Autoantibodies against Glutamate Receptor ε2-Subunit Detected in a Subgroup of Patients with Reversible Autoimmune Limbic Encephalitis

2007 ◽  
Vol 58 (3) ◽  
pp. 152-158 ◽  
Author(s):  
A. Kimura ◽  
T. Sakurai ◽  
Y. Suzuki ◽  
Y. Hayashi ◽  
I. Hozumi ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Limbic Encephalitis ◽  
Autoimmune Limbic Encephalitis

scholarly journals Toxic Epidermal Necrolysis in a Patient with Autoimmune Limbic Encephalitis with Anti-Glutamate Receptor Antibodies

2018 ◽  
Vol 10 (2) ◽  
pp. 207-212 ◽  
Author(s):  
Keiko Hatano ◽  
Hideyuki Matsumoto ◽  
Akihiko Mitsutake ◽  
Junko Yoshimura ◽  
Aya Nomura ◽  
...  
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Glutamate Receptor ◽  
Rare Diseases ◽  
Limbic Encephalitis ◽  
Recovery Phase ◽  
Autoimmune Limbic Encephalitis ◽  
Receptor Antibodies

We report on a 44-year-old woman who was diagnosed with toxic epidermal necrolysis (TEN) during the recovery phase from autoimmune limbic encephalitis with anti-glutamate receptor antibodies. Both, autoimmune limbic encephalitis and TEN are very rare diseases. The co-existence of the two diseases has not yet been reported. We speculate that the total of 18 drugs needed for the treatment of encephalitis might have increased the risk of TEN. Similar reports would be required to elucidate the pathophysiology of the co-existence.

ASL MRI and 18F-FDG-PET in autoimmune limbic encephalitis: clues from two paradigmatic cases

2021 ◽  
Author(s):  
Alessandro Dinoto ◽  
Marta Cheli ◽  
Miloš Ajčević ◽  
Franca Dore ◽  
Carmelo Crisafulli ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Limbic Encephalitis ◽  
Autoimmune Limbic Encephalitis ◽  
18F Fdg

Botryoid nuclei of neutrophils and monocytes in autoimmune limbic encephalitis

2012 ◽  
Vol 95 (4) ◽  
pp. 329-330 ◽  
Author(s):  
Akihito Fujimi ◽  
Yuki Ikeda ◽  
Kaoru Ono ◽  
Yuji Kanisawa
Keyword(s):  
Limbic Encephalitis ◽  
Autoimmune Limbic Encephalitis

scholarly journals Determinants of cognition in autoimmune limbic encephalitis—A retrospective cohort study

Hippocampus ◽  
2021 ◽  
Author(s):  
Christoph Mueller ◽  
Lisa M. Langenbruch ◽  
Johanna M. H. Rau ◽  
Tobias Brix ◽  
Christine Strippel ◽  
...  
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Limbic Encephalitis ◽  
Autoimmune Limbic Encephalitis

Autoimmune Limbic Encephalitis

2019 ◽  
pp. 567-597
Author(s):  
Shahar Shelly ◽  
Ram Narayan ◽  
Divyanshu Dubey
Keyword(s):  
Limbic Encephalitis ◽  
Autoimmune Limbic Encephalitis

Glioblastoma as an autoimmune limbic encephalitis mimic: A case and review of the literature

2020 ◽  
Vol 342 ◽  
pp. 577214
Author(s):  
Zachary A. Macchi ◽  
B.K. Kleinschmidt-DeMasters ◽  
Karen D. Orjuela ◽  
Daniel M. Pastula ◽  
Amanda L. Piquet ◽  
...  
Keyword(s):  
Limbic Encephalitis ◽  
Review Of The Literature ◽  
Autoimmune Limbic Encephalitis

scholarly journals Fulminant thymomatous AMPAR-antibody limbic encephalitis with hypertonic coma, bruxism, an isoelectric electroencephalogram and temporal cortical atrophy, with recovery

2019 ◽  
Vol 12 (2) ◽  
pp. e227893
Author(s):  
Nicolás Urriola ◽  
Kavie Soosapilla ◽  
James Drummond ◽  
Mark Thieben
Keyword(s):  
Botulinum Toxin ◽  
Glutamate Receptor ◽  
Limbic Encephalitis ◽  
Botulinum Toxin Injection ◽  
Autoimmune Encephalitis ◽  
Cortical Atrophy ◽  
Impaired Consciousness ◽  
Clinical Recovery ◽  
Clinical Presentations ◽  
Electroencephalogram Eeg

Autoimmune encephalitides are a potentially devastating group of treatable disorders with a wide variety of clinical presentations. The most studied autoimmune encephalitis is caused by antibodies to the N-methyl-D-aspartate glutamate receptor. A rarer cause is due to antibodies against the evolutionarily related α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR). The full assortment of electroencephalogram (EEG) and clinical descriptions of the latter are yet to be fully described. A 44-year-old woman with impaired consciousness and subsequent coma characterised by an isoelectric EEG was diagnosed with AMPAR-antibody limbic encephalitis. MRI revealed temporal T2 hyperintensities that improved with immunosuppression, although leaving marked cortical atrophy. Gradual clinical improvement saw the development of aggressive bruxism requiring botulinum toxin injection with eventual meaningful clinical recovery. This case expands the clinical spectrum of AMPAR limbic encephalitis to include aggressive bruxism, and highlights that despite poor clinical and EEG findings at the outset, recovery is still possible.

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