Gamma-Knife-Based Stereotactic Radiosurgery for Uveal Melanoma

2007 ◽  
Vol 85 (2-3) ◽  
pp. 106-112 ◽  
Author(s):  
Achilles J. Fakiris ◽  
Simon S. Lo ◽  
Mark A. Henderson ◽  
Thomas C. Witt ◽  
Robert M. Worth ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Uveal Melanoma

Gamma Knife Stereotactic Radiosurgery for Uveal Melanoma: Clinical Results after 2 Years

1996 ◽  
Vol 66 (1) ◽  
pp. 208-213 ◽  
Author(s):  
G. Marchini ◽  
M. Gerosa ◽  
E. Piovan ◽  
A. Pasoli ◽  
S. Babighian ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Uveal Melanoma ◽  
Clinical Results ◽  
Gamma Knife Stereotactic Radiosurgery

scholarly journals Quantitative analysis of Gamma Knife stereotactic radiosurgery for uveal melanoma

2020 ◽  
Vol 26 (2) ◽  
pp. 111-117
Author(s):  
Raj Kishor Bisht ◽  
Gopishankar Natanasabapathi ◽  
Shashank Sharad Kale
Keyword(s):  
Radiation Dose ◽  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Uveal Melanoma ◽  
Planning System ◽  
Treatment Planning System ◽  
Eye Lens ◽  
Organ Doses ◽  
Stereotactic Frame ◽  
Gamma Knife Stereotactic Radiosurgery

AbstractThe purpose of the study was to analyze single fraction Gamma Knife stereotactic radiosurgery (SRS) for uveal melanoma (UM). In the treatment of UMs, the dose distribution exhibited by an irregular eye surface has more calculation uncertainty. A tissue-equivalent bolus was placed on the left eye surface of a human head-shaped phantom. It was assumed that the treated eye is fixed using retrobulbar anesthesia and suture on extraocular muscles for phantom study. Leksell stereotactic frame was fixed around phantom’s head and the stereotactic computed tomography (CT) was performed. Two sets of scans were acquired (a) without bolus and (b) with a bolus of 1.0 cm thickness. These scans were transferred into a treatment planning system (TPS). The skull contouring was performed using stereotactic CT images. The target, visual pathways, and eye lens were delineated in stereotactic CT space created on TPS. A clinical relevant plan was designed on the CT study set “a” to deliver a radiation dose of 30Gy at tumor margin. The plan superimposed over CT study set “b” and compiled for convincing treatment strategy. The tumor coverage was 95% at 50% prescription isodose line. The conformity index, selectivity and the gradient index were 1.27, 0.80 and 3.28 respectively. The left optic nerve and eye lens received a maximum dose of 11.1 Gy and 11.0 Gy respectively. The treatment plan overlay showed similar planning indices and critical organ doses. The plan comparison showed: an irradiated volume received the radiation dose > 15 Gy varies < 1.0% whereas the volume received < 15 Gy were larger (> 1.0%) in the study set “b”. The distant lateral points from the target volume which describe the phantom’s eyelid showed a radiation dose of 3.2 Gy - 2.5 Gy. The doses to these points were misled and ignored in the CT study set “a”. The eye bolus provides better dosimetric information in the estimation of low dose areas which is commonly misled on TPS in SRS planning for UMs.

Skull base aneurysmal bone cyst presenting with hydrocephalus: progressive residuum obliterated by Gamma Knife stereotactic radiosurgery in a pediatric patient

2020 ◽  
Vol 26 (1) ◽  
pp. 76-81
Author(s):  
George H. Tse ◽  
Feng Y. Jiang ◽  
Matthias W. R. Radatz ◽  
Saurabh Sinha ◽  
Hesham Zaki
Keyword(s):  
Skull Base ◽  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Pediatric Population ◽  
Bone Cyst ◽  
Disease Free Survival ◽  
Long Term Follow Up ◽  
Aneurysmal Bone Cysts ◽  
Gamma Knife Stereotactic Radiosurgery

Aneurysmal bone cysts (ABCs) are an uncommon entity predominantly encountered in the pediatric population. The skull is rarely involved, but these cysts have been reported to arise in the skull base. Traditional treatment has been with surgery alone; however, there is a gathering body of literature that reports alternative treatments that can achieve long-term disease-free survival. However, these therapies are predominantly directed at peripheral skeletal lesions. To the authors’ knowledge, this report is the first to describe long-term follow-up of the efficacy of Gamma Knife stereotactic radiosurgery for treatment of ABC residuum in the skull base that resulted in long-term patient stability and likely ABC obliteration.

Frame-Based and Mask-Based Stereotactic Radiosurgery: The Patient Experience, Compared

2021 ◽  
pp. 1-9
Author(s):  
Matthew Pavlica ◽  
Troy Dawley ◽  
Anuj Goenka ◽  
Michael Schulder
Keyword(s):  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Patient Experience ◽  
Malignant Lesion ◽  
Patient Comfort ◽  
Treatment Technique ◽  
Metastatic Lesions ◽  
Treatment Type ◽  
Lesion Type ◽  
Malignant Diagnosis

<b><i>Introduction:</i></b> Noninvasive frameless modalities have become increasingly utilized for stereotactic radiosurgery (SRS) for benign and malignant pathologies. There is minimal comparison in the literature of frame-based (FB) and mask-based (MB) SRS. With the dual capabilities of the Elekta Gamma Knife® Icon™, we sought to compare patient perceptions of FB and MB SRS with respect to comfort and pain and to examine effects of lesion type on the patient experience of SRS. <b><i>Methods:</i></b> Over a 1-year period, patients who underwent single fraction, fractionated or hypofractionated FB or MB Gamma Knife SRS at our institution were given an 8-question survey about their experience with the procedure immediately after treatment was completed. Descriptive statistics were applied. <b><i>Results:</i></b> A total of 117 patients completed the survey with 65 FB and 52 MB SRS treatments. Mean pain for FB SRS (5.64 ± 2.55) was significantly greater than mean pain for MB SRS (0.92 ± 2.24; <i>t</i><sub>114</sub> = 10.46<i>, p</i> &#x3c; 0.001). Patient comfort during the procedure was also higher for those having MB SRS (<i>p</i> &#x3c; 0.001). Mixed results were obtained when investigating if benign versus malignant diagnosis affected patient experience of SRS. For the purposes of this study, malignant diagnoses were almost entirely metastatic lesions. Diagnosis played no role on pain levels when all patients were analyzed together. The treatment technique had no effect on patient comfort in patients with benign diagnoses, while patients with malignant diagnoses treated with MB SRS were more likely to be comfortable (<i>p</i> &#x3c; 0.001). Among patient’s receiving FB treatments, diagnosis played no role on patient comfort. When only MB treatments were analyzed, patients were more likely to be comfortable if they had a malignant lesion (<i>p</i> &#x3c; 0.01). <b><i>Conclusions:</i></b> Patients treated with MB SRS experience the procedure as more comfortable and less painful compared to those treated using a FB modality. Overall, this difference was not affected by a benign versus a malignant diagnosis and the treatment type is more indicative of the patient experience during SRS. A more homogenous sample between modalities and diagnoses and further follow-up with the patient’s input on their experience would be beneficial.

scholarly journals Brainstem metastases treated with Gamma Knife stereotactic radiosurgery: the Indiana University Health experience

CNS Oncology ◽  
2018 ◽  
Vol 7 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Ajay Patel ◽  
Homan Mohammadi ◽  
Tuo Dong ◽  
Kevin Ren-Yeh Shiue ◽  
Douglas Frye ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Indiana University ◽  
Gamma Knife Stereotactic Radiosurgery
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