Intraductal Adenoma and Epithelial Hyperplasia of the Pancreatic Ducts

2007 ◽  
pp. 228-236
Author(s):  
Keiko Abe ◽  
Koichi Suda ◽  
Hiroshi Sonoue
Keyword(s):  
Pancreatic Ducts ◽  
Epithelial Hyperplasia

scholarly journals Cryptosporidiosis in Two Juvenile Rhesus Monkeys

1972 ◽  
Vol 9 (6) ◽  
pp. 426-440 ◽  
Author(s):  
R. M. Kovatch ◽  
J. D. White
Keyword(s):  
Epithelial Cells ◽  
Gall Bladder ◽  
Rhesus Monkeys ◽  
The Other ◽  
Mucosal Inflammation ◽  
Pancreatic Ducts ◽  
Epithelial Hyperplasia ◽  
The Common

A coccidium of the genus Cryptosporidium, previously unreported in simians, was observed in two juvenile Rhesus monkeys. The organisms were restricted in one to the epithelium of the common bile, intrahepatic and pancreatic ducts and gall bladder and in the other to the epithelium of the small and large intestines. Epithelial hyperplasia and mucosal inflammation were common histologic features. Small bulbous enlargements that might be misinterpreted as cryptosporidia projected from the epithelial cells of some gall bladders of noninfected monkeys.

Electron Microscopic Study of the Epithelium of the Seminal Vesicle of Aging Rats

1974 ◽  
Vol 32 ◽  
pp. 138-139
Author(s):  
V. F. Allison ◽  
G. C. Fink ◽  
G. W. Cearley
Keyword(s):  
Cell Growth ◽  
Epithelial Cell ◽  
Epithelial Cells ◽  
Seminal Vesicle ◽  
Seminal Vesicles ◽  
Epithelial Layer ◽  
Epithelial Hyperplasia ◽  
Electron Microscopic ◽  
Aging Rats ◽  
Pseudostratified Epithelium

It is well known that epithelial hyperplasia (benign hypertrophy) is common in the aging prostate of dogs and man. In contrast, little evidence is available for abnormal epithelial cell growth in seminal vesicles of aging animals. Recently, enlarged seminal vesicles were reported in senescent mice, however, that enlargement resulted from increased storage of secretion in the lumen and occurred concomitant to epithelial hypoplasia in that species.The present study is concerned with electron microscopic observations of changes occurring in the pseudostratified epithelium of the seminal vescles of aging rats. Special attention is given to certain non-epithelial cells which have entered the epithelial layer.

CAPILLARY PATTERN OF THE THYROID GLAND IN THE RAT IN FUNCTIONAL BLOCK

1962 ◽  
Vol 40 (3) ◽  
pp. 441-450 ◽  
Author(s):  
K. E. Arosenius ◽  
G. Nylander
Keyword(s):  
Thyroid Gland ◽  
Control Group ◽  
List Type ◽  
Epithelial Hyperplasia ◽  
Intact Control ◽  
Functional Block ◽  
Propyl Thiouracil

ABSTRACT The capillary pattern of the thyroid gland was studied in the rat: one group had undergone hemithyroidectomy, one was treated with propyl thiouracil, and one subjected to both these experimental measures. Histological and microangiographic observations were compared with those in an intact control group. Epithelial hyperplasia and other morphological signs of activity were seen to a moderate extent in the hemithyroidectomized group, were marked in the rats treated with thiouracil, and most marked in the group subjected to both thiouracil medication and hemithyroidectomy. The appearances of the interfollicular capillaries showed no perceptible changes in the group subjected solely to hemithyroidectomy. Changes of the interfollicular capillaries were marked in all the animals treated with propyl thiouracil. In the group only treated with propyl thiouracil, the capillaries were dilated to sinusoid-like blood pools in limited segments between which the capillaries were of normal width. In the group subjected to both hemithyroidectomy and propyl thiouracil treatment the interfollicular capillaries were dilated throughout their course. The significance of these morphological and microangiographic observations is discussed.

scholarly journals Pre-Operative Imaging and Pathological Diagnosis of Localized High-Grade Pancreatic Intra-Epithelial Neoplasia without Invasive Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 945
Author(s):  
Ryota Sagami ◽  
Kentaro Yamao ◽  
Jun Nakahodo ◽  
Ryuki Minami ◽  
Masakatsu Tsurusaki ◽  
...  
Keyword(s):  
Pancreatic Duct ◽  
Invasive Carcinoma ◽  
Current Knowledge ◽  
Precancerous Lesions ◽  
Ductal Adenocarcinoma ◽  
Pancreatic Ducts ◽  
High Grade ◽  
Cytologic Examination ◽  
Imaging Characteristics ◽  
Retention Cysts

