Inhibition of VEGF Expression by Targeting HIF-1α with Small Interference RNA in Human RPE Cells

2007 ◽  
Vol 221 (6) ◽  
pp. 411-417 ◽  
Author(s):  
Peng Zhang ◽  
Yusheng Wang ◽  
Yannian Hui ◽  
Dan Hu ◽  
Haiyan Wang ◽  
...  
Keyword(s):  
Vegf Expression ◽  
Small Interference Rna ◽  
Rpe Cells ◽  
Interference Rna ◽  
Human Rpe Cells

scholarly journals Tangeretin Inhibition of High-Glucose-Induced IL-1β, IL-6, TGF-β1, and VEGF Expression in Human RPE Cells

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Dong Qin ◽  
Yan-rong Jiang
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
High Glucose ◽  
Transforming Growth Factor ◽  
Retinal Pigment ◽  
Antioxidant Properties ◽  
Vegf Expression ◽  
Rpe Cells ◽  
Tgf Β1 ◽  
Human Rpe Cells

Tangeretin, a natural compound extracted from citrus plants, has been reported to have antiproliferative, antidiabetic, anti-invasive, and antioxidant properties. However, the role of tangeretin in diabetic retinopathy (DR) is unknown. In the present study, we investigated whether tangeretin had any effect on the expression of interleukin 1 beta (IL-1β), interleukin 6 (IL-6), transforming growth factor beta 1 (TGF-β1), and vascular endothelial growth factor (VEGF) in human retinal pigment epithelial (RPE) cells under high-glucose (HG) conditions. Our results illustrated that HG levels induced IL-1β, IL-6, TGF-β1, and VEGF expression and that tangeretin significantly reduced HG-induced IL-1β, IL-6, TGF-β1, and VEGF expression in human RPE cells. Moreover, tangeretin efficiently inhibited the activation of the protein kinase B (Akt) signalling pathway in HG-stimulated RPE cells. Therefore, tangeretin may serve a role in the treatment of DR.

Complement-mediated release of fibroblast growth factor 2 from human RPE cells

2021 ◽  
Vol 204 ◽  
pp. 108471
Author(s):  
Ping Yang ◽  
Samantha E. Neal ◽  
Kristen L. Buehne ◽  
Grace M. Tewkesbury ◽  
Mikael Klingeborn ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Rpe Cells ◽  
Human Rpe Cells

scholarly journals Identification of Human Kinases Involved in Hepatitis C Virus Replication by Small Interference RNA Library Screening

2007 ◽  
Vol 283 (1) ◽  
pp. 29-36 ◽  
Author(s):  
Lubica Supekova ◽  
Frantisek Supek ◽  
Jongkook Lee ◽  
Shawn Chen ◽  
Nathanael Gray ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Replication ◽  
Library Screening ◽  
Small Interference Rna ◽  
Interference Rna

scholarly journals Magnetic gold nanoparticle-mediated small interference RNA silencing Bag-1 gene for colon cancer therapy

2015 ◽  
Vol 35 (2) ◽  
pp. 978-984 ◽  
Author(s):  
WENBAI HUANG ◽  
ZHAN'AO LIU ◽  
GUANZHOU ZHOU ◽  
AILING TIAN ◽  
NIANFENG SUN
Keyword(s):  
Colon Cancer ◽  
Cancer Therapy ◽  
Gold Nanoparticle ◽  
Rna Silencing ◽  
Small Interference Rna ◽  
Interference Rna

Reversal of chemoresistance with small interference RNA (siRNA) in etoposide resistant acute myeloid leukemia cells (HL-60)

2015 ◽  
Vol 75 ◽  
pp. 100-104 ◽  
Author(s):  
Saeed Kachalaki ◽  
Behzad Baradaran ◽  
Jafar Majidi ◽  
Mehdi Yousefi ◽  
Dariush Shanehbandi ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Leukemia Cells ◽  
Small Interference Rna ◽  
Acute Myeloid Leukemia Cells ◽  
Interference Rna ◽  
Acute Myeloid

Diphenyleneiodonium induces ROS-independent p53 expression and apoptosis in human RPE cells

FEBS Letters ◽  
2006 ◽  
Vol 581 (2) ◽  
pp. 180-186 ◽  
Author(s):  
Sang Eun Park ◽  
Ju Dong Song ◽  
Kang Mi Kim ◽  
Yeong Min Park ◽  
Nam Deuk Kim ◽  
...  
Keyword(s):  
P53 Expression ◽  
Rpe Cells ◽  
Human Rpe Cells

Tat-BMPs-PAMAM Conjugates Enhance Therapeutic Effect of Small Interference RNA on U251 Glioma Cells In Vitro and In Vivo

2010 ◽  
Vol 21 (4) ◽  
pp. 417-426 ◽  
Author(s):  
Lei Han ◽  
Anling Zhang ◽  
Hanjie Wang ◽  
Peiyu Pu ◽  
Xinguo Jiang ◽  
...  
Keyword(s):  
Therapeutic Effect ◽  
Glioma Cells ◽  
Small Interference Rna ◽  
Interference Rna

Inhibition of hepatitis B virus replication by small interference RNA induces expression of MICA in HepG2.2.15 cells

2008 ◽  
Vol 198 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Kai-Fu Tang ◽  
Min Chen ◽  
Jing Xie ◽  
Guan-Bin Song ◽  
Yi-Song Shi ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Replication ◽  
Small Interference Rna ◽  
B Virus ◽  
Interference Rna
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