Gamma Knife Stereotactic Radiosurgery for Uveal Melanoma: Clinical Results after 2 Years

1996 ◽  
Vol 66 (1) ◽  
pp. 208-213 ◽  
Author(s):  
G. Marchini ◽  
M. Gerosa ◽  
E. Piovan ◽  
A. Pasoli ◽  
S. Babighian ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Uveal Melanoma ◽  
Clinical Results ◽  
Gamma Knife Stereotactic Radiosurgery

scholarly journals Quantitative analysis of Gamma Knife stereotactic radiosurgery for uveal melanoma

2020 ◽  
Vol 26 (2) ◽  
pp. 111-117
Author(s):  
Raj Kishor Bisht ◽  
Gopishankar Natanasabapathi ◽  
Shashank Sharad Kale
Keyword(s):  
Radiation Dose ◽  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Uveal Melanoma ◽  
Planning System ◽  
Treatment Planning System ◽  
Eye Lens ◽  
Organ Doses ◽  
Stereotactic Frame ◽  
Gamma Knife Stereotactic Radiosurgery

AbstractThe purpose of the study was to analyze single fraction Gamma Knife stereotactic radiosurgery (SRS) for uveal melanoma (UM). In the treatment of UMs, the dose distribution exhibited by an irregular eye surface has more calculation uncertainty. A tissue-equivalent bolus was placed on the left eye surface of a human head-shaped phantom. It was assumed that the treated eye is fixed using retrobulbar anesthesia and suture on extraocular muscles for phantom study. Leksell stereotactic frame was fixed around phantom’s head and the stereotactic computed tomography (CT) was performed. Two sets of scans were acquired (a) without bolus and (b) with a bolus of 1.0 cm thickness. These scans were transferred into a treatment planning system (TPS). The skull contouring was performed using stereotactic CT images. The target, visual pathways, and eye lens were delineated in stereotactic CT space created on TPS. A clinical relevant plan was designed on the CT study set “a” to deliver a radiation dose of 30Gy at tumor margin. The plan superimposed over CT study set “b” and compiled for convincing treatment strategy. The tumor coverage was 95% at 50% prescription isodose line. The conformity index, selectivity and the gradient index were 1.27, 0.80 and 3.28 respectively. The left optic nerve and eye lens received a maximum dose of 11.1 Gy and 11.0 Gy respectively. The treatment plan overlay showed similar planning indices and critical organ doses. The plan comparison showed: an irradiated volume received the radiation dose > 15 Gy varies < 1.0% whereas the volume received < 15 Gy were larger (> 1.0%) in the study set “b”. The distant lateral points from the target volume which describe the phantom’s eyelid showed a radiation dose of 3.2 Gy - 2.5 Gy. The doses to these points were misled and ignored in the CT study set “a”. The eye bolus provides better dosimetric information in the estimation of low dose areas which is commonly misled on TPS in SRS planning for UMs.

Skull base aneurysmal bone cyst presenting with hydrocephalus: progressive residuum obliterated by Gamma Knife stereotactic radiosurgery in a pediatric patient

2020 ◽  
Vol 26 (1) ◽  
pp. 76-81
Author(s):  
George H. Tse ◽  
Feng Y. Jiang ◽  
Matthias W. R. Radatz ◽  
Saurabh Sinha ◽  
Hesham Zaki
Keyword(s):  
Skull Base ◽  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Pediatric Population ◽  
Bone Cyst ◽  
Disease Free Survival ◽  
Long Term Follow Up ◽  
Aneurysmal Bone Cysts ◽  
Gamma Knife Stereotactic Radiosurgery

Aneurysmal bone cysts (ABCs) are an uncommon entity predominantly encountered in the pediatric population. The skull is rarely involved, but these cysts have been reported to arise in the skull base. Traditional treatment has been with surgery alone; however, there is a gathering body of literature that reports alternative treatments that can achieve long-term disease-free survival. However, these therapies are predominantly directed at peripheral skeletal lesions. To the authors’ knowledge, this report is the first to describe long-term follow-up of the efficacy of Gamma Knife stereotactic radiosurgery for treatment of ABC residuum in the skull base that resulted in long-term patient stability and likely ABC obliteration.

scholarly journals Brainstem metastases treated with Gamma Knife stereotactic radiosurgery: the Indiana University Health experience

CNS Oncology ◽  
2018 ◽  
Vol 7 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Ajay Patel ◽  
Homan Mohammadi ◽  
Tuo Dong ◽  
Kevin Ren-Yeh Shiue ◽  
Douglas Frye ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Indiana University ◽  
Gamma Knife Stereotactic Radiosurgery

Gamma knife stereotactic radiosurgery for drug resistant or intolerant invasive prolactinomas

Pituitary ◽  
2012 ◽  
Vol 16 (1) ◽  
pp. 68-75 ◽  
Author(s):  
Xiaomin Liu ◽  
Hideyuki Kano ◽  
Douglas Kondziolka ◽  
Kyung-Jae Park ◽  
Aditya Iyer ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Drug Resistant ◽  
Gamma Knife Stereotactic Radiosurgery

scholarly journals Intracranial Metastatic Neuroblastoma Treated with Gamma Knife Stereotactic Radiosurgery: Report of Two Novel Cases

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Nathan C. Rowland ◽  
Jennifer Andrews ◽  
Daxa Patel ◽  
David V. LaBorde ◽  
Adam Nowlan ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Treatment Options ◽  
Tumor Burden ◽  
Poor Survival ◽  
Intracranial Metastasis ◽  
Temporary Reduction ◽  
Single Fraction ◽  
Curative Therapy ◽  
Gamma Knife Stereotactic Radiosurgery

Intracranial metastasis of neuroblastoma (IMN) is associated with poor survival. No curative therapy for the treatment of IMN currently exists. Unfractionated radiotherapy may be beneficial in the treatment of IMN given the known radiosensitivity of neuroblastoma as well as its proclivity to metastasize as discrete lesions. We present two patients with IMN treated with Gamma Knife stereotactic radiosurgery (SRS). Single-fraction radiotherapy yielded temporary reduction of tumor burden and stability of disease in both patients. SRS may be a useful palliative tool in the treatment of IMN and expands the overall treatment options for this disease.

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