Pancreatic ductal adenocarcinoma (PDAC) arises from precursor lesions, such as pancreatic intra-epithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN). The prognosis of high-grade precancerous lesions, including high-grade PanIN and high-grade IPMN, without invasive carcinoma is good, despite the overall poor prognosis of PDAC. High-grade PanIN, as a lesion preceding invasive PDAC, is therefore a primary target for intervention. However, detection of localized high-grade PanIN is difficult when using standard radiological approaches. Therefore, most studies of high-grade PanIN have been conducted using specimens that harbor invasive PDAC. Recently, imaging characteristics of high-grade PanIN have been revealed. Obstruction of the pancreatic duct due to high-grade PanIN may induce a loss of acinar cells replaced by fibrosis and lobular parenchymal atrophy. These changes and additional inflammation around the branch pancreatic ducts (BPDs) result in main pancreatic duct (MPD) stenosis, dilation, retention cysts (BPD dilation), focal pancreatic parenchymal atrophy, and/or hypoechoic changes around the MPD. These indirect imaging findings have become important clues for localized, high-grade PanIN detection. To obtain pre-operative histopathological confirmation of suspected cases, serial pancreatic-juice aspiration cytologic examination is effective. In this review, we outline current knowledge on imaging characteristics of high-grade PanIN.

scholarly journals THE LIVER LIPIDS OF DOGS SUBJECTED TO LIGATION OF THE EXTERNAL PANCREATIC DUCTS

1939 ◽  
Vol 128 (2) ◽  
pp. 387-398
Author(s):  
M.L. Montgomery ◽  
C. Entenman ◽  
I.L. Chaikoff
Keyword(s):  
Pancreatic Ducts ◽  
Liver Lipids

scholarly journals Role of Intraductal RFA: A Novel Tool in the Palliative Care of Perihilar Cholangiocarcinoma

2021 ◽  
pp. 1-9
Author(s):  
Tobias J. Weismüller
Keyword(s):  
Palliative Care ◽  
Overall Survival ◽  
Prospective Studies ◽  
Liver Tumors ◽  
Perihilar Cholangiocarcinoma ◽  
Metal Stents ◽  
Tumor Control ◽  
Pancreatic Ducts ◽  
First Line ◽  
Stent Patency

<b><i>Background:</i></b> Patients with irresectable perihilar cholangiocarcinoma (PHC) have a limited prognosis with median survival times still less than 1 year. In addition to the current standard first-line systemic chemotherapy (gemcitabine and a platinum derivate), endoscopic treatment aims to ensure adequate drainage of the biliary system by placing biliary plastic or metal stents. Local ablative procedures like intraluminal biliary brachytherapy (ILBT) or photodynamic therapy (PDT) are used to improve local tumor control and to optimize the stent patency. <b><i>Summary:</i></b> Intraductal radiofrequency ablation (RFA) is another promising tool in the therapeutic armamentarium for the endoscopic management and tumor ablation of extrahepatic cholangiocarcinoma (eCCA). By applying thermal energy to the tissue through high-frequency alternating current, RFA induces coagulative necrosis and causes local destruction of the tumor. It is established as a first line percutaneous treatment of solid liver tumors, and since 2011 an endoscopic catheter is available that allows intraductal RFA in the biliary or pancreatic ducts. While the first pilot studies primarily evaluated this new method in patients with distal eCCA, there is now evidence accumulating also for PHC. Two retrospective and two prospective studies demonstrated a significantly improved overall survival and a longer stent patency with intraductal RFA, which overall had a favorable safety profile and was not associated with a significant increase in adverse events. However, prospective studies comparing the efficacy and safety of intraductal RFA, PDT, and/or ILBT are lacking. <b><i>Key Messages:</i></b> Recent studies suggest that intraductal RFA is an effective and well-tolerated additional treatment option with regard to stent patency but also overall survival. Since RFA has fewer systemic side effects and requires less logistical effort when compared to ILBT and PDT, intraductal RFA should be considered as another safe and feasible adjuvant method for the palliative care of patients with advanced PHC. Since comparative studies are lacking, the choice of the local ablative method remains in each case an individual decision.

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