GBR12909 Possesses Anticonvulsant Activity in Zebrafish and Rodent Models of Generalized Epilepsy but Cardiac Ion Channel Effects Limit Its Clinical Utility

Pharmacology ◽  
2007 ◽  
Vol 79 (4) ◽  
pp. 250-258 ◽  
Author(s):  
Paul Goldsmith ◽  
Zoe Golder ◽  
Julia Hunt ◽  
Stephane Berghmans ◽  
Derek Jones ◽  
...  
Keyword(s):  
Ion Channel ◽  
Anticonvulsant Activity ◽  
Clinical Utility ◽  
Rodent Models ◽  
Channel Effects ◽  
Generalized Epilepsy

Screening of Pistacia integerrima extracts for their anticonvulsant activity in acute zebrafish and rodent models of epilepsy

2015 ◽  
Vol 5 (2) ◽  
pp. 56 ◽  
Author(s):  
Sadhana Sathaye ◽  
PankajD Jain ◽  
RufiM Tambe ◽  
JayantS Sancheti ◽  
MruniyaS Nahire ◽  
...  
Keyword(s):  
Anticonvulsant Activity ◽  
Rodent Models ◽  
Models Of Epilepsy

scholarly journals Precision physiology and rescue of brain ion channel disorders

2017 ◽  
Vol 149 (5) ◽  
pp. 533-546 ◽  
Author(s):  
Jeffrey Noebels
Keyword(s):  
Ion Channel ◽  
Clinical Utility ◽  
Clinical Decision Making ◽  
Central Nervous System Disease ◽  
Clinical Decision ◽  
Channel Structure ◽  
Clinical Severity ◽  
Developmental Relationships ◽  
System Disease ◽  
Phenotypic Spectrum

Ion channel genes, originally implicated in inherited excitability disorders of muscle and heart, have captured a major role in the molecular diagnosis of central nervous system disease. Their arrival is heralded by neurologists confounded by a broad phenotypic spectrum of early-onset epilepsy, autism, and cognitive impairment with few effective treatments. As detection of rare structural variants in channel subunit proteins becomes routine, it is apparent that primary sequence alone cannot reliably predict clinical severity or pinpoint a therapeutic solution. Future gains in the clinical utility of variants as biomarkers integral to clinical decision making and drug discovery depend on our ability to unravel complex developmental relationships bridging single ion channel structure and human physiology.

Evaluation of drug-mediated arrhythmic changes in spontaneous beating cardiomyocytes by AFM

The Analyst ◽  
2016 ◽  
Vol 141 (22) ◽  
pp. 6303-6313 ◽  
Author(s):  
A. T. Chen ◽  
S. Zou
Keyword(s):  
Drug Development ◽  
Ion Channel ◽  
Channel Effects

An AFM-based approach to investigate compound-induced ion channel effects in cardiomyocytes for pre-screening drug development.

From antiarrhythmics to anticonvulsants: ADD424042, a Disopyramide derivative, is a non-cardiotoxic ion channel blocker with broad-spectrum anticonvulsant activity

2015 ◽  
Vol 67 ◽  
pp. 13-14
Author(s):  
Marcin Ufnal ◽  
Marek Król ◽  
Piotr Podsadni ◽  
Bartłomiej Szulczyk ◽  
Jadwiga Turło ◽  
...  
Keyword(s):  
Ion Channel ◽  
Broad Spectrum ◽  
Anticonvulsant Activity ◽  
Channel Blocker

In Vitro Electrocardiographic and Cardiac Ion Channel Effects of (−)-Epigallocatechin-3-Gallate, the Main Catechin of Green Tea

2010 ◽  
Vol 334 (2) ◽  
pp. 619-626 ◽  
Author(s):  
Jiesheng Kang ◽  
Hsien Cheng ◽  
Junzhi Ji ◽  
Josephine Incardona ◽  
David Rampe
Keyword(s):  
Ion Channel ◽  
Green Tea ◽  
Channel Effects

Cardiac Myocyte Damage, Electrocardiographic Dysfunction, and Ion Channel Remodeling in Rodent Models of Seizure Disorders

2015 ◽  
pp. 235-240
Author(s):  
Steven Bealer ◽  
Cameron Metcalf ◽  
Steven Poelzing ◽  
Jason Little ◽  
Amy Brewster ◽  
...  
Keyword(s):  
Ion Channel ◽  
Cardiac Myocyte ◽  
Rodent Models ◽  
Seizure Disorders ◽  
Myocyte Damage

Comparison of HERG ion channel effects in HEK cells and action potential duration in human iPSC cardiomyocytes

2016 ◽  
Vol 81 ◽  
pp. 347
Author(s):  
Priyanka Saxena ◽  
Maria P. Hortigon-Vinagre ◽  
Ana Costa ◽  
Eugen Timin ◽  
Stanislav Beyl ◽  
...  
Keyword(s):  
Action Potential ◽  
Ion Channel ◽  
Action Potential Duration ◽  
Hek Cells ◽  
Channel Effects ◽  
Human Ipsc
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