ◽  
Mitochondrial Reticulum
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