MAO A and B Immunoreactivity in the Hippocampus, Temporal Cortex and Cerebellum of Normal Controls and of Patients with Senile Dementia of the Alzheimer Type (Part 1 of 2)

1992 ◽  
Vol 3 (5-6) ◽  
pp. 270-276 ◽  
Author(s):  
T. Zetzsche ◽  
V. Chan-Palay
Keyword(s):  
Senile Dementia ◽  
Temporal Cortex ◽  
Alzheimer Type ◽  
Mao A ◽  
Normal Controls ◽  
Senile Dementia Of The

Analysis of the Structure of Paired Helical Filaments

1985 ◽  
Vol 43 ◽  
pp. 734-737
Author(s):  
R.A. Crowther ◽  
C.M. Wischik ◽  
M. Stewart
Keyword(s):  
Senile Dementia ◽  
Temporal Cortex ◽  
Paired Helical Filaments ◽  
Paired Helical Filament ◽  
Post Mortem ◽  
Alzheimer Type ◽  
Large Numbers ◽  
Distinctive Morphology ◽  
The Brain ◽  
Senile Dementia Of The

The neurofibrillary tangles that occur in the brain in senile dementias of the Alzheimer type contain a class of filament with a distinctive morphology, the paired helical filament (PHF). Rather little definitive information is available about the structure or biochemical nature of the PHF. We have recently made a detailed ultrastructural analysis of PHFs. We will summarise here the results of that study, as the findings have an important bearing on the interpretation of the image reconstructions presented below.PHF enriched fractions were prepared from brains obtained post-mortem from cases with a clinical diagnosis of senile dementia of the Alzheimer type, confirmed histologically by the presence of large numbers of plaques and tangles in frontal and temporal cortex. The preparative protocol involved a series of differential centrifugations.

[3H]R05-4864 and [3H]flunitrazepam binding in kainate-lesioned rat striatum and in temporal cortex of brains from patients with senile dementia of the Alzheimer type

1983 ◽  
Vol 278 (1-2) ◽  
pp. 373-375 ◽  
Author(s):  
Frank Owen ◽  
Mark Poulter ◽  
John L. Waddington ◽  
Robert D. Mashal ◽  
Timothy J. Crow
Keyword(s):  
Senile Dementia ◽  
Temporal Cortex ◽  
Rat Striatum ◽  
Alzheimer Type ◽  
Senile Dementia Of The

Computed Tomographic Density Numbers

1986 ◽  
Vol 149 (6) ◽  
pp. 716-719 ◽  
Author(s):  
J. Colgan ◽  
M. Naguib ◽  
R. Levy
Keyword(s):  
Senile Dementia ◽  
Brain Regions ◽  
Cranial Computed Tomography ◽  
Linear Measure ◽  
Alzheimer Type ◽  
Maximum Width ◽  
Computed Tomographic ◽  
Lateral Ventricles ◽  
Normal Controls ◽  
Senile Dementia Of The

Cranial computed tomography (CT) scans of 48 patients with senile dementia of the Alzheimer type (SDAT) and 40 normal elderly volunteers were compared. The demented group were found to have significantly larger lateral ventricles assessed planimetrically and by using a linear measure of the ratio of the maximum width of the frontal horns of the lateral ventricles to the maximum intracranial diameter. Attenuation density was computed for 1 5 brain regions. The demented group did not differ significantly from the normal controls with respect to attenuation density In any of the regions studied.

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