The Pathology of Mueller Cells under Different Disease Conditions

2006 ◽  
Vol 4 (1-2) ◽  
pp. 61-75 ◽  
Author(s):  
Shimpei Nishikawa
Keyword(s):  
Mueller Cells

scholarly journals Increased Expression of Low-affinity NGF Receptor in Rat Retinal Mueller Cells after Ischemia and Reperfusion.

1998 ◽  
Vol 23 (4) ◽  
pp. 201-207 ◽  
Author(s):  
Hiroshi Tomita ◽  
Seiichi Ishiguro ◽  
Toshiaki Abe ◽  
Makoto Tamai
Keyword(s):  
Ischemia And Reperfusion ◽  
Mueller Cells ◽  
Ngf Receptor

scholarly journals An immunohistochemical study of the Mueller cells of the chicken retina.

1980 ◽  
Vol 43 (2) ◽  
pp. 175-183 ◽  
Author(s):  
Akira IKEDA ◽  
Itaru YOSHII ◽  
Noboru MISHIMA
Keyword(s):  
Immunohistochemical Study ◽  
Mueller Cells ◽  
Chicken Retina

scholarly journals Evaluation of AAV-DJ vector for retinal gene therapy

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e6317 ◽  
Author(s):  
Yusaku Katada ◽  
Kenta Kobayashi ◽  
Kazuo Tsubota ◽  
Toshihide Kurihara
Keyword(s):  
Gene Therapy ◽  
Gene Transfer ◽  
Cell Types ◽  
Egfp Expression ◽  
Adeno Associated Virus ◽  
Photoreceptor Layer ◽  
Mueller Cells ◽  
Efficient Gene ◽  
Clinical Gene Therapy ◽  
Preclinical And Clinical Studies

Purpose The most common virus vector used in gene therapy research for ophthalmologic diseases is the adeno-associated virus (AAV) vector, which has been used successfully in a number of preclinical and clinical studies. It is important to evaluate novel AAV vectors in animal models for application of clinical gene therapy. The AAV-DJ (type 2/type 8/type 9 chimera) was engineered from shuffling eight different wild-type native viruses. In this study, we investigated the efficiency of gene transfer by AAV-DJ injections into the retina. Methods One microliter of AAV-2-CAGGS-EGFP or AAV-DJ-CAGGS-EGFP vector at a titer of 1.4 × 10e12 vg/ml was injected intravitreally or subretinally in each eye of C57BL/6 mice. We evaluated the transduction characteristics of AAV-2 and -DJ vectors using fluorescence microscopy and electroretinography. Results The results confirmed that AAV-DJ could deeply transfer gene to photoreceptor layer with intravitreal injection and has an efficient gene transfer to various cell types especially the Mueller cells in the retina. Retinal function was not affected by AAV-DJ infection or ectopic EGFP expression. Conclusions The AAV-DJ vector efficiently induces the reporter gene in both the inner and outer murine retina without functional toxicity. These data indicated that the AAV-DJ vector is a useful tool for the gene therapy research targeting retinal disorders.

Induction of fibroblast growth factor-2 by electrical stimulation in cultured retinal Mueller cells

Neuroreport ◽  
2008 ◽  
Vol 19 (16) ◽  
pp. 1617-1621 ◽  
Author(s):  
Tatsuhiko Sato ◽  
Tong-Sheng Lee ◽  
Fumihiko Takamatsu ◽  
Takashi Fujikado
Keyword(s):  
Electrical Stimulation ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Mueller Cells
